NSG 830 Exam 1 Mod 1 Pharm Exam 1 study guide
Questions With Complete Solutions
Absorption Correct Answers the drug's movement from its site
of administration into the blood.
Bioavailability Correct Answers the amount of active drug that
reaches the systemic circulation from its site of administration
Biomarkers Correct Answers a measurable substance in an
organism whose presence is indicative of some phenomenon
such as disease, infection, or environmental exposure.
Boxed Warning Correct Answers Drug warning that is placed in
the prescribing information or package insert of the product and
indicates a significant risk of potentially dangerous side effects.
It is the strongest safety warning that a drug can carry and still
remain on the market
channels and pores Correct Answers only very small ions such
as potassium and sodium can pass through
Distribution Correct Answers the drug's movement from the
blood to the interstitial space of tissues and from there into cells.
Elimination Correct Answers combination of metabolism and
excretion
Examples of organ specific toxicity Correct Answers
Amphotericin B (an antifungal drug) can cause kidney injury.
Doxorubicin can cause injury to the heart.
, Amiodarone can cause injury to the lungs
Excretion Correct Answers the movement of the drugs and their
metabolites out of the body (via the urine, feces, sweat, milk,
etc)
Factors that affect drug absorption Correct Answers rate of
dissolution, surface area, blood flow, lipid solubility, pH
partitioning
Four pathologic conditions that modify drug responses Correct
Answers Kidney disease, liver disease, acid-base balance, and
altered electrolyte status
How do drugs cross the placenta? Correct Answers Simple
diffusion (aka passive transfer)
How do prostaglandins affect pregnancy? Correct Answers
Prostaglandins (i.e misoprostol) stimulate uterine contraction,
which can cause abortion.
How does Acid-base balance modify drug responses? Correct
Answers Because of pH partitioning, if there is a difference in
pH on two sides of a membrane, a drug will accumulate on the
side where the pH most favors its ionization.
How does altered electrolyte status modify drug responses?
Correct Answers Ex. When potassium levels are low
(hypokalemia), the ability of digoxin to induce dysrhythmias is
greatly increased.
Questions With Complete Solutions
Absorption Correct Answers the drug's movement from its site
of administration into the blood.
Bioavailability Correct Answers the amount of active drug that
reaches the systemic circulation from its site of administration
Biomarkers Correct Answers a measurable substance in an
organism whose presence is indicative of some phenomenon
such as disease, infection, or environmental exposure.
Boxed Warning Correct Answers Drug warning that is placed in
the prescribing information or package insert of the product and
indicates a significant risk of potentially dangerous side effects.
It is the strongest safety warning that a drug can carry and still
remain on the market
channels and pores Correct Answers only very small ions such
as potassium and sodium can pass through
Distribution Correct Answers the drug's movement from the
blood to the interstitial space of tissues and from there into cells.
Elimination Correct Answers combination of metabolism and
excretion
Examples of organ specific toxicity Correct Answers
Amphotericin B (an antifungal drug) can cause kidney injury.
Doxorubicin can cause injury to the heart.
, Amiodarone can cause injury to the lungs
Excretion Correct Answers the movement of the drugs and their
metabolites out of the body (via the urine, feces, sweat, milk,
etc)
Factors that affect drug absorption Correct Answers rate of
dissolution, surface area, blood flow, lipid solubility, pH
partitioning
Four pathologic conditions that modify drug responses Correct
Answers Kidney disease, liver disease, acid-base balance, and
altered electrolyte status
How do drugs cross the placenta? Correct Answers Simple
diffusion (aka passive transfer)
How do prostaglandins affect pregnancy? Correct Answers
Prostaglandins (i.e misoprostol) stimulate uterine contraction,
which can cause abortion.
How does Acid-base balance modify drug responses? Correct
Answers Because of pH partitioning, if there is a difference in
pH on two sides of a membrane, a drug will accumulate on the
side where the pH most favors its ionization.
How does altered electrolyte status modify drug responses?
Correct Answers Ex. When potassium levels are low
(hypokalemia), the ability of digoxin to induce dysrhythmias is
greatly increased.
