NUR 635 Advanced Pharmacology Midterm Exam
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Terms in this set (334)
the study of drugs and their structure, targets of
action, mechanisms of action (MOA), distribution (how
Pharmacology the body disburses them throughout the body),
desired physiologic effects (efficacy) and undesirable
side effects (toxicity).
Pharmacokinetics includes ADME (absorption, distribution, metabolism and
the following: elimination).
Pharmacokinetics is... How the body effects the drug
absorption from the administration site either directly
Absorption
or indirectly into the blood/plasma.
reversibly/irreversibly movement of drug from the
Distribution
bloodstream into the interstitial and intracellular fluid.
drug biotransformation via metabolic pathways,
Metabolism
primarily the liver, or by other tissues.
how parent drug & its metabolites are eliminated from
Elimination
the body
, · Gastrointestinal pH changes
· Gastric emptying
· Gastric/intestinal enzymes
· Bile acids & biliary function
Absorption factors
· Gastrointestinal flora (type and quantity of bacteria)
· Food & nutrient interactions (most common
interaction influencing GI drug absorption)
· Lipid solubility of the drug
· Membrane permeability: Cross membranes to site of
action
· Blood brain barrier reduces the speed of drug
passage into and out of brain tissue
· Plasma protein binding: drugs bound to plasma
proteins do not cross membranes (Note: Malnutrition
Distribution factors = âalbumin = á free drug = greater pharmacologic
response)
· Aging cause a reduction in production of plasma
proteins
· Lipophilicity of drug: lipophilic drugs concentrate in
adipose tissue; remain in the body for a longer period
of time
· Body Composition
- Increased Total body water and extracellular fluid
-Decreased Adipose tissue and skeletal muscle
· Protein Binding (changes with aging)
-Albumin, bilirubin, a1-acid glycoprotein
Volume of distribution
-Albumin affected by nutrition
-Low albumin (hypoalbuminemia) can cause less
protein-bound drug reaching the tissue site of action.
· Tissue Binding
- Compositional changes
COMPREHENSIVE questions answered, 2025
verified graded A+ already passed!
Save
Terms in this set (334)
the study of drugs and their structure, targets of
action, mechanisms of action (MOA), distribution (how
Pharmacology the body disburses them throughout the body),
desired physiologic effects (efficacy) and undesirable
side effects (toxicity).
Pharmacokinetics includes ADME (absorption, distribution, metabolism and
the following: elimination).
Pharmacokinetics is... How the body effects the drug
absorption from the administration site either directly
Absorption
or indirectly into the blood/plasma.
reversibly/irreversibly movement of drug from the
Distribution
bloodstream into the interstitial and intracellular fluid.
drug biotransformation via metabolic pathways,
Metabolism
primarily the liver, or by other tissues.
how parent drug & its metabolites are eliminated from
Elimination
the body
, · Gastrointestinal pH changes
· Gastric emptying
· Gastric/intestinal enzymes
· Bile acids & biliary function
Absorption factors
· Gastrointestinal flora (type and quantity of bacteria)
· Food & nutrient interactions (most common
interaction influencing GI drug absorption)
· Lipid solubility of the drug
· Membrane permeability: Cross membranes to site of
action
· Blood brain barrier reduces the speed of drug
passage into and out of brain tissue
· Plasma protein binding: drugs bound to plasma
proteins do not cross membranes (Note: Malnutrition
Distribution factors = âalbumin = á free drug = greater pharmacologic
response)
· Aging cause a reduction in production of plasma
proteins
· Lipophilicity of drug: lipophilic drugs concentrate in
adipose tissue; remain in the body for a longer period
of time
· Body Composition
- Increased Total body water and extracellular fluid
-Decreased Adipose tissue and skeletal muscle
· Protein Binding (changes with aging)
-Albumin, bilirubin, a1-acid glycoprotein
Volume of distribution
-Albumin affected by nutrition
-Low albumin (hypoalbuminemia) can cause less
protein-bound drug reaching the tissue site of action.
· Tissue Binding
- Compositional changes
