Test Bank For Pathophysiology 9th Edition mccance The Biologic Basis for
Disease in Adults and Children By Julia Rogers
TEST BANK
,Chapter 01: Cellular Biology
Mccance/Huether: Pathophysiology: The Biologic Basis of Disease in Adults and Children, 9th Edition
MULTIPLE CHOICE
1. Which statement best describes the cellular function of metabolic absorption?
a. Cells can produce proteins.
b. Cells can secrete digestive enzymes.
c. Cells can take in and use nutrients.
d. Cells can synthesize fats.
ANS: C
In metabolic absorption, all cells take in and use nutrients and other substances from their
surroundings. The remaining options are not inclusive in their descriptions of cellular metabolic
absorption.
PTS: 1
J DIF: Cognitive Level: Remembering
2. Where is most of a cell’s genetic information, including RNA and DNA, contained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: C
The nucleus contains the nucleolus, a small dense structure composed largely of RNA, most of the
cellular DNA, and the DNA-binding proteins, such as the histones, which regulate its activity. The
mitochondria are responsible for cellular respiration and energy production.
Ribosomes’ chief function is to provide sites for cellular protein synthesis. Lysosomes
function as the intracellular digestive system.
PTS: 1
J DIF: Cognitive Level: Remembering
3. Which component of the cell produces hydrogen peroxide (H2O2) by using oxygen to remove
hydrogen atoms from specific substrates in an oxidative reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: B
Peroxisomes are so named because they usually contain enzymes that use oxygen to remove
hydrogen atoms from specific substrates in an oxidative reaction that produces H2O2, which is a
powerful oxidant and potentially destructive if it accumulates or escapes from peroxisomes.
Ribosomes are RNA-protein complexes (nucleoproteins) that are synthesized in the nucleolus and
secreted into the cytoplasm through pores in the nuclear envelope called nuclear pore complexes.
Lysosomes are saclike structures that originate from the Golgi complex and contain more than 40
digestive enzymes called hydrolases, which catalyze bonds in proteins, lipids, nucleic acids, and
carbohydrates. An endosome is a vesical that has been pinched off from the cellular membrane.
PTS: 1
J DIF: Cognitive Level: Remembering
4. Which cell component is capable of cellular autodigestion when it is released during cell injury?
, a. Ribosome
b. Golgi complex
c. Smooth endoplasmic reticulum
d. Lysosomes
ANS: D
The lysosomal membrane acts as a protective shield between the powerful digestive enzymes within
the lysosome and the cytoplasm, preventing their leakage into the cytoplasmic matrix. Disruption of
the membrane by various treatments or cellular injury leads to a release of the lysosomal enzymes,
which can then react with their specific substrates, causing cellular
Self-digestion. The chief function of a ribosome is to provide sites for cellular protein synthesis. The
Golgi complex is a network of flattened, smooth vesicles and membranes often located near the cell
nucleus. The smooth endoplasmic reticulum is involved in steroid hormone production and removing
toxic substances from the cell.
PTS: 1J DIF: Cognitive Level: Remembering
5. Which camp-mediated response is related to antidiuretic hormone?
a. Increased heart rate and force of contraction
b. Secretion of cortisol
c. Increased retention of water
d. Breakdown of fat
ANS: C
Antidiuretic hormone leads to increased retention of water in the body. Epinephrine causes
increases in heart rate and force of contraction. Increased cortisol secretion is due to ACTH.
Breakdown of fat is due to glucagon.
PTS: 1J DIF: Cognitive Level: Remembering
6. During which phase of the cell cycle is DNA synthesized?
a. G1
b. S
c. G2
d. M
ANS: B
The four designated phases of the cell cycle are: (1) the G1 phase (G = gap), which is the period
between the M phase (M = mitosis) and the start of DNA synthesis; (2) the S phase (S
= synthesis), during which DNA is synthesized in the cell nucleus; (3) the G2 phase, during which
RNA and protein synthesis occurs, the period between the completion of DNA synthesis and the next
phase (M); and (4) the M phase, which includes nuclear and cytoplasmic division.
PTS: 1J DIF: Cognitive Level: Remembering
7. What organic compound facilitates transportation across cell membranes by acting as
receptors, transport channels for electrolytes, and enzymes to drive active pumps?
a. Lipids
b. Proteases
c. Proteins
d. Carbohydrates
ANS: C
Proteins have several functions, including acting as receptors, transport channels for electrolytes, and
enzymes to drive active pumps Lipids help act as the ―glue‖ holding cell membranes together.
Proteases cause the breakdown of protein. Carbohydrates are involved in cellular protection and
lubrication and help produce energy via oxidative phosphorylation.
, PTS: 1
J DIF: Cognitive Level: Remembering
8. Understanding the various steps of proteolytic cascades may be useful in designing drug therapy
for which human diseases?
a. Cardiac and vascular disorders
b. Autoimmune and malignant disorders
c. Gastrointestinal and renal disorders
d. Endocrine and gastrointestinal disorders
ANS: B
Understanding the various steps involved in this process is crucial for designing drug interventions.
Dysregulation of proteases features prominently in many human diseases, including cancer,
autoimmunity, and neurodegenerative disorders. Cardiac, vascular, gastrointestinal, renal, and
endocrine disorders do not involve this process.
PTS: 1
J DIF: Cognitive Level: Remembering
9. Which structure prevents water-soluble molecules from entering cells across the plasma
membrane?
a. Carbohydrate chains
b. Glycoprotein channels
c. Membrane channel proteins
d. Lipid bilayer
ANS: D
The bilayer’s structure accounts for one of the essential functions of the plasma membrane. It is
impermeable to most water-soluble molecules (molecules that dissolve in water) because the water-
soluble molecules are insoluble in the oily core region. The bilayer serves as a barrier to the
diffusion of water and hydrophilic substances while allowing lipid-soluble molecules, such as
oxygen (O2) and carbon dioxide (CO2), to diffuse through it readily.
Carbohydrate chains, glycoprotein channels, and membrane channel proteins do not prevent water-
soluble molecules from entering cells across the cell membrane.
PTS: 1
J DIF: Cognitive Level: Remembering
10. A student asks for an explanation of the absolute refractory period of the action potential. What
response by the professor is best?
a. A stronger than normal impulse will evoke another response.
b. No stimulus is able to evoke another response at this time.
c. Multiple stimuli can produce more rapid action potentials.
d. The hyperpolarized state means a weaker stimulus produces a response.
ANS: B
During the absolute refractory state of the action potential, no stimulus is able to evoke another
response from the cell. A stronger than normal impulse may generate a response in the relative
refractory period. This period of time is not related to the number of stimuli. A hyperpolarized state
means a stronger than normal stimulus would be needed to generate a response.
PTS: 1
J DIF: Cognitive Level: Remembering
11. Which form of cell communication is used to communicate within the cell itself and with other
cells in direct physical contact?
a. Protein channel (gap junction)
b. Plasma membrane-bound signaling molecules
c. Hormone secretion such as neurotransmitters
d. Extracellular chemical messengers such as ligands
Disease in Adults and Children By Julia Rogers
TEST BANK
,Chapter 01: Cellular Biology
Mccance/Huether: Pathophysiology: The Biologic Basis of Disease in Adults and Children, 9th Edition
MULTIPLE CHOICE
1. Which statement best describes the cellular function of metabolic absorption?
a. Cells can produce proteins.
b. Cells can secrete digestive enzymes.
c. Cells can take in and use nutrients.
d. Cells can synthesize fats.
ANS: C
In metabolic absorption, all cells take in and use nutrients and other substances from their
surroundings. The remaining options are not inclusive in their descriptions of cellular metabolic
absorption.
PTS: 1
J DIF: Cognitive Level: Remembering
2. Where is most of a cell’s genetic information, including RNA and DNA, contained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: C
The nucleus contains the nucleolus, a small dense structure composed largely of RNA, most of the
cellular DNA, and the DNA-binding proteins, such as the histones, which regulate its activity. The
mitochondria are responsible for cellular respiration and energy production.
Ribosomes’ chief function is to provide sites for cellular protein synthesis. Lysosomes
function as the intracellular digestive system.
PTS: 1
J DIF: Cognitive Level: Remembering
3. Which component of the cell produces hydrogen peroxide (H2O2) by using oxygen to remove
hydrogen atoms from specific substrates in an oxidative reaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: B
Peroxisomes are so named because they usually contain enzymes that use oxygen to remove
hydrogen atoms from specific substrates in an oxidative reaction that produces H2O2, which is a
powerful oxidant and potentially destructive if it accumulates or escapes from peroxisomes.
Ribosomes are RNA-protein complexes (nucleoproteins) that are synthesized in the nucleolus and
secreted into the cytoplasm through pores in the nuclear envelope called nuclear pore complexes.
Lysosomes are saclike structures that originate from the Golgi complex and contain more than 40
digestive enzymes called hydrolases, which catalyze bonds in proteins, lipids, nucleic acids, and
carbohydrates. An endosome is a vesical that has been pinched off from the cellular membrane.
PTS: 1
J DIF: Cognitive Level: Remembering
4. Which cell component is capable of cellular autodigestion when it is released during cell injury?
, a. Ribosome
b. Golgi complex
c. Smooth endoplasmic reticulum
d. Lysosomes
ANS: D
The lysosomal membrane acts as a protective shield between the powerful digestive enzymes within
the lysosome and the cytoplasm, preventing their leakage into the cytoplasmic matrix. Disruption of
the membrane by various treatments or cellular injury leads to a release of the lysosomal enzymes,
which can then react with their specific substrates, causing cellular
Self-digestion. The chief function of a ribosome is to provide sites for cellular protein synthesis. The
Golgi complex is a network of flattened, smooth vesicles and membranes often located near the cell
nucleus. The smooth endoplasmic reticulum is involved in steroid hormone production and removing
toxic substances from the cell.
PTS: 1J DIF: Cognitive Level: Remembering
5. Which camp-mediated response is related to antidiuretic hormone?
a. Increased heart rate and force of contraction
b. Secretion of cortisol
c. Increased retention of water
d. Breakdown of fat
ANS: C
Antidiuretic hormone leads to increased retention of water in the body. Epinephrine causes
increases in heart rate and force of contraction. Increased cortisol secretion is due to ACTH.
Breakdown of fat is due to glucagon.
PTS: 1J DIF: Cognitive Level: Remembering
6. During which phase of the cell cycle is DNA synthesized?
a. G1
b. S
c. G2
d. M
ANS: B
The four designated phases of the cell cycle are: (1) the G1 phase (G = gap), which is the period
between the M phase (M = mitosis) and the start of DNA synthesis; (2) the S phase (S
= synthesis), during which DNA is synthesized in the cell nucleus; (3) the G2 phase, during which
RNA and protein synthesis occurs, the period between the completion of DNA synthesis and the next
phase (M); and (4) the M phase, which includes nuclear and cytoplasmic division.
PTS: 1J DIF: Cognitive Level: Remembering
7. What organic compound facilitates transportation across cell membranes by acting as
receptors, transport channels for electrolytes, and enzymes to drive active pumps?
a. Lipids
b. Proteases
c. Proteins
d. Carbohydrates
ANS: C
Proteins have several functions, including acting as receptors, transport channels for electrolytes, and
enzymes to drive active pumps Lipids help act as the ―glue‖ holding cell membranes together.
Proteases cause the breakdown of protein. Carbohydrates are involved in cellular protection and
lubrication and help produce energy via oxidative phosphorylation.
, PTS: 1
J DIF: Cognitive Level: Remembering
8. Understanding the various steps of proteolytic cascades may be useful in designing drug therapy
for which human diseases?
a. Cardiac and vascular disorders
b. Autoimmune and malignant disorders
c. Gastrointestinal and renal disorders
d. Endocrine and gastrointestinal disorders
ANS: B
Understanding the various steps involved in this process is crucial for designing drug interventions.
Dysregulation of proteases features prominently in many human diseases, including cancer,
autoimmunity, and neurodegenerative disorders. Cardiac, vascular, gastrointestinal, renal, and
endocrine disorders do not involve this process.
PTS: 1
J DIF: Cognitive Level: Remembering
9. Which structure prevents water-soluble molecules from entering cells across the plasma
membrane?
a. Carbohydrate chains
b. Glycoprotein channels
c. Membrane channel proteins
d. Lipid bilayer
ANS: D
The bilayer’s structure accounts for one of the essential functions of the plasma membrane. It is
impermeable to most water-soluble molecules (molecules that dissolve in water) because the water-
soluble molecules are insoluble in the oily core region. The bilayer serves as a barrier to the
diffusion of water and hydrophilic substances while allowing lipid-soluble molecules, such as
oxygen (O2) and carbon dioxide (CO2), to diffuse through it readily.
Carbohydrate chains, glycoprotein channels, and membrane channel proteins do not prevent water-
soluble molecules from entering cells across the cell membrane.
PTS: 1
J DIF: Cognitive Level: Remembering
10. A student asks for an explanation of the absolute refractory period of the action potential. What
response by the professor is best?
a. A stronger than normal impulse will evoke another response.
b. No stimulus is able to evoke another response at this time.
c. Multiple stimuli can produce more rapid action potentials.
d. The hyperpolarized state means a weaker stimulus produces a response.
ANS: B
During the absolute refractory state of the action potential, no stimulus is able to evoke another
response from the cell. A stronger than normal impulse may generate a response in the relative
refractory period. This period of time is not related to the number of stimuli. A hyperpolarized state
means a stronger than normal stimulus would be needed to generate a response.
PTS: 1
J DIF: Cognitive Level: Remembering
11. Which form of cell communication is used to communicate within the cell itself and with other
cells in direct physical contact?
a. Protein channel (gap junction)
b. Plasma membrane-bound signaling molecules
c. Hormone secretion such as neurotransmitters
d. Extracellular chemical messengers such as ligands
