Patient population
Index test/test of interest
PIRT
Reference test that represents standard of care
Target condition
What are the acronyms used to help PICO/PIRT
formulate a well defined searchable
question?
Test results that indicate disease is present True positive
and patient has the disease?
Test results that indicate disease is present False positive
and patient does not have the disease?
Test results that indicate disease is not True negative
present and patient does not have disease?
Test results that indicate disease is not False negative
present but patient does actually have the
disease?
What is known as the chance that the test Sensitivity
will detect what it is intended to detect?
What is the formula for sensitivity? SN = TP/(TP+FN)
What is known as the chance that a test will Specificity
rule out a condition it should not detect?
What is the formula for specificity? SP = TN/(TN+FP)
If __ is high, a negative test will rule a Sensitivity (SnOUT)
disorder OUT.
, If __ is high, a positive will rule the disorder Specificity (SpIN)
IN.
A sensitive test minimizes the____. False negatives
A specific test minimizes the__ _. False positives
What answers the question "How likely is it Positive predictive value
that his patient has the disease given that
the test result is positive?"
PPV = True positive/ (True positive + false positive)
What answers the question "How likely is it Negative predictive value
that this patient does not have the disease
given that the test result is negative?"
NPV = True negatives/ (True negative + false negative)
What answers the question "How much Likelihood ratio
more likely is it that a patient who tests
positive has the disease compared with
one who tests negative"?
LR = Sensitivity/ (1-specificity)
What does a LR greater than 1 mean? Increases probability that target disorder present
What does a LR less than 1 mean? Decreases probability that target disorder present
LR of 1 means __ in the likelihood of No change
disease.
LR > 10 means __ in the likelihood of Large and often conclusive increase
disease.
LR < 0.1 means __ in the likelihood of Large and often conclusive decrease
disease.
LR 5-10 means _ in the likelihood of Moderate increase
disease.
LR of 0.1-0.2 means __ in the likelihood of Moderate decrease
disease.
LR of 2-5 means __ in the likelihood of Small increase
disease.
LR of 0.2-0.5 means__ in the likelihood of Small decrease
disease.
LR of 1-2 means __in the likelihood of Minimal increase
disease.
LR of 0.5-1 means__ in the likelihood of Minimal decrease
disease.
+ Upper limb tension test
What is the cluster used for ruling IN + Spurling test
cervical radiculopathy? + Distraction test
Cervical rotation less than 60 degrees to insulate real side
If 4 of the cluster test for cervical Specificity
radiculopathy are positive, would this
represent a high sensitivity or specificity?