PHA 317: Pharmaceutics Quiz 10 – 11 UPDATED ACTUAL Questions and
CORRECT Answers
The rate of general acid- and base- True
catalysis is affected by concentration of
undissociated buffer components in
addition to hydronium and hydroxyl ion
concentration
The initial concentration of active principle 20.5 months
in an aqueous preparation was 5.0 X 10^-3
g/mL. After 10 months the concentration
was found to be 4.2 X 10^-3 g/mL. The drug
is known to be ineffective after it has
decomposed to 70% of its original
concentration. Assuming that
decomposition follows first order kinetics,
calculate the expiry date of the drug
preparation.
Dissolution rate can be increased by: Increasing the diffusion coefficient
The rate of dissolution when surface area Intrinsic dissolution rate
exposed to the solvent/medium remains
the same is called:
Hydrogen peroxide is stored in dark photolysis
container to prevent it from
Following are some approaches to prevent All i-iv are correct
the oxidative degradation of drug:
i. Using an initiation inhibitor such as EDTA
(ethylene diamine tetraacatic acid)
ii. Using colored glass containers
iii. Using chain breakers such as alpha
tocopherol
iv. Using oxygen scavengers such as
sodium metabisulfite and ascorbic acid
, The release of a drug from a matrix system Both i and ii are correct
occurs by:
i. diffusion from the matrix system
ii. erosion of the matrix system
Initial burst release is observed for which of Hydrophilic or swellable matrix systems
the following matrix-based controlled drug
release system:
Which is not a variable in the Noyes and pH
Whitney equation?
Generally, surface area does not remain True
constant throughout the dissolution
Ampicillin degrades much faster in water Only i is correct
than in alcohol because
i. water, being a high dielectric constant
solvent, converts the neutral ampicillin into
a charged transition complex.
ii. water, being a low dielectric constant
solvent, converts the neutral ampicillin into
a charged transition complex.
Dissolution testing is conducted by Sink
manufacturers under what conditions?
Following are the steps involved in the Both i and ii are correct
process of determining shelf-life or
expiration date of a drug:
i. Reaction rate constant, k, is determined at
various elevated temperatures
ii. A plot of log k vs 1/T will be a straight line
which can provide the value of k at room
temperature
An increase in temperature by 10 degrees a 2-4 fold increase in reaction rate for many reactions
Celsius near room temperature is know to
cause:
Select the most appropriate term which supersaturation
completes this sentence: Sodium salicylate
is capable of ____ at the diffusion layer
and displays a greater rate of dissolution
under conditions of more acidic simulated
gastric fluid than salicyclic acid.
What will be the effect on flux if the Flux would be doubled
concentration gradient of a drug across a
membrane would increase two fold?
Insoluble polymers such as ethyl cellulose, True
methylmethacrylate, or polyvinyl acetate
are used for making inert matrix-based
extended drug release systems
Which of the following equations predicts The Arrhenius equation
the stability of a drug at room temperature
from experiments at accelerated condition
at higher temperatures?
CORRECT Answers
The rate of general acid- and base- True
catalysis is affected by concentration of
undissociated buffer components in
addition to hydronium and hydroxyl ion
concentration
The initial concentration of active principle 20.5 months
in an aqueous preparation was 5.0 X 10^-3
g/mL. After 10 months the concentration
was found to be 4.2 X 10^-3 g/mL. The drug
is known to be ineffective after it has
decomposed to 70% of its original
concentration. Assuming that
decomposition follows first order kinetics,
calculate the expiry date of the drug
preparation.
Dissolution rate can be increased by: Increasing the diffusion coefficient
The rate of dissolution when surface area Intrinsic dissolution rate
exposed to the solvent/medium remains
the same is called:
Hydrogen peroxide is stored in dark photolysis
container to prevent it from
Following are some approaches to prevent All i-iv are correct
the oxidative degradation of drug:
i. Using an initiation inhibitor such as EDTA
(ethylene diamine tetraacatic acid)
ii. Using colored glass containers
iii. Using chain breakers such as alpha
tocopherol
iv. Using oxygen scavengers such as
sodium metabisulfite and ascorbic acid
, The release of a drug from a matrix system Both i and ii are correct
occurs by:
i. diffusion from the matrix system
ii. erosion of the matrix system
Initial burst release is observed for which of Hydrophilic or swellable matrix systems
the following matrix-based controlled drug
release system:
Which is not a variable in the Noyes and pH
Whitney equation?
Generally, surface area does not remain True
constant throughout the dissolution
Ampicillin degrades much faster in water Only i is correct
than in alcohol because
i. water, being a high dielectric constant
solvent, converts the neutral ampicillin into
a charged transition complex.
ii. water, being a low dielectric constant
solvent, converts the neutral ampicillin into
a charged transition complex.
Dissolution testing is conducted by Sink
manufacturers under what conditions?
Following are the steps involved in the Both i and ii are correct
process of determining shelf-life or
expiration date of a drug:
i. Reaction rate constant, k, is determined at
various elevated temperatures
ii. A plot of log k vs 1/T will be a straight line
which can provide the value of k at room
temperature
An increase in temperature by 10 degrees a 2-4 fold increase in reaction rate for many reactions
Celsius near room temperature is know to
cause:
Select the most appropriate term which supersaturation
completes this sentence: Sodium salicylate
is capable of ____ at the diffusion layer
and displays a greater rate of dissolution
under conditions of more acidic simulated
gastric fluid than salicyclic acid.
What will be the effect on flux if the Flux would be doubled
concentration gradient of a drug across a
membrane would increase two fold?
Insoluble polymers such as ethyl cellulose, True
methylmethacrylate, or polyvinyl acetate
are used for making inert matrix-based
extended drug release systems
Which of the following equations predicts The Arrhenius equation
the stability of a drug at room temperature
from experiments at accelerated condition
at higher temperatures?
