convert K to C -273.15
what 4 processes is equilibrium play an ionization of weak acids and bases, partition coefficient and lipid solubility of a drug,
important role for pharmaceutics? saturation solubility, and diffusion and dissolution of a drug
Molar heat capacity The heat required to raise the temperature of one mole of a substance by 1°
convert F to C (5X (F-32))/9
, van der waals surface areas for polar atoms, oxygens, nitrogens, and attached
what is the polar surface area?
hydrogen atoms
log x/y = log x - log y
keesom forces dipole-dipole
logx^y = y log x
An Angstrom unit A is equal to 10 ^ -10m
What law states that the heat change Hess's Law
associated with any reaction is
independent of the number of steps in
which the reaction occurs
debye forces dipole-induced dipole
london forces induced dipole-induced dipole
What is the specific gravity of a substance 0.01
of density 10Kg/m3? Given that the density
of water is 1g/cc.
ionic
electrostatic forces (3) ion dipole
dipole-dipole
does the hydrophilicity of a drug have to no
do with rate and extent of absorption of
drugs?
Density of a substance having volume 20 1.5
cm3 and mass 0.03kg= ____ gm/cc
Applications of free energy functions are calculations of eq. constant and derivation of the vant hoff equation
log y√ x = (1/y) log x
enatiotropic two different polymorphs stable at 2 different temperature ranges
The third law of thermodynamics deals Entropy at absolute zero
with?
monotropic only one polymorph is stable at all temps below mp (others aren't stable
Vant hoff equation relates? The equilibrium constant of a reaction to the reaction temperature
amorphous solids random order, tend to flow, have a range of mp
are ionized or unionized drugs better for both can be depending on what the therapeutic effect is
therapeutic effect?
similar properties in all direction
isotropic solids
-amorphous
different properties in different directions
anisotropic solids
-crystalline solids
what happens when PSA is more than 140 absorption is less than 10%
A?
multicomponent system both amorphous and crystalline
1 erg is equal to ? 1 dyne x 1 cm
what happens when PSA is less than 60A absorption is more than 90%
The entropy of a pure crystalline substance Third law of thermodynamics
is zero at absolute zero according to?