PHA 317 Quiz 10 & 11 UPDATED ACTUAL
Questions and CORRECT Answers
Time taken for 5% of a drug to decompose by first-order kinetics is: - CORRECT
ANSWER - 0.05/k1
The following data were obtained for the hydrolysis of homatropin (which follows first order
kinetics) in 0.226 mol/L HCl at 90 degrees C - CORRECT ANSWER - 13.2 hr
For a single step (elementary) reaction, the molecularity and order are the same - CORRECT
ANSWER - True
The plasma level of an orally administered tablet depends on:
i. The rate of tablet disintegration
ii. The rate of dissolution of the drug - CORRECT ANSWER - Both i and ii are correct
The hydraulic degradation of acetylsalicylic acid in its aqueous suspension follows which kind of
kinetic? - CORRECT ANSWER - Pseudo zero-order
In a zero order reaction:
i. The rate of decomposition is dependent on the concentration of one of the reactants
ii. The rate of decomposition is independent on the concentration of any of the reactants
iii. A plot of the amount remaining (as ordinate) against time (abscissa) is linear with a slope of
1/k - CORRECT ANSWER - Only ii is correct
Prout-Tompkins Model best describes - CORRECT ANSWER - A solid state reaction
A base catalyzed hydrolysis of an ester such as chloramphenicol palmitate can exhibit:
i. a second-order kinetics only if the concentration of both -ester and base are changing
, ii. a pseudo first-order kinetics if the concentration of the hydroxyl ion is maintained constant
iii. a pseudo first-order kinetics if the concentration of both ester and base are maintained
constant
iv. a first-order kinetics if the concentration of the hydroxyl ion is maintained constant
v. zero-order kinetics if the concentration of both ester and base are maintained constant -
CORRECT ANSWER - Only I, ii, and iii are correct
Which of the following is not a characteristic of solid state reaction? - CORRECT
ANSWER - It happens in a homogenous medium
It is not conceivable for a reaction to have zero or fractional molecularity - CORRECT
ANSWER - True
In a second order reaction:
i. The rate of reaction depends on the concentration of two reacting species
ii. A plot of time (as abscissa) against (a0-a)/(aa0) (as ordinate) is linear with a slope equal to
1/k2
iii. The half-life is independent of the concentration
iv. The unit of k is concentration/time - CORRECT ANSWER - Only i and ii are correct
Lineweaver-Burke equation for an enzymatic reaction is useful for:
i. Determining the constant Km in Michaelis Menton equation
ii. Determining the constant Vmax in Michaelis Menton equation
iii. Determining only the constant Km or Vmax but not simultaneously in Michaelis Menton
equation - CORRECT ANSWER - Both i and ii are correct
In a study of the hydrolysis of a drug in an aqueous solution a plot of logarithm of the amount of
drug remaining (as ordinate) against time (abscissa) is linear:
i. The reaction is zero order
ii. The slope is -2.303/k
Questions and CORRECT Answers
Time taken for 5% of a drug to decompose by first-order kinetics is: - CORRECT
ANSWER - 0.05/k1
The following data were obtained for the hydrolysis of homatropin (which follows first order
kinetics) in 0.226 mol/L HCl at 90 degrees C - CORRECT ANSWER - 13.2 hr
For a single step (elementary) reaction, the molecularity and order are the same - CORRECT
ANSWER - True
The plasma level of an orally administered tablet depends on:
i. The rate of tablet disintegration
ii. The rate of dissolution of the drug - CORRECT ANSWER - Both i and ii are correct
The hydraulic degradation of acetylsalicylic acid in its aqueous suspension follows which kind of
kinetic? - CORRECT ANSWER - Pseudo zero-order
In a zero order reaction:
i. The rate of decomposition is dependent on the concentration of one of the reactants
ii. The rate of decomposition is independent on the concentration of any of the reactants
iii. A plot of the amount remaining (as ordinate) against time (abscissa) is linear with a slope of
1/k - CORRECT ANSWER - Only ii is correct
Prout-Tompkins Model best describes - CORRECT ANSWER - A solid state reaction
A base catalyzed hydrolysis of an ester such as chloramphenicol palmitate can exhibit:
i. a second-order kinetics only if the concentration of both -ester and base are changing
, ii. a pseudo first-order kinetics if the concentration of the hydroxyl ion is maintained constant
iii. a pseudo first-order kinetics if the concentration of both ester and base are maintained
constant
iv. a first-order kinetics if the concentration of the hydroxyl ion is maintained constant
v. zero-order kinetics if the concentration of both ester and base are maintained constant -
CORRECT ANSWER - Only I, ii, and iii are correct
Which of the following is not a characteristic of solid state reaction? - CORRECT
ANSWER - It happens in a homogenous medium
It is not conceivable for a reaction to have zero or fractional molecularity - CORRECT
ANSWER - True
In a second order reaction:
i. The rate of reaction depends on the concentration of two reacting species
ii. A plot of time (as abscissa) against (a0-a)/(aa0) (as ordinate) is linear with a slope equal to
1/k2
iii. The half-life is independent of the concentration
iv. The unit of k is concentration/time - CORRECT ANSWER - Only i and ii are correct
Lineweaver-Burke equation for an enzymatic reaction is useful for:
i. Determining the constant Km in Michaelis Menton equation
ii. Determining the constant Vmax in Michaelis Menton equation
iii. Determining only the constant Km or Vmax but not simultaneously in Michaelis Menton
equation - CORRECT ANSWER - Both i and ii are correct
In a study of the hydrolysis of a drug in an aqueous solution a plot of logarithm of the amount of
drug remaining (as ordinate) against time (abscissa) is linear:
i. The reaction is zero order
ii. The slope is -2.303/k
