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Advanced Pharmacology Fundamentals
1. The process by which a drug moves from the site of administration into the bloodstream is
called:
• A. Distribution
• B. Absorption
• C. Metabolism
• D. Excretion
Answer: B
2. Which organ is the primary site of drug metabolism?
• A. Kidneys
• B. Liver
• C. Lungs
• D. Intestines
Answer: B
3. The term *first-pass effect* refers to:
• A. Initial renal clearance of a drug
• B. Drug metabolism in the liver before reaching systemic circulation
• C. Distribution of drug to fatty tissues
• D. The first dose response of a drug
Answer: B
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4. A drug with high lipid solubility is expected to:
• A. Cross cell membranes easily
• B. Be poorly absorbed
• C. Be rapidly excreted unchanged
• D. Have low bioavailability
Answer: A
5. The time taken for plasma concentration of a drug to reduce by 50% is known as:
• A. Clearance
• B. Bioavailability
• C. Half-life
• D. Steady state
Answer: C
6. The maximum effect a drug can produce is called:
• A. Potency
• B. Efficacy
• C. Affinity
• D. Selectivity
Answer: B