, Chapter1:PrinciplesofPharmacology q q q q
Multiple Choice q
1. refer(s) to specific molecular changes that occur when a drug binds to a
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particular target site or receptor, while
q q aretheresultingwidespread alterations
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in function.
q q
a. Drug action; therapeutic effects
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b. Side effects; drug effects
q q q
c. Therapeutic effects; side effects q q q
d. Drug action; drug effects
q q q
Answer: d q
Textbook Reference: Pharmacology: The Science of Drug Action
q q q q q q q
2. After drug administration has occurred, the amount ofdrug inthe blood that is free to bind
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at specific target sites is referred to as
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a. the therapeutic dose.
q q
b. first-pass effects. q
c. bioavailability.
d. ED50.
Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
3. The specific molecular changes that occur when a drug binds to a particular target site or
q q q q q q q q q q q q q q q
receptor are referred to as
q q q q q
a. drug effects.q
b. drug action. q
c. side effects.
q
d. placebo effects. q
Answer: b q
Textbook Reference: Pharmacology: The Science ofDrug Action
q q q q q q q
4. Which ofthe following is not a possible explanation for placebo effects?
q q q q q q q q q q q
a. Pavlovian conditioning q
b. Genetic variation q
c. Drug competition q
d. Expectation of outcome q q
Answer: c q
Textbook Reference: Pharmacology: The Science ofDrug Action
q q q q q q q
Page 1 of 1
q q q
,5. The administration of oxytocin has been proposed as a treatment for autism. q q q q q q q q q q
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
6. Which factor does not affect the pharmacokinetics of a drug?
q q q q q q q q q
a. Route of administration
q q
b. Lipid solubility
q
c. Depot binding q
d. Drug actionq
Answer: d q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
7. First-pass metabolism occurs when drugs are taken q q q q q q
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
8. The area postrema is one area in the brain where the
q q is not complete. q q q q q q q q q q
a. cerebrospinal fluid q
b. blood–brain barrier q
c. choroid plexus q
d. phospholipid membrane q
Answer: b q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
9. First-pass metabolism occurs with orally administered drugs because
q q q q q q q
a. their absorption is slowed by food.
q q q q q
b. drugs absorbed into the bloodstream from the stomach go to the liver on the wayto
q q q q q q q q q q q q q q q
general circulation.
q q
c. drugs must first survive the acidic environment of the stomach.
q q q q q q q q q
d. salivaryenzymes in the mouth begin the process of metabolism.
q q q q q q q q q
Answer: b q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
10. Toxic substances in the blood trigger a vomiting response byactivating the
q q q q q q q q q q q
a. blood–brain barrier. q
b. choroid plexus. q
c. area postrema.
q
d. median eminence. q
Page 2 of 2
q q q
, Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
11. Drugs administered _ have the most rapid onset of action.
q q q q q q q q
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
12. Ionization of a drug depends on the of the solution and the
q q q q q q q q q q ofthe
q
drug.
q
a. pH; pKa
q
b. pKa; pH q
c. concentration; lipid solubility q q
d. pH; concentration
q
Answer: a q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
13. The absorption of a drug depends on all of the following except
q q q q q q q q q q q
a. lipid solubility.
q
b. ionization.
c. body temperature. q
d. the concentration of the drug.
q q q q
Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
14. Drugs that are should be avoided by women of childbearing age.
q q q q q q q q q
a. teratogenic
b. able to cross the placental barrier
q q q q q
c. psychoactive
d. highly lipid-soluble q
Answer: a q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
15. Agents that induce developmental abnormalities in a fetus are known as
q q q q q q q q q q
a. psychoactive drugs. q
b. illicit drugs. q
c. teratogens.
d. placental drugs. q
Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
16. Depot binding is said to occur when drugs
q q q q q q q
a. bind to their target sites.
q q q q
Page 3 of 3
q q q
Multiple Choice q
1. refer(s) to specific molecular changes that occur when a drug binds to a
q q q q q q q q q q q q
particular target site or receptor, while
q q aretheresultingwidespread alterations
q q q q q q q q
in function.
q q
a. Drug action; therapeutic effects
q q q
b. Side effects; drug effects
q q q
c. Therapeutic effects; side effects q q q
d. Drug action; drug effects
q q q
Answer: d q
Textbook Reference: Pharmacology: The Science of Drug Action
q q q q q q q
2. After drug administration has occurred, the amount ofdrug inthe blood that is free to bind
q q q q q q q q q q q q q q q q
at specific target sites is referred to as
q q q q q q q q
a. the therapeutic dose.
q q
b. first-pass effects. q
c. bioavailability.
d. ED50.
Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
3. The specific molecular changes that occur when a drug binds to a particular target site or
q q q q q q q q q q q q q q q
receptor are referred to as
q q q q q
a. drug effects.q
b. drug action. q
c. side effects.
q
d. placebo effects. q
Answer: b q
Textbook Reference: Pharmacology: The Science ofDrug Action
q q q q q q q
4. Which ofthe following is not a possible explanation for placebo effects?
q q q q q q q q q q q
a. Pavlovian conditioning q
b. Genetic variation q
c. Drug competition q
d. Expectation of outcome q q
Answer: c q
Textbook Reference: Pharmacology: The Science ofDrug Action
q q q q q q q
Page 1 of 1
q q q
,5. The administration of oxytocin has been proposed as a treatment for autism. q q q q q q q q q q
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
6. Which factor does not affect the pharmacokinetics of a drug?
q q q q q q q q q
a. Route of administration
q q
b. Lipid solubility
q
c. Depot binding q
d. Drug actionq
Answer: d q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
7. First-pass metabolism occurs when drugs are taken q q q q q q
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
8. The area postrema is one area in the brain where the
q q is not complete. q q q q q q q q q q
a. cerebrospinal fluid q
b. blood–brain barrier q
c. choroid plexus q
d. phospholipid membrane q
Answer: b q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
9. First-pass metabolism occurs with orally administered drugs because
q q q q q q q
a. their absorption is slowed by food.
q q q q q
b. drugs absorbed into the bloodstream from the stomach go to the liver on the wayto
q q q q q q q q q q q q q q q
general circulation.
q q
c. drugs must first survive the acidic environment of the stomach.
q q q q q q q q q
d. salivaryenzymes in the mouth begin the process of metabolism.
q q q q q q q q q
Answer: b q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
10. Toxic substances in the blood trigger a vomiting response byactivating the
q q q q q q q q q q q
a. blood–brain barrier. q
b. choroid plexus. q
c. area postrema.
q
d. median eminence. q
Page 2 of 2
q q q
, Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
11. Drugs administered _ have the most rapid onset of action.
q q q q q q q q
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
12. Ionization of a drug depends on the of the solution and the
q q q q q q q q q q ofthe
q
drug.
q
a. pH; pKa
q
b. pKa; pH q
c. concentration; lipid solubility q q
d. pH; concentration
q
Answer: a q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
13. The absorption of a drug depends on all of the following except
q q q q q q q q q q q
a. lipid solubility.
q
b. ionization.
c. body temperature. q
d. the concentration of the drug.
q q q q
Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
14. Drugs that are should be avoided by women of childbearing age.
q q q q q q q q q
a. teratogenic
b. able to cross the placental barrier
q q q q q
c. psychoactive
d. highly lipid-soluble q
Answer: a q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
15. Agents that induce developmental abnormalities in a fetus are known as
q q q q q q q q q q
a. psychoactive drugs. q
b. illicit drugs. q
c. teratogens.
d. placental drugs. q
Answer: c q
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
q q q q q q
16. Depot binding is said to occur when drugs
q q q q q q q
a. bind to their target sites.
q q q q
Page 3 of 3
q q q
