WOUND LATEST
CERTIFICATION
EXAM
Explain wound healing by primary intention and give an example? -
ANSWERS-In primary intention, wound edges are well approximated
and heals by epithealization and connective tissue deposition. surgical
incision secured w/staples, surtures, or adhesive tape
explain wound healing by secondary intention and give and example? -
ANSWERS-wound edges are not approximated and healing occurs by
granulation tissue formation, contraction of wound edges, and
epithelialization. chronic wounds such as PU and dehisced incisions
explain wound healing by tertiary intentions and give examples? -
ANSWERS-aka delayed primary intention. wound is kept open for
several days. superficial wound eges then are approximated, and center
of wound heals by granulation tissue formation. abdominla incision
complicated by significant infection (deep tissue is healing by graulation
and superficial layer of skin is sutured)
"red islets" represent what part of the skin layer? - ANSWERS-basement
membrance of the epidermis, which projects deep into the dermis to line
the epidermal appendages. Each islets serves as a source of new
epithelium
END OF
PAGE
1
, WOUND LATEST
CERTIFICATION
EXAM
why is migration in wound healing delayed when wound is covered w/ a
scab? - ANSWERS-in order to create a moist envinroment, epithelial
cells secrete enzymes knwon as MMP (metallproteinases) to lift the scab
what are the major components of partial-thickness repair include? -
ANSWERS-1. inflammatory response to injury
2. epithelial proliferation and migration (resurfacing)
3. differentiation of the epidermal layers to restore barrier fx of skin
what happens in wound healing, if wound involves dermal loss -
ANSWERS-granulation formation or connective tissue repair will
precede concurrently with reepithealization
when do you know complete healing has occured in epithelial
resurfacing or healing by regeneration? - ANSWERS-when skin
pigmenation matches the individual's normal skin tone
what must be restored in partial dermal loss in wound healing? -
ANSWERS-rete ridges/dermal papillae
END OF
PAGE
2
, WOUND LATEST
CERTIFICATION
EXAM
what are the key components of proliferative phase? - ANSWERS-
epithealization, neoangiogenesis, and matrix deposition/collagen
synthesis
what are the 4 major phases in full-thickness repair? - ANSWERS-1.
hemostasis (platelets degranulate and release growth factors)
2. inflammatory (leakage of neutrophils, macrophages )
3. proliferative/rebuilding (cont recruitment of growth factors,
granulation formation, contraction of wound edges, epithelial
resurfacing)
4. maturation/remodeling (collagen synthesis)
granulation tissue is often referred to as - ANSWERS-extracellular
matrix (ECM)
in full-thickness wounds, why is the new epidermis slightly thinner than
original epidermis? - ANSWERS-ret pegs that normall dip into dermis is
lacking
END OF
PAGE
3
, WOUND LATEST
CERTIFICATION
EXAM
In chronic wounds where wound is healing by secondary intention, why
is healing delayed? - ANSWERS-hemostasis is absent, presence of
excess of proinflammartory cells where wound bed is bioburdened,
prolonged proliferative phase where granulation and wound contraction
must take place before epithealization
what are the characteristics of a chronic wound? - ANSWERS-
prolonged inflammatory phase,
cellular senescene, deficiency of growth factor receptor sites, absence of
hemostasis phase which triggers fibrin production and growth factor
release, and high level of proteases
how does diabetes effect repair process? - ANSWERS-prolongs
inflammation, reduces collagen synthesis, decreases tensile strength,
impairs epithelial migration, compromises vasculature
how does advance age affect wound healing? - ANSWERS-dimished
proliferation of cells critical to repair, increased number of senescent
cells, diminished production of growth factors, hormonal changes,
multiple co-existing comorbidities
END OF
PAGE
4
CERTIFICATION
EXAM
Explain wound healing by primary intention and give an example? -
ANSWERS-In primary intention, wound edges are well approximated
and heals by epithealization and connective tissue deposition. surgical
incision secured w/staples, surtures, or adhesive tape
explain wound healing by secondary intention and give and example? -
ANSWERS-wound edges are not approximated and healing occurs by
granulation tissue formation, contraction of wound edges, and
epithelialization. chronic wounds such as PU and dehisced incisions
explain wound healing by tertiary intentions and give examples? -
ANSWERS-aka delayed primary intention. wound is kept open for
several days. superficial wound eges then are approximated, and center
of wound heals by granulation tissue formation. abdominla incision
complicated by significant infection (deep tissue is healing by graulation
and superficial layer of skin is sutured)
"red islets" represent what part of the skin layer? - ANSWERS-basement
membrance of the epidermis, which projects deep into the dermis to line
the epidermal appendages. Each islets serves as a source of new
epithelium
END OF
PAGE
1
, WOUND LATEST
CERTIFICATION
EXAM
why is migration in wound healing delayed when wound is covered w/ a
scab? - ANSWERS-in order to create a moist envinroment, epithelial
cells secrete enzymes knwon as MMP (metallproteinases) to lift the scab
what are the major components of partial-thickness repair include? -
ANSWERS-1. inflammatory response to injury
2. epithelial proliferation and migration (resurfacing)
3. differentiation of the epidermal layers to restore barrier fx of skin
what happens in wound healing, if wound involves dermal loss -
ANSWERS-granulation formation or connective tissue repair will
precede concurrently with reepithealization
when do you know complete healing has occured in epithelial
resurfacing or healing by regeneration? - ANSWERS-when skin
pigmenation matches the individual's normal skin tone
what must be restored in partial dermal loss in wound healing? -
ANSWERS-rete ridges/dermal papillae
END OF
PAGE
2
, WOUND LATEST
CERTIFICATION
EXAM
what are the key components of proliferative phase? - ANSWERS-
epithealization, neoangiogenesis, and matrix deposition/collagen
synthesis
what are the 4 major phases in full-thickness repair? - ANSWERS-1.
hemostasis (platelets degranulate and release growth factors)
2. inflammatory (leakage of neutrophils, macrophages )
3. proliferative/rebuilding (cont recruitment of growth factors,
granulation formation, contraction of wound edges, epithelial
resurfacing)
4. maturation/remodeling (collagen synthesis)
granulation tissue is often referred to as - ANSWERS-extracellular
matrix (ECM)
in full-thickness wounds, why is the new epidermis slightly thinner than
original epidermis? - ANSWERS-ret pegs that normall dip into dermis is
lacking
END OF
PAGE
3
, WOUND LATEST
CERTIFICATION
EXAM
In chronic wounds where wound is healing by secondary intention, why
is healing delayed? - ANSWERS-hemostasis is absent, presence of
excess of proinflammartory cells where wound bed is bioburdened,
prolonged proliferative phase where granulation and wound contraction
must take place before epithealization
what are the characteristics of a chronic wound? - ANSWERS-
prolonged inflammatory phase,
cellular senescene, deficiency of growth factor receptor sites, absence of
hemostasis phase which triggers fibrin production and growth factor
release, and high level of proteases
how does diabetes effect repair process? - ANSWERS-prolongs
inflammation, reduces collagen synthesis, decreases tensile strength,
impairs epithelial migration, compromises vasculature
how does advance age affect wound healing? - ANSWERS-dimished
proliferation of cells critical to repair, increased number of senescent
cells, diminished production of growth factors, hormonal changes,
multiple co-existing comorbidities
END OF
PAGE
4
