WGU D027 OBJECTIVE ASSESSMENT (OA) – 2025 EDITION COMPREHENSIVE HUMAN GENETICS, DISORDERS, AND CLINICAL MANAGEMENT PRACTICE EXAM | 130 QUESTIONS WITH ANSWERS & RATIONALES

WGU D027 OBJECTIVE ASSESSMENT (OA) – 2025 EDITION
COMPREHENSIVE HUMAN GENETICS, DISORDERS, AND
CLINICAL MANAGEMENT PRACTICE EXAM | 130
QUESTIONS WITH ANSWERS & RATIONALES

Includes Genetics, Hematology, Respiratory, Metabolic Disorders, Medications, Lab
Diagnostics, and Scenario-Based Clinical Questions




Q1. What organ does cystic fibrosis primarily affect?

 A) Liver
 B) Lungs and pancreas
 C) Heart
 D) Kidneys
Explanation: Cystic fibrosis causes thick mucus obstructing the lungs
(respiratory issues) and pancreas (digestive enzyme blockage).

Q2. What is Klinefelter syndrome?

 A) Males with an extra X chromosome (XXY), causing female-like
traits)
 B) Females with missing X chromosome
 C) A mutation in the CFTR gene
 D) Increased beta-globin production
Explanation: XXY males may show gynecomastia, infertility, and low
testosterone.

Q3. What is Turner syndrome?

 A) Females with a missing or deformed X chromosome
 B) Males with extra X chromosome
 C) Overproduction of hemoglobin
 D) A type of cystic fibrosis
Explanation: Turner syndrome causes short stature, ovarian failure, and
sometimes hearing and attentional problems.

Q4. What is beta thalassemia?

,  A) A condition with decreased or absent beta-globin chains, causing
anemia
 B) Excess alpha-globin production
 C) A lung disorder
 D) A type of diabetes
Explanation: Leads to microcytic anemia and low hemoglobin; patients
often require transfusions.

Q5. Which medication is contraindicated in beta thalassemia?

 A) Folic acid
 B) Ferrous sulfate
 C) Hydroxyurea
 D) Vitamin B12
Explanation: Iron supplements worsen iron overload in these patients.



Hematology & Blood Disorders

Q6. Sickle cell anemia is caused by:

 A) A mutation in the beta-globin gene producing abnormal hemoglobin
S
 B) Excess alpha-globin chains
 C) A defect in platelet production
 D) A mutation in the CFTR gene
Explanation: HbS causes red blood cells to sickle, leading to vaso-
occlusion and anemia.

Q7. Symptoms of sickle cell anemia include:

 A) Hyperpigmentation
 B) Pain crises, fatigue, and risk of stroke
 C) Excessive bleeding only
 D) Kidney failure exclusively
Explanation: Sickled cells block vessels, causing pain, organ damage, and
anemia-related fatigue.

Q8. Which lab finding is typical for iron deficiency anemia?

,  A) High MCV
 B) Low hemoglobin and low MCV
 C) Elevated hemoglobin A1C
 D) Increased WBC count
Explanation: Iron deficiency causes microcytic anemia (low MCV) and
low hemoglobin.

Q9. Which type of anemia is caused by vitamin B12 deficiency?

 A) Megaloblastic anemia
 B) Iron deficiency anemia
 C) Hemolytic anemia
 D) Aplastic anemia
Explanation: B12 deficiency impairs DNA synthesis, producing large,
immature RBCs.

Q10. A patient with anemia has jaundice, fatigue, and enlarged spleen. Which type
is likely?

 A) Iron deficiency
 B) Hemolytic anemia
 C) Pernicious anemia
 D) Beta thalassemia minor
Explanation: Hemolytic anemia involves premature RBC destruction
causing jaundice and splenomegaly.



Respiratory Disorders

Q11. In cystic fibrosis, thick mucus in the lungs causes:

 A) Asthma only
 B) Chronic infections and bronchiectasis
 C) Tuberculosis
 D) Pulmonary embolism
Explanation: Obstructed airways trap bacteria, leading to repeated
infections.

Q12. Which is a common CF-related digestive problem?