1. Naloxone (Narcan): Opioid antagonist that blocks effects of opioids, including CNS and respiratory depres-
sion, without producing any agonist (opioid-like) effects.
2. Naloxone (Narcan) - Reason for Med: Reversal of CNS depression and respiratory depression
because of suspected opioid overdose.
3. Naloxone (Narcan) - Side Effects: Ventricular arrhythmias, hypertension, hypotension, nausea/vom-
iting, pulmonary edema, withdrawal.
4. Naloxone (Narcan) - Nursing Consideration: Monitor respiratory rate, rhythm, and pulse. Check
LOC frequently for 3-4 hours after expected peak. Assess s/sx of opioid withdrawal (vomiting, restlessness, ^BP, and
temp).
5. Naltrexone (ReVia): Opioid antagonist that blocks the effects of opioids, including CNS and respiratory
depression, without producing any agonist (opioid-like) effects.
6. Naltrexone (ReVia) - Reason for Med: Maintenance of opioid free state/Management of opioid
and alcohol dependence.
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, 7. Naltrexone (ReVia) - Side Effects: Nausea, vomiting, anxiety, fatigue, headache, insomnia, nervous-
ness, abdominal pain, pulmonary edema, withdrawal.
8. Naltrexone (ReVia) - Nursing Consideration: Monitor closely for changes in behavior such as
suicidal thoughts, behavior or depression. Assess patient for last time opioids or alcohol were taken. Patient must be
free from opioids for 7 to 10 days prior to treatment.
9. Acamprosate (Campral): Gamma aminobutyric acid GABA analogues that interact with and restore
balance to CNS glutamate and GABA neurotransmitter systems.
10. Acamprosate (Campral) - Reason for Med: Stabilizes signals in the brain to help abstain from
alcohol.
11. Acamprosate (Campral) - Side Effects: Headache, anxiety, depression, drowsiness, palpitations,
syncope.
12. Acamprosate (Campral) - Nursing Consideration: Assess for signs of alcohol withdrawal at
initiation of therapy. Take as directed even in case of relapse. Avoid driving/alert activities until response to med is
known. Continue counseling/support.
13. Disulfiram (Antabuse): Enzyme inhibitor that inhibits the enzyme aldehyde dehydrogenase, resulting in
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