CANCER CLASS LECTURE 10 (EXAM 1)
2025/2026 QUESTIONS AND ANSWERS
100% PASS
Tumor cells - ANS Involves one cell type
Paget's seed and soil hypothesis - ANS Particularly important in metastasis but also relevant
to primary tumors
Stroma (connective and supportive tissue) - ANS Provides a microenvironment (the so-called
congenial soil)
Tumors - ANS Manipulate the stroma to get the nutrients and to remain protected from the
immune system
Components of tumor microenvironment - ANS Extracellular matrix, fibroblasts, pericytes
and endothelial cells, innate immune cells, adaptive immune cells
Extra cellular matrix - ANS Acellular
Fibroblasts - ANS Predominant cell of the connective tissue
Pericytes and endothelial cells - ANS Components of blood vessels
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
, Innate immune cells - ANS Macrophages, dendritic cells, etc.
Adaptive immune cells - ANS Regulatory T cells
Extracellular matrix importance - ANS Determines the arrangement of cells in tissues
Basement membrane - ANS Anchors epithelial tissues
Invasive tumors - ANS Break through the basement membrane and then it must navigate and
remodel the interstitial extracellular matrix to further invade into the organ
Matrix metalloproteinanses (MMPs) - ANS ECM remodeling enzymes
MMP inhibitors - ANS Have been invested in clinical trials, but all have failed
Fibroblast structure and function - ANS Connective tissue that produces/arranges the
extracellular matrix, coordinates growth of other cells through growth factors, influences
immune cell recruitment, and moves toward sites of injury
Cancer-associated fibroblasts - ANS Are similar to activated fibroblasts during wound healing
(can secrete growth factors/influence immune system activity to aid tumor growth and
contribute to drug resistance
Epithelial to mesenchymal transition - ANS Can be necessary for invasion and metastasis; can
be mediated by fibroblasts
Two types of cancer-associated immune cells - ANS Innate and adaptive immune cells
Innate immunity - ANS Scavengers and primers for the adaptive immune cells
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
2025/2026 QUESTIONS AND ANSWERS
100% PASS
Tumor cells - ANS Involves one cell type
Paget's seed and soil hypothesis - ANS Particularly important in metastasis but also relevant
to primary tumors
Stroma (connective and supportive tissue) - ANS Provides a microenvironment (the so-called
congenial soil)
Tumors - ANS Manipulate the stroma to get the nutrients and to remain protected from the
immune system
Components of tumor microenvironment - ANS Extracellular matrix, fibroblasts, pericytes
and endothelial cells, innate immune cells, adaptive immune cells
Extra cellular matrix - ANS Acellular
Fibroblasts - ANS Predominant cell of the connective tissue
Pericytes and endothelial cells - ANS Components of blood vessels
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
, Innate immune cells - ANS Macrophages, dendritic cells, etc.
Adaptive immune cells - ANS Regulatory T cells
Extracellular matrix importance - ANS Determines the arrangement of cells in tissues
Basement membrane - ANS Anchors epithelial tissues
Invasive tumors - ANS Break through the basement membrane and then it must navigate and
remodel the interstitial extracellular matrix to further invade into the organ
Matrix metalloproteinanses (MMPs) - ANS ECM remodeling enzymes
MMP inhibitors - ANS Have been invested in clinical trials, but all have failed
Fibroblast structure and function - ANS Connective tissue that produces/arranges the
extracellular matrix, coordinates growth of other cells through growth factors, influences
immune cell recruitment, and moves toward sites of injury
Cancer-associated fibroblasts - ANS Are similar to activated fibroblasts during wound healing
(can secrete growth factors/influence immune system activity to aid tumor growth and
contribute to drug resistance
Epithelial to mesenchymal transition - ANS Can be necessary for invasion and metastasis; can
be mediated by fibroblasts
Two types of cancer-associated immune cells - ANS Innate and adaptive immune cells
Innate immunity - ANS Scavengers and primers for the adaptive immune cells
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
