IMMUNOLOGY TEST BANK EXAM
2025/2026 QUESTIONS AND ANSWERS
100% PASS
The germinal centers found in the cortical region of lymph nodes and the peripheral region of
splenic periarteriolar lymphatic tissue: - ANS contains large populations of B lymphocytes
and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular infections.
Thus, in case of Mycobacterium leprae infection: - ANS tuberculoid leprosy will occur in
patients with a prominent TH1 response
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The MHC molecule located around the peptide-binding cleft is recognized by the: -
ANS CD4 or CD8 molecules
The edema occurring in the inflammatory process is the result of all the following factors
EXCEPT: - ANS neural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - ANS recognize pathogen-associated molecular patterns (PAMPs)
on selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The T cell receptor transduction molecule(s) is(are) conducted by: - ANS CD3 and ζ
molecules
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
,Which of the following is considered a primary lymphoid organ? - ANS thymus
Immediate activation of the B lymphocytes following contact with the antigen involves all of the
following molecules EXCEPT: - ANS MHC class II molecules
Immunologic memory refers to: - ANS changes in adaptive immune responses with
subsequent encounters with antigen
Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (HEVs)? - ANS L-selectin
The main consequences of complement activation are all of the following EXCEPT: -
ANS producing 2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - ANS dendritic cells located
mainly in the epidermis
All of the following cells results in the germinal center reaction of the follicles (B lymphocyte
zone) EXCEPT: - ANS short-lived plasma cells
The antigen recognition on the T cells is mediated by: - ANS the Variable (v) regions of α and
β chains
The T-cell receptor: - ANS recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? -
ANS Clones of lymphocytes specific for antigens develop prior to exposure to the antigens
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
, Which of the following best describes the T-dependent antibody response? - ANS IT is the
response of follicular B lymphocytes to a protein antigen and characterized by isotope-
switched, high affinity antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - ANS One α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all of the
following EXCEPT: - ANS antigen presentation to the T cells in the follicles of the lymph nodes
The phases and order of the specific or acquired immune responses are: - ANS recognition
phase; activation phase; effector phase; homeostasis phase; memory phase
A naive CD4+ T cell may differentiate into subsets that produce different cytokines that recruit
and activate different cell types. The IFN-γ is produced mainly by: - ANS CD4+ T cell TH1
subset
TH1 subset effector cells that aid in cell mediated immune response activate the macrophage
and B lymphocytes by: - ANS CD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D, and J
gene segments in different clones of lymphocytes is the result of: - ANS both combinatorial
diversity and junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: -
ANS recognizes antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal was
infected with rabies virus, is administration of human immunoglobulin preparations containing
anti-rabies virus antibodies. Which type of immunity would be established by this treatment? -
ANS passive humoral immunity
3 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
2025/2026 QUESTIONS AND ANSWERS
100% PASS
The germinal centers found in the cortical region of lymph nodes and the peripheral region of
splenic periarteriolar lymphatic tissue: - ANS contains large populations of B lymphocytes
and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular infections.
Thus, in case of Mycobacterium leprae infection: - ANS tuberculoid leprosy will occur in
patients with a prominent TH1 response
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The MHC molecule located around the peptide-binding cleft is recognized by the: -
ANS CD4 or CD8 molecules
The edema occurring in the inflammatory process is the result of all the following factors
EXCEPT: - ANS neural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - ANS recognize pathogen-associated molecular patterns (PAMPs)
on selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The T cell receptor transduction molecule(s) is(are) conducted by: - ANS CD3 and ζ
molecules
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
,Which of the following is considered a primary lymphoid organ? - ANS thymus
Immediate activation of the B lymphocytes following contact with the antigen involves all of the
following molecules EXCEPT: - ANS MHC class II molecules
Immunologic memory refers to: - ANS changes in adaptive immune responses with
subsequent encounters with antigen
Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (HEVs)? - ANS L-selectin
The main consequences of complement activation are all of the following EXCEPT: -
ANS producing 2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - ANS dendritic cells located
mainly in the epidermis
All of the following cells results in the germinal center reaction of the follicles (B lymphocyte
zone) EXCEPT: - ANS short-lived plasma cells
The antigen recognition on the T cells is mediated by: - ANS the Variable (v) regions of α and
β chains
The T-cell receptor: - ANS recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? -
ANS Clones of lymphocytes specific for antigens develop prior to exposure to the antigens
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
, Which of the following best describes the T-dependent antibody response? - ANS IT is the
response of follicular B lymphocytes to a protein antigen and characterized by isotope-
switched, high affinity antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - ANS One α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all of the
following EXCEPT: - ANS antigen presentation to the T cells in the follicles of the lymph nodes
The phases and order of the specific or acquired immune responses are: - ANS recognition
phase; activation phase; effector phase; homeostasis phase; memory phase
A naive CD4+ T cell may differentiate into subsets that produce different cytokines that recruit
and activate different cell types. The IFN-γ is produced mainly by: - ANS CD4+ T cell TH1
subset
TH1 subset effector cells that aid in cell mediated immune response activate the macrophage
and B lymphocytes by: - ANS CD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D, and J
gene segments in different clones of lymphocytes is the result of: - ANS both combinatorial
diversity and junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: -
ANS recognizes antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal was
infected with rabies virus, is administration of human immunoglobulin preparations containing
anti-rabies virus antibodies. Which type of immunity would be established by this treatment? -
ANS passive humoral immunity
3 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED
