TEST BANK mj
Cellular and Molecular Immunology
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Abul Abbas, Andrew Lichtman, and Shiv Pillai
mj mj mj mj mj mj
10th Edition
mj
,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
mj mj mj mj mj mj mj 1
Chapter 02 Cells and Tissues of the Immune System
mj mj mj mj mj mj mj mj 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
mj mj mj mj mj mj mj 6
Chapter 04 Innate Immunity
mj mj mj 10
Chapter 05 Antibodies and Antigens
mj mj mj mj 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
mj mj mj mj mj mj mj mj mj mj mj
Histocompatibility Complex Molecules
mj mj 20
Chapter 07 Immune Receptors and Signal Transduction
mj mj mj mj mj mj 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
mj mj mj mj mj mj mj mj 30
Chapter 09 Activation of T Lymphocytes
mj mj mj mj mj 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
mj mj mj mj mj mj mj mj mj 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
mj mj mj mj mj mj mj mj mj 42
Chapter 12 B Cell Activation and Antibody Production
mj mj mj mj mj mj mj 46
Chapter 13 Effector Mechanisms of Humoral Immunity
mj mj mj mj mj mj 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
mj mj mj mj mj mj mj mj mj mj mj 56
Chapter 15 Immunologic Tolerance and Autoimmunity
mj mj mj mj mj 62
Chapter 16 Immunity to Microbes
mj mj mj mj 67
Chapter 17 Transplantation Immunology
mj mj mj 72
Chapter 18 Tumor Immunology
mj mj mj 77
Chapter 19 Hypersensitivity Disorders
mj mj mj 81
Chapter 20 Allergy
mj mj 86
Chapter 21 Primary and Acquired Immunodeficiencies
mj mj mj mj mj 89
,Chapter 01: Properties and Overview of Immune Responses
mj mj mj mj mj mj mj
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
mj mj mj mj mj mj mj mj mj
MULTIPLE CHOICE mj
1. The principal function of the immune system is:
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a. Defense against cancer mj mj
b. Repair of injured tissues mj mj mj
c. Defense against microbial infections mj mj mj
d. Prevention of inflammatory diseases mj mj mj
e. Protection against environmental toxins mj mj mj
ANS: C m j
The immune system has evolved in the setting of selective pressures imposed by microbi
mj mj mj mj mj mj mj mj mj mj mj mj mj
al infections. Although immune responses to cancer may occur, the concept that ―immu
mj mj mj mj mj mj mj mj mj mj mj mj
nosurveillance‖ against cancer is a principal function of the immune system is controver
mj mj mj mj mj mj mj mj mj mj mj mj
sial. Repair of injured tissues may be a secondary consequence of the immune response
mj mj mj mj mj mj mj mj mj mj mj mj mj
s and inflammation. Although the immune system has regulatory features that are neede
mj mj mj mj mj mj mj mj mj mj mj mj
d to prevent excessive inflammation, prevention of inflammatory diseases is not a prima
mj mj mj mj mj mj mj mj mj mj mj mj
ry function. The immune system can protect against microbial toxins, but it generally doe
mj mj mj mj mj mj mj mj mj mj mj mj mj
s not offer protection against toxins of nonbiologic origin.
mj mj mj mj mj mj mj mj
2. Which of the following infectious diseases was prevented by the first successf
mj mj mj mj mj mj mj mj mj mj mj
ul vaccination?
mj
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C m j
In 1798, Edward Jenner reported the first intentional successful vaccination, which was
mj mj mj mj mj mj mj mj mj mj mj mj
against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 19
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
80, smallpox was reported to be eradicated worldwide by a vaccination program. Effecti
mj mj mj mj mj mj mj mj mj mj mj mj
ve vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20
mj mj mj mj mj mj mj mj mj mj mj mj mj
th century and are widely used. There is no effective vaccine against Mycobacterium tu
mj mj mj mj mj mj mj mj mj mj mj mj mj
berculosis.
3. Which of the following is a unique property of the adaptive immune system?
mj mj mj mj mj mj mj mj mj mj mj mj
a. Highly diverse repertoire of specificities for antigens
mj mj mj mj mj mj
b. Self-nonself discrimination mj
c. Recognition of microbial structures by both cell-associated and soluble receptors
mj mj mj mj mj mj mj mj mj
d. Protection against viral infections mj mj mj
e. Responses that have the same kinetics and magnitude on repeated exposure to t
mj mj mj mj mj mj mj mj mj mj mj mj
he same microbe mj mj
ANS: m j A
, Highly diverse repertoires of specificities for antigens are found only in T and B lymph
mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ocytes, which are the central cellular components of the adaptive immune system. Both
mj mj mj mj mj mj mj mj mj mj mj mj mj
the innate and the adaptive immune systems use cell-
mj mj mj mj mj mj mj mj
associated and soluble receptors to recognize microbes, display some degree of self-
mj mj mj mj mj mj mj mj mj mj mj
nonself discrimination, and protect against viruses. On repeated exposure to the same mi
mj mj mj mj mj mj mj mj mj mj mj mj
crobe, the adaptive immune response becomes more rapid and of greater magnitude; this
mj mj mj mj mj mj mj mj mj mj mj mj
is the manifestation of memory.
mj mj mj mj mj
4. Antibodies and T lymphocytes are the respective mediators of which two types
mj mj mj mj mj mj mj mj mj mj mj mj
of immunity?
mj
a. Innate and adaptive mj mj
b. Passive and active mj mj
c. Specific and nonspecific mj mj
d. Humoral and cell-mediated mj mj
e. Adult and neonatal mj mj
ANS: D m j
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyt
mj mj mj mj mj mj mj mj mj mj mj mj
es produce antibodies, which are the recognition and effector molecules of humoral imm
mj mj mj mj mj mj mj mj mj mj mj mj
une responses to extracellular pathogens. T cells recognize and promote eradication of int
mj mj mj mj mj mj mj mj mj mj mj mj
racellular pathogens in cell- mj mj mj
mediated immunity. Passive and active immunity both can be mediated by either B or T l
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ymphocytes. Specific immunity is another term for adaptive immunity. Both B and T lym
mj mj mj mj mj mj mj mj mj mj mj mj mj
phocytes participate in adult adaptive immunity but are still developing in the neonatal p
mj mj mj mj mj mj mj mj mj mj mj mj mj
eriod.
5. The two major functional classes of effector T lymphocytes are:
mj mj mj mj mj mj mj mj mj
a. Helper T lymphocytes and cytotoxic T lymphocytes
mj mj mj mj mj mj
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
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c. Memory T cells and effector T cells mj mj mj mj mj mj
d. Helper cells and antigen-presenting cells mj mj mj mj
e. Cytotoxic T lymphocytes and target cells mj mj mj mj mj
ANS: A m j
T cells can be classified into effector subsets that perform different effector functions. M
mj mj mj mj mj mj mj mj mj mj mj mj mj
ost effector T cells are either helper T lymphocytes, which enhance the responses of oth
mj mj mj mj mj mj mj mj mj mj mj mj mj mj
er immune cells, including phagocytes and B cells, to infections, or cytotoxic T lympho
mj mj mj mj mj mj mj mj mj mj mj mj mj
cytes, which directly kill infected cells. Natural killer cells are not T lymphocytes.
mj mj mj mj mj mj mj mj mj mj mj mj
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. mj mj mj mj mj mj mj mj mj mj mj mj mj mj
6. Which of the following cell types is required for all adaptive humoral immune responses?
mj mj mj mj mj mj mj mj mj mj mj mj mj
a. Natural killer cells mj mj
b. Dendritic cells mj
c. Cytolytic T lymphocytes mj mj
d. B lymphocytes mj
e. Helper T lymphocytes mj mj
ANS: D m j
Humoral immune responses are antibody- mj mj mj mj
mediated immune responses, and all antibodies are made by B lymphocytes and no ot
mj mj mj mj mj mj mj mj mj mj mj mj mj
her cell type.
mj mj
Cellular and Molecular Immunology
mj mj mj
Abul Abbas, Andrew Lichtman, and Shiv Pillai
mj mj mj mj mj mj
10th Edition
mj
,Table of Contents
mj mj
Chapter 01 Properties and Overview of Immune Responses
mj mj mj mj mj mj mj 1
Chapter 02 Cells and Tissues of the Immune System
mj mj mj mj mj mj mj mj 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
mj mj mj mj mj mj mj 6
Chapter 04 Innate Immunity
mj mj mj 10
Chapter 05 Antibodies and Antigens
mj mj mj mj 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
mj mj mj mj mj mj mj mj mj mj mj
Histocompatibility Complex Molecules
mj mj 20
Chapter 07 Immune Receptors and Signal Transduction
mj mj mj mj mj mj 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
mj mj mj mj mj mj mj mj 30
Chapter 09 Activation of T Lymphocytes
mj mj mj mj mj 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
mj mj mj mj mj mj mj mj mj 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
mj mj mj mj mj mj mj mj mj 42
Chapter 12 B Cell Activation and Antibody Production
mj mj mj mj mj mj mj 46
Chapter 13 Effector Mechanisms of Humoral Immunity
mj mj mj mj mj mj 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
mj mj mj mj mj mj mj mj mj mj mj 56
Chapter 15 Immunologic Tolerance and Autoimmunity
mj mj mj mj mj 62
Chapter 16 Immunity to Microbes
mj mj mj mj 67
Chapter 17 Transplantation Immunology
mj mj mj 72
Chapter 18 Tumor Immunology
mj mj mj 77
Chapter 19 Hypersensitivity Disorders
mj mj mj 81
Chapter 20 Allergy
mj mj 86
Chapter 21 Primary and Acquired Immunodeficiencies
mj mj mj mj mj 89
,Chapter 01: Properties and Overview of Immune Responses
mj mj mj mj mj mj mj
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
mj mj mj mj mj mj mj mj mj
MULTIPLE CHOICE mj
1. The principal function of the immune system is:
mj mj mj mj mj mj mj
a. Defense against cancer mj mj
b. Repair of injured tissues mj mj mj
c. Defense against microbial infections mj mj mj
d. Prevention of inflammatory diseases mj mj mj
e. Protection against environmental toxins mj mj mj
ANS: C m j
The immune system has evolved in the setting of selective pressures imposed by microbi
mj mj mj mj mj mj mj mj mj mj mj mj mj
al infections. Although immune responses to cancer may occur, the concept that ―immu
mj mj mj mj mj mj mj mj mj mj mj mj
nosurveillance‖ against cancer is a principal function of the immune system is controver
mj mj mj mj mj mj mj mj mj mj mj mj
sial. Repair of injured tissues may be a secondary consequence of the immune response
mj mj mj mj mj mj mj mj mj mj mj mj mj
s and inflammation. Although the immune system has regulatory features that are neede
mj mj mj mj mj mj mj mj mj mj mj mj
d to prevent excessive inflammation, prevention of inflammatory diseases is not a prima
mj mj mj mj mj mj mj mj mj mj mj mj
ry function. The immune system can protect against microbial toxins, but it generally doe
mj mj mj mj mj mj mj mj mj mj mj mj mj
s not offer protection against toxins of nonbiologic origin.
mj mj mj mj mj mj mj mj
2. Which of the following infectious diseases was prevented by the first successf
mj mj mj mj mj mj mj mj mj mj mj
ul vaccination?
mj
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C m j
In 1798, Edward Jenner reported the first intentional successful vaccination, which was
mj mj mj mj mj mj mj mj mj mj mj mj
against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 19
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
80, smallpox was reported to be eradicated worldwide by a vaccination program. Effecti
mj mj mj mj mj mj mj mj mj mj mj mj
ve vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20
mj mj mj mj mj mj mj mj mj mj mj mj mj
th century and are widely used. There is no effective vaccine against Mycobacterium tu
mj mj mj mj mj mj mj mj mj mj mj mj mj
berculosis.
3. Which of the following is a unique property of the adaptive immune system?
mj mj mj mj mj mj mj mj mj mj mj mj
a. Highly diverse repertoire of specificities for antigens
mj mj mj mj mj mj
b. Self-nonself discrimination mj
c. Recognition of microbial structures by both cell-associated and soluble receptors
mj mj mj mj mj mj mj mj mj
d. Protection against viral infections mj mj mj
e. Responses that have the same kinetics and magnitude on repeated exposure to t
mj mj mj mj mj mj mj mj mj mj mj mj
he same microbe mj mj
ANS: m j A
, Highly diverse repertoires of specificities for antigens are found only in T and B lymph
mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ocytes, which are the central cellular components of the adaptive immune system. Both
mj mj mj mj mj mj mj mj mj mj mj mj mj
the innate and the adaptive immune systems use cell-
mj mj mj mj mj mj mj mj
associated and soluble receptors to recognize microbes, display some degree of self-
mj mj mj mj mj mj mj mj mj mj mj
nonself discrimination, and protect against viruses. On repeated exposure to the same mi
mj mj mj mj mj mj mj mj mj mj mj mj
crobe, the adaptive immune response becomes more rapid and of greater magnitude; this
mj mj mj mj mj mj mj mj mj mj mj mj
is the manifestation of memory.
mj mj mj mj mj
4. Antibodies and T lymphocytes are the respective mediators of which two types
mj mj mj mj mj mj mj mj mj mj mj mj
of immunity?
mj
a. Innate and adaptive mj mj
b. Passive and active mj mj
c. Specific and nonspecific mj mj
d. Humoral and cell-mediated mj mj
e. Adult and neonatal mj mj
ANS: D m j
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyt
mj mj mj mj mj mj mj mj mj mj mj mj
es produce antibodies, which are the recognition and effector molecules of humoral imm
mj mj mj mj mj mj mj mj mj mj mj mj
une responses to extracellular pathogens. T cells recognize and promote eradication of int
mj mj mj mj mj mj mj mj mj mj mj mj
racellular pathogens in cell- mj mj mj
mediated immunity. Passive and active immunity both can be mediated by either B or T l
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ymphocytes. Specific immunity is another term for adaptive immunity. Both B and T lym
mj mj mj mj mj mj mj mj mj mj mj mj mj
phocytes participate in adult adaptive immunity but are still developing in the neonatal p
mj mj mj mj mj mj mj mj mj mj mj mj mj
eriod.
5. The two major functional classes of effector T lymphocytes are:
mj mj mj mj mj mj mj mj mj
a. Helper T lymphocytes and cytotoxic T lymphocytes
mj mj mj mj mj mj
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
mj mj mj mj
c. Memory T cells and effector T cells mj mj mj mj mj mj
d. Helper cells and antigen-presenting cells mj mj mj mj
e. Cytotoxic T lymphocytes and target cells mj mj mj mj mj
ANS: A m j
T cells can be classified into effector subsets that perform different effector functions. M
mj mj mj mj mj mj mj mj mj mj mj mj mj
ost effector T cells are either helper T lymphocytes, which enhance the responses of oth
mj mj mj mj mj mj mj mj mj mj mj mj mj mj
er immune cells, including phagocytes and B cells, to infections, or cytotoxic T lympho
mj mj mj mj mj mj mj mj mj mj mj mj mj
cytes, which directly kill infected cells. Natural killer cells are not T lymphocytes.
mj mj mj mj mj mj mj mj mj mj mj mj
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. mj mj mj mj mj mj mj mj mj mj mj mj mj mj
6. Which of the following cell types is required for all adaptive humoral immune responses?
mj mj mj mj mj mj mj mj mj mj mj mj mj
a. Natural killer cells mj mj
b. Dendritic cells mj
c. Cytolytic T lymphocytes mj mj
d. B lymphocytes mj
e. Helper T lymphocytes mj mj
ANS: D m j
Humoral immune responses are antibody- mj mj mj mj
mediated immune responses, and all antibodies are made by B lymphocytes and no ot
mj mj mj mj mj mj mj mj mj mj mj mj mj
her cell type.
mj mj
