N5334 Final Exam Question &
Answers ( Latest 2025 )
Prescribing basics - CORRECT ANSWERS
✔✔Prescribing is regulated by state BON
Proper RX - CORRECT ANSWERS ✔✔Providers name
and address, Telephone
DEA
Pt name/DOB/Addres
Name of Drug, strength, SIG(directions) with
indication/Route and frequency, Quantity and signature.
Drug Schedules: Most addictive to least - CORRECT
ANSWERS ✔✔1: Heroin,LSD, MJ
2: hydrocodone, cocaine, Methamphetamine, methadone,
oxycodone, meperidine, fentanyl, adderall, ritalin
3: codeine, ketamine, testosterone
4: xanax, valium, soma, ambient, tramadol
5: antidiarrheal, antitussives, lomotil, lyrica
Pharmicodyamics - CORRECT ANSWERS ✔✔The
effects of drug on the body. Receptors are large
molecules usually proteins, that interact and mediate the
action of drugs
,N5334 Final Exam Question &
Answers ( Latest 2025 )
agonist - CORRECT ANSWERS ✔✔produce receptor
stimulation and a conformational change every time they
bind. Do not need all available receptors to produce a
maximum response
Partial agonist - CORRECT ANSWERS ✔✔drugs that
have properties in b/w those of full agonist and
antagonist. They bind to receptors but when they occupy
the receptor sites, they stimulate only some of the
receptors.
antagonist - CORRECT ANSWERS ✔✔drugs with
affinity for a receptor but with no intrinsic activity. Affinity
allows the antagonist to bind to receptors, but lack of
intrinsic activity prevents the bound antagonist from
causing receptor activation. The block action of drugs (ex.
Narcan)
Bioavailabity - CORRECT ANSWERS ✔✔% of
administered dosage of the drug that survives the first
pass through the liver and reaches the blood stream
half life - CORRECT ANSWERS ✔✔Time required for
the amount of a drug in the body to decline by 50%,
drugs with shorter half lives must be administer
,N5334 Final Exam Question &
Answers ( Latest 2025 )
frequently. 4.5-5.5 times the half life to get steady state
and to be limited from the body
what the body does to the drug - CORRECT ANSWERS
✔✔absorption, distribution, metabolism, excretion
Distribution - CORRECT ANSWERS ✔✔movement of
absorbed drug in bodily fluids throughout the body to
target tissue. Properties affecting: lipid/water solubility,
PH affects ionization of drug, protein binding, size of
molecule (smaller molecules are more able to diffuse)
Tissue: fat, bone, blood/brain barrier (only lipid soluble
will pass), placental barrier (many drugs can pass)
Protein binding - CORRECT ANSWERS ✔✔unbound
drug is free which is active, crosses membrane. Low
plasma proteins result in more free drug. Competition:
when 2 highly bound drugs are given it increases the
level of both drugs
Metabolism - CORRECT ANSWERS ✔✔take place in
the liver mostly. Chemical change of a drug structure to:
, N5334 Final Exam Question &
Answers ( Latest 2025 )
Enhance excretion, inactivate the drug, increase
therapeutic action, active a prodrug (inactive until
metabolized in the body into the active compound, ex:
levodopa), increase or decrease toxicity
CYP450 - CORRECT ANSWERS ✔✔enzymes
constitutes the most important of the phase I
metabolizing enzymes (account for about 75% of drug
metabolism in the liver)
Phase 2: conjugation reaction occur leading to large
increases in hydrophilicity of the substrates rendering
them more readily excretable
Substrate - CORRECT ANSWERS ✔✔an agent that is
metabolized by an enzyme into a metabolite and product
and eventually excreted
Inhibitors - CORRECT ANSWERS ✔✔compete with
other drugs for a particular enzyme affecting the
metabolism (decreased) of the substrate and decreases
the excretion of the substrate and increasing the
circulating drug
inducer - CORRECT ANSWERS ✔✔competes with
other drugs for a particular enzyme affecting metabolism
Answers ( Latest 2025 )
Prescribing basics - CORRECT ANSWERS
✔✔Prescribing is regulated by state BON
Proper RX - CORRECT ANSWERS ✔✔Providers name
and address, Telephone
DEA
Pt name/DOB/Addres
Name of Drug, strength, SIG(directions) with
indication/Route and frequency, Quantity and signature.
Drug Schedules: Most addictive to least - CORRECT
ANSWERS ✔✔1: Heroin,LSD, MJ
2: hydrocodone, cocaine, Methamphetamine, methadone,
oxycodone, meperidine, fentanyl, adderall, ritalin
3: codeine, ketamine, testosterone
4: xanax, valium, soma, ambient, tramadol
5: antidiarrheal, antitussives, lomotil, lyrica
Pharmicodyamics - CORRECT ANSWERS ✔✔The
effects of drug on the body. Receptors are large
molecules usually proteins, that interact and mediate the
action of drugs
,N5334 Final Exam Question &
Answers ( Latest 2025 )
agonist - CORRECT ANSWERS ✔✔produce receptor
stimulation and a conformational change every time they
bind. Do not need all available receptors to produce a
maximum response
Partial agonist - CORRECT ANSWERS ✔✔drugs that
have properties in b/w those of full agonist and
antagonist. They bind to receptors but when they occupy
the receptor sites, they stimulate only some of the
receptors.
antagonist - CORRECT ANSWERS ✔✔drugs with
affinity for a receptor but with no intrinsic activity. Affinity
allows the antagonist to bind to receptors, but lack of
intrinsic activity prevents the bound antagonist from
causing receptor activation. The block action of drugs (ex.
Narcan)
Bioavailabity - CORRECT ANSWERS ✔✔% of
administered dosage of the drug that survives the first
pass through the liver and reaches the blood stream
half life - CORRECT ANSWERS ✔✔Time required for
the amount of a drug in the body to decline by 50%,
drugs with shorter half lives must be administer
,N5334 Final Exam Question &
Answers ( Latest 2025 )
frequently. 4.5-5.5 times the half life to get steady state
and to be limited from the body
what the body does to the drug - CORRECT ANSWERS
✔✔absorption, distribution, metabolism, excretion
Distribution - CORRECT ANSWERS ✔✔movement of
absorbed drug in bodily fluids throughout the body to
target tissue. Properties affecting: lipid/water solubility,
PH affects ionization of drug, protein binding, size of
molecule (smaller molecules are more able to diffuse)
Tissue: fat, bone, blood/brain barrier (only lipid soluble
will pass), placental barrier (many drugs can pass)
Protein binding - CORRECT ANSWERS ✔✔unbound
drug is free which is active, crosses membrane. Low
plasma proteins result in more free drug. Competition:
when 2 highly bound drugs are given it increases the
level of both drugs
Metabolism - CORRECT ANSWERS ✔✔take place in
the liver mostly. Chemical change of a drug structure to:
, N5334 Final Exam Question &
Answers ( Latest 2025 )
Enhance excretion, inactivate the drug, increase
therapeutic action, active a prodrug (inactive until
metabolized in the body into the active compound, ex:
levodopa), increase or decrease toxicity
CYP450 - CORRECT ANSWERS ✔✔enzymes
constitutes the most important of the phase I
metabolizing enzymes (account for about 75% of drug
metabolism in the liver)
Phase 2: conjugation reaction occur leading to large
increases in hydrophilicity of the substrates rendering
them more readily excretable
Substrate - CORRECT ANSWERS ✔✔an agent that is
metabolized by an enzyme into a metabolite and product
and eventually excreted
Inhibitors - CORRECT ANSWERS ✔✔compete with
other drugs for a particular enzyme affecting the
metabolism (decreased) of the substrate and decreases
the excretion of the substrate and increasing the
circulating drug
inducer - CORRECT ANSWERS ✔✔competes with
other drugs for a particular enzyme affecting metabolism
