Treatment for barbituate OD
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1) manage airway
2) gastric lavage or pharm-induced emesis if ingested <6 hours
3) manage hypothermia
4) manage hypotension
, 5) forced diuresis and alkylization of urine for phenobarbital
Angioedema
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Acquired or hereditary
-> face, mouth, peri-airway tissue
Hereditary angioedema
-> autosomal dominant
-> episodes of life-threathening angioedema
-> abdominal pain
***will not respond to epi or antihistamines; FFP instead... thought to
supply depleted C1 esterase inhibitors or complement components
Describe subtypes and function of the serotonin receptor
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7 families; regulates diverse number of processes
Raphe nuclei - cerebellum, cortex, spinal cord
5HT1A
5HT2A
5HT3
Bupropion (Wellbutrin)
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Norepinephrine dopamine reuptake inhibitor
***most commonly prescribed treatment for depressive disorders and
smoking cessation
-> ADHD treatment
***seizures have been reported
***avoid with MAOIs
MAOI overdose
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-> excessive SNS, seizures, coma
Treatment
- gastric lavage
- dantrolene can aid muscle rigidity
Type V Hypersensitivity
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Less understood; autoantibodies bind and stimulate specific cells
Examples:
1) Grave's disease (TSH stimulation)
, Anesthesia considerations for marijuana use (7)
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1) increases sleep time of barbs and ketamine
2) potentiates non-depolarizers
3) cross-tolerance to opioids, alcohol, barbs, benzo's, phenothiazines
4) NE is potentiated by cannabinoids and THC
***sympathomimetic
5) THC depresses thermoregulation
6) airway irritability and impaired epithelial function
7) Anesthesia should be avoided in pts who have used in the last 72
hours if regional is not an option
Mast cells are located in the ____ (3) and release their contents in the presence of ____.
Basophils are located in the ____.
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Mast cells are located in fixed connective tissue cells in the skin, lungs,
and intestines and release their contents in the presence of IgE
Serotonin multimodal drugs (4)
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1) manage airway
2) gastric lavage or pharm-induced emesis if ingested <6 hours
3) manage hypothermia
4) manage hypotension
, 5) forced diuresis and alkylization of urine for phenobarbital
Angioedema
Give this one a try later!
Acquired or hereditary
-> face, mouth, peri-airway tissue
Hereditary angioedema
-> autosomal dominant
-> episodes of life-threathening angioedema
-> abdominal pain
***will not respond to epi or antihistamines; FFP instead... thought to
supply depleted C1 esterase inhibitors or complement components
Describe subtypes and function of the serotonin receptor
Give this one a try later!
7 families; regulates diverse number of processes
Raphe nuclei - cerebellum, cortex, spinal cord
5HT1A
5HT2A
5HT3
Bupropion (Wellbutrin)
,Give this one a try later!
Norepinephrine dopamine reuptake inhibitor
***most commonly prescribed treatment for depressive disorders and
smoking cessation
-> ADHD treatment
***seizures have been reported
***avoid with MAOIs
MAOI overdose
Give this one a try later!
-> excessive SNS, seizures, coma
Treatment
- gastric lavage
- dantrolene can aid muscle rigidity
Type V Hypersensitivity
Give this one a try later!
Less understood; autoantibodies bind and stimulate specific cells
Examples:
1) Grave's disease (TSH stimulation)
, Anesthesia considerations for marijuana use (7)
Give this one a try later!
1) increases sleep time of barbs and ketamine
2) potentiates non-depolarizers
3) cross-tolerance to opioids, alcohol, barbs, benzo's, phenothiazines
4) NE is potentiated by cannabinoids and THC
***sympathomimetic
5) THC depresses thermoregulation
6) airway irritability and impaired epithelial function
7) Anesthesia should be avoided in pts who have used in the last 72
hours if regional is not an option
Mast cells are located in the ____ (3) and release their contents in the presence of ____.
Basophils are located in the ____.
Give this one a try later!
Mast cells are located in fixed connective tissue cells in the skin, lungs,
and intestines and release their contents in the presence of IgE
Serotonin multimodal drugs (4)
Give this one a try later!
