ONS Chemotherapy Immunotherapy Certificate Exam Questions
and Answers Rated A
Define neoadjuvant therapy - ANSWER -
Treatment is given prior to surgery to shrink the
tumor These agents are typically categorized as highly
emetogenic: - ANSWER -1. Alkylating
agents
Define adjuvant therapy - ANSWER - 2. Nitrosoureas
Additional cancer treatment given after the
primary treatment to lower the risk that the
cancer reoccur Pre-administration labs for alkylating agents and
nitrosoureas: - ANSWER -BUN
Creatinine
3 subcategories of alkylating agents: - CBC w/ diff
ANSWER -1. Nitrogen mustards
2. Platinum-based agents (do not possess an
alkyl group but still termed alkylating agents as What is the medication Mesna used for? -
they work similarly) ANSWER -Bladder protectant with
3. Nitrosoureas administration of cyclophosphamide or ifosfamide
Common alkylating agents: - ANSWER - Instruct pts receiving ________ to avoid
Cyclophosphamide (Cytoxan) exposure to cold air and consuming cold fluids for
Ifosfamide (Ifex) 3-4 days following treatment - ANSWER -
Bendamustine (Treanda) Oxaliplatin
Common platinum-based agents: - How do antimetabolites function? -
ANSWER -Cisplatin (Platinol) ANSWER -By blocking DNA and RNA
Carboplatin (Paraplatin) growth by interfering with enzymes needed for
normal cell metabolism
What is unique about nitrosoureas agents? -
ANSWER -Able to cross the blood-brain Antimetabolites work in the ___ phase. -
barrier; can be effective in treating some brain ANSWER -S
tumors
Common side effects of antimetabolites: -
Common nitrosoureas agents: - ANSWER - ANSWER -Myelosuppression
Carmustine (BiCNU) GI toxicities
Lomustine (CeeNu) Photosensitivity
Streptozocin (Zanosar) Hand-foot syndrome
Hypersensitivity can occur with late doses of: - Common antimetabolite drugs: - ANSWER -
ANSWER -Carboplatin Azacitidine
1/9
, ONS Chemotherapy Immunotherapy Certificate Exam Questions
and Answers Rated A
Capecitabine Cardiac function
5-FU Lifetime dose tracking (cardiotoxicity)
Cytarabine
Decitabine
Methotrexate Lifetime dose of doxorubicin should not exceed: -
ANSWER -550 mg/m^2
The institute for Safe Medication Practices
recommends what route of administration for What cardiac protectant medication can be
vincristine? - ANSWER -IV piggyback via administered prior to doxorubicin? -
gravity ANSWER -Dexrazoxane
Anthracycline antitumor abx work by: - Significant side effects of doxorubicin are: -
ANSWER -Interfering with enzymes ANSWER -Cardiotoxicity
necessary for DNA to replicate in ALL phases of N/V
the cell cycle Mucositis
Diarrhea
Severe myelosuppression
The two major classifications of antitumor Hepatic impairment
antibiotics are: - ANSWER -Anthracyclines Secondary cancers
Non-anthracyclines
Monitoring necessary with bleomycin: -
Common anthracycline antitumor abx: - ANSWER -Pulmonary toxicity
ANSWER -Daunorubicin Hypersensitivity reactions (esp. in lymphoma
Doxorubicin patients)
Epirubicin Cutaneous reactions
Idarubicin Lifetime dose tracking (pulmonary toxicity)
The antitumor abx ___________ is not an Pulmonary fibrosis is possible when the lifetime
anthracycline, but has anthracycline-type dose of bleomycin exceeds: - ANSWER -
properties. - ANSWER -Mitoxantrone 400 units
Common non-anthracycline antitumor abx: - What 6 patient characteristics make CINV more
ANSWER -Actinomycin D likely? - ANSWER -1. Younger than 50
Mitomycin C years
Bleomycin 2. Hx of low alcohol intake
3. Female gender
4. Hx of morning sickness during pregnancy
Monitoring necessary with doxorubicin: - 5. Prone to motion sickness
ANSWER -Vesicant --> extravasation 6. Previous chemotherapy
2/9
and Answers Rated A
Define neoadjuvant therapy - ANSWER -
Treatment is given prior to surgery to shrink the
tumor These agents are typically categorized as highly
emetogenic: - ANSWER -1. Alkylating
agents
Define adjuvant therapy - ANSWER - 2. Nitrosoureas
Additional cancer treatment given after the
primary treatment to lower the risk that the
cancer reoccur Pre-administration labs for alkylating agents and
nitrosoureas: - ANSWER -BUN
Creatinine
3 subcategories of alkylating agents: - CBC w/ diff
ANSWER -1. Nitrogen mustards
2. Platinum-based agents (do not possess an
alkyl group but still termed alkylating agents as What is the medication Mesna used for? -
they work similarly) ANSWER -Bladder protectant with
3. Nitrosoureas administration of cyclophosphamide or ifosfamide
Common alkylating agents: - ANSWER - Instruct pts receiving ________ to avoid
Cyclophosphamide (Cytoxan) exposure to cold air and consuming cold fluids for
Ifosfamide (Ifex) 3-4 days following treatment - ANSWER -
Bendamustine (Treanda) Oxaliplatin
Common platinum-based agents: - How do antimetabolites function? -
ANSWER -Cisplatin (Platinol) ANSWER -By blocking DNA and RNA
Carboplatin (Paraplatin) growth by interfering with enzymes needed for
normal cell metabolism
What is unique about nitrosoureas agents? -
ANSWER -Able to cross the blood-brain Antimetabolites work in the ___ phase. -
barrier; can be effective in treating some brain ANSWER -S
tumors
Common side effects of antimetabolites: -
Common nitrosoureas agents: - ANSWER - ANSWER -Myelosuppression
Carmustine (BiCNU) GI toxicities
Lomustine (CeeNu) Photosensitivity
Streptozocin (Zanosar) Hand-foot syndrome
Hypersensitivity can occur with late doses of: - Common antimetabolite drugs: - ANSWER -
ANSWER -Carboplatin Azacitidine
1/9
, ONS Chemotherapy Immunotherapy Certificate Exam Questions
and Answers Rated A
Capecitabine Cardiac function
5-FU Lifetime dose tracking (cardiotoxicity)
Cytarabine
Decitabine
Methotrexate Lifetime dose of doxorubicin should not exceed: -
ANSWER -550 mg/m^2
The institute for Safe Medication Practices
recommends what route of administration for What cardiac protectant medication can be
vincristine? - ANSWER -IV piggyback via administered prior to doxorubicin? -
gravity ANSWER -Dexrazoxane
Anthracycline antitumor abx work by: - Significant side effects of doxorubicin are: -
ANSWER -Interfering with enzymes ANSWER -Cardiotoxicity
necessary for DNA to replicate in ALL phases of N/V
the cell cycle Mucositis
Diarrhea
Severe myelosuppression
The two major classifications of antitumor Hepatic impairment
antibiotics are: - ANSWER -Anthracyclines Secondary cancers
Non-anthracyclines
Monitoring necessary with bleomycin: -
Common anthracycline antitumor abx: - ANSWER -Pulmonary toxicity
ANSWER -Daunorubicin Hypersensitivity reactions (esp. in lymphoma
Doxorubicin patients)
Epirubicin Cutaneous reactions
Idarubicin Lifetime dose tracking (pulmonary toxicity)
The antitumor abx ___________ is not an Pulmonary fibrosis is possible when the lifetime
anthracycline, but has anthracycline-type dose of bleomycin exceeds: - ANSWER -
properties. - ANSWER -Mitoxantrone 400 units
Common non-anthracycline antitumor abx: - What 6 patient characteristics make CINV more
ANSWER -Actinomycin D likely? - ANSWER -1. Younger than 50
Mitomycin C years
Bleomycin 2. Hx of low alcohol intake
3. Female gender
4. Hx of morning sickness during pregnancy
Monitoring necessary with doxorubicin: - 5. Prone to motion sickness
ANSWER -Vesicant --> extravasation 6. Previous chemotherapy
2/9
