PATHO 370 - week 2 Exam with accurate ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
detailed answers ||\\//||
What is type I hypersensitivity and antigen form? - correct answer✔✔IgE and soluble
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
antigen
What is type II hypersensitivity? - correct answer✔✔IgG OR IgM and cell-bound antigen
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is type III hypersensitivity? - correct answer✔✔IgG AND IgM and soluble antigen
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is type IV hypersensitvity? - correct answer✔✔T Cells and soluble or cell-bound
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
antigen
What is type I hypersensitivity mechanism of activation? - correct answer✔✔-Allergen-
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
specific IgE antibodies bind to mast cells via their Fc receptor.
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-When the specific allergen binds to the IgE, cross-linking of IgE induces degranulation of
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
mast cells.
||\\//||
What is type II hypersensitivity mechanism of activation? - correct answer✔✔-IgG or IgM
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
antibody binds to cellular antigen, leading to complement activation and cell lysis.
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-IgG can also mediate ADCC with cytotoxic T cells, natural killer cells, macrophages and
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
neutrophils.
What is type III hypersensitivity mechanism of activation? - correct answer✔✔- Antigen-
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
antibody complexes are deposited on tissues. ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
,- Complement activation provides inflammatory mediators and recruits neutrophils.
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-Enzymes released neutrophils damage tissue. ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is type IV hypersensitivity mechanism of activation? - correct answer✔✔- TH1 cells
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
secrete cytokines, which activate macrophages and cytotoxic T cells.
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is a type I hypersensitivity reaction? - correct answer✔✔- Local and systemic
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
anaphylaxis
-Seasonal hay fever ||\\//|| ||\\//||
- Food allergies
||\\//|| ||\\//||
- Drug allergies
||\\//|| ||\\//||
What is a type II hypersensitivity reaction? - correct answer✔✔- RBC destruction after
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
transfusion with mismatched blood types during hemolytic disease of the newborn
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is a type III hypersensitivity reaction? - correct answer✔✔- Post-streptococcal
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
glomerulonephritis
-Rheumatoid arthritis ||\\//||
-Systemic lupus erythematosus ||\\//|| ||\\//||
, What is a type IV hypersensitivity reaction? - correct answer✔✔- Contact dermatitis
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-Type I diabetes mellitus
||\\//|| ||\\//|| ||\\//||
-Multiple sclerosis ||\\//|| ||\\//||
(slowest)
What is excessive immune response? - correct answer✔✔A type of alteration in immune
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
function: over or hyper-function of immune system
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is deficient immune response? - correct answer✔✔A type of alteration in immune
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
function: ineffective immune response ||\\//|| ||\\//|| ||\\//||
What is autoimmunity? - correct answer✔✔Immune system attacks own tissues
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is the cause of autoimmunity? - correct answer✔✔Abnormal excessive immune
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
responses toward own ||\\//|| ||\\//||
tissues.
What is the MHC gene? (HLA) - correct answer✔✔Appear to increase risk of autoimmune
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
disorders
females at higher risk ||\\//|| ||\\//|| ||\\//||
What is hypersensitivity? - correct answer✔✔-Describes the mechanism of injury
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-May or may not involve autoimmunity
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
detailed answers ||\\//||
What is type I hypersensitivity and antigen form? - correct answer✔✔IgE and soluble
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
antigen
What is type II hypersensitivity? - correct answer✔✔IgG OR IgM and cell-bound antigen
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is type III hypersensitivity? - correct answer✔✔IgG AND IgM and soluble antigen
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is type IV hypersensitvity? - correct answer✔✔T Cells and soluble or cell-bound
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
antigen
What is type I hypersensitivity mechanism of activation? - correct answer✔✔-Allergen-
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
specific IgE antibodies bind to mast cells via their Fc receptor.
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-When the specific allergen binds to the IgE, cross-linking of IgE induces degranulation of
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
mast cells.
||\\//||
What is type II hypersensitivity mechanism of activation? - correct answer✔✔-IgG or IgM
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
antibody binds to cellular antigen, leading to complement activation and cell lysis.
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-IgG can also mediate ADCC with cytotoxic T cells, natural killer cells, macrophages and
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
neutrophils.
What is type III hypersensitivity mechanism of activation? - correct answer✔✔- Antigen-
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
antibody complexes are deposited on tissues. ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
,- Complement activation provides inflammatory mediators and recruits neutrophils.
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-Enzymes released neutrophils damage tissue. ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is type IV hypersensitivity mechanism of activation? - correct answer✔✔- TH1 cells
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
secrete cytokines, which activate macrophages and cytotoxic T cells.
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is a type I hypersensitivity reaction? - correct answer✔✔- Local and systemic
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
anaphylaxis
-Seasonal hay fever ||\\//|| ||\\//||
- Food allergies
||\\//|| ||\\//||
- Drug allergies
||\\//|| ||\\//||
What is a type II hypersensitivity reaction? - correct answer✔✔- RBC destruction after
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
transfusion with mismatched blood types during hemolytic disease of the newborn
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is a type III hypersensitivity reaction? - correct answer✔✔- Post-streptococcal
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
glomerulonephritis
-Rheumatoid arthritis ||\\//||
-Systemic lupus erythematosus ||\\//|| ||\\//||
, What is a type IV hypersensitivity reaction? - correct answer✔✔- Contact dermatitis
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-Type I diabetes mellitus
||\\//|| ||\\//|| ||\\//||
-Multiple sclerosis ||\\//|| ||\\//||
(slowest)
What is excessive immune response? - correct answer✔✔A type of alteration in immune
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
function: over or hyper-function of immune system
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is deficient immune response? - correct answer✔✔A type of alteration in immune
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
function: ineffective immune response ||\\//|| ||\\//|| ||\\//||
What is autoimmunity? - correct answer✔✔Immune system attacks own tissues
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
What is the cause of autoimmunity? - correct answer✔✔Abnormal excessive immune
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
responses toward own ||\\//|| ||\\//||
tissues.
What is the MHC gene? (HLA) - correct answer✔✔Appear to increase risk of autoimmune
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
disorders
females at higher risk ||\\//|| ||\\//|| ||\\//||
What is hypersensitivity? - correct answer✔✔-Describes the mechanism of injury
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
-May or may not involve autoimmunity
||\\//|| ||\\//|| ||\\//|| ||\\//|| ||\\//||
