PROPERTY OF HIGHYIELD HUB CO -DO NOT COPY
TOPIC
A/1
ALLERGY AND ALLERGIC DISEASES
SUMMARY
CONTENTS
1. IgE and IgE mediated allergic diseases
• Caused by activation of mast cells and basophils by antigen bridging IgE bound to their cell
surfaces
• IgE localized in tissues, bound to mast cells through a receptor
,PROPERTY OF HIGHYIELD HUB CO -DO NOT COPY
• When antigen binds, it cross links the IgE receptors causing release of chemical mediators from
mast cells. This is lead to allergic disease
• A predisposition to become IgE sensitized to environmental allergens is called atopy
2. Effector Mechanisms in IgE mediated allergic reactions
3. Non-IgE Mediated Allergic disease
HYPERSENSITIVITY
• When antigens not on infectious agents elicit adaptive immune response=disease conditionà
hypersensitivity reactions known as allergic reactions
– Type I: Immediate type mediated by IgE antibodies with mast cell activation
– Type II: Driven by antigen specific IgG, effector being complement
– Type III: Driven by antigen specific IgG, effector being FcR bearing cells
– Type IV: Driven by cellular effectors including lymphocytes and myeloid cell types
IgE AND IgE-MEDIATED ALLERGIC DISEASES
TYPE I HYPERSENSITIVITY (IMMEDIATE)
An IgE mediated response involves mast cell degranulation
Symptoms vary based on route of entry of agent
, PROPERTY OF HIGHYIELD HUB CO -DO NOT COPY
• Caused by activation of mast cells and basophils by multivalent antigen bridging IgE
bound to their cell surfaces.
• IgE is predominant in tissues where it is tightly bound to mast cells via Fc receptor
SENSITIZATION TO AN INHALED ALLERGEN: DER P1 (HOUSE DUST MITE FECAL PELLET
EXAMPLE OF TYPE 1 HYPERSENSITIVITY
EXAMPLE: DER P1 (house dust mite fecal pellet)
TOPIC
A/1
ALLERGY AND ALLERGIC DISEASES
SUMMARY
CONTENTS
1. IgE and IgE mediated allergic diseases
• Caused by activation of mast cells and basophils by antigen bridging IgE bound to their cell
surfaces
• IgE localized in tissues, bound to mast cells through a receptor
,PROPERTY OF HIGHYIELD HUB CO -DO NOT COPY
• When antigen binds, it cross links the IgE receptors causing release of chemical mediators from
mast cells. This is lead to allergic disease
• A predisposition to become IgE sensitized to environmental allergens is called atopy
2. Effector Mechanisms in IgE mediated allergic reactions
3. Non-IgE Mediated Allergic disease
HYPERSENSITIVITY
• When antigens not on infectious agents elicit adaptive immune response=disease conditionà
hypersensitivity reactions known as allergic reactions
– Type I: Immediate type mediated by IgE antibodies with mast cell activation
– Type II: Driven by antigen specific IgG, effector being complement
– Type III: Driven by antigen specific IgG, effector being FcR bearing cells
– Type IV: Driven by cellular effectors including lymphocytes and myeloid cell types
IgE AND IgE-MEDIATED ALLERGIC DISEASES
TYPE I HYPERSENSITIVITY (IMMEDIATE)
An IgE mediated response involves mast cell degranulation
Symptoms vary based on route of entry of agent
, PROPERTY OF HIGHYIELD HUB CO -DO NOT COPY
• Caused by activation of mast cells and basophils by multivalent antigen bridging IgE
bound to their cell surfaces.
• IgE is predominant in tissues where it is tightly bound to mast cells via Fc receptor
SENSITIZATION TO AN INHALED ALLERGEN: DER P1 (HOUSE DUST MITE FECAL PELLET
EXAMPLE OF TYPE 1 HYPERSENSITIVITY
EXAMPLE: DER P1 (house dust mite fecal pellet)
