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1. The period of endrocrinologic, somatic, and transito- Climacteric phase
ry psychologic changes that occur around the time of
menopause.
2. LMP before age 45 Early menopause
3. LMP after age 54 Late menopause
4. Menopause that occurs before age 40 Primary ovarian insufficien-
cy
5. Persistent difference of 7 days or more in the length Early menopause transition
of consecutive cycles. (stage -2)
6. 60 or more consecutive days of amenorrhea Late menopause transition
(stage -1)
7. Explains why some perimenopausal women have Luteal out of phase event
elevated estrogen level sometimes...In the early (LOOP)
menopause transition, elevated FSH levels are ade-
quate to recruit a second follicle which results in a fol-
licular phase-like rise in estradiol secretion superim-
posed on the mid-to-late luteal phase of the ongoing
ovulatory cycle.
8. Obese women are more likely to have anovulatory Obese women and estradi-
cycles with high estradiol levels. They are also more ol levels during menopause
likely to have lower premenopause yet higher post-
menopause estradiol levels compared with women
of normal weight. (why they are at higher risk of
endometrial cancer)
9.
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These ethnic groups have lower estradiol levels then Chinese and Japanese
white, black and hispanic women. women
10. late menopause stage: 5-8 years after FMP. Somatic stage +2
aging predominates. Increased genitourinary symp-
toms.
11. early post menopause: 2 years after FMP. FSH rises, Stages +1a, +1b, +1c
estradiol decreases. VMS predominate.
12. Endocrine labs after menopause Elevated FSH, LH
13. These hormones work during reproductive years to AMH, inhibin B
not deplete follicle pool too quickly.
14. Menstrual cycle shortenes, follicular phase com- Phases during menopause
presses, women spend more time in luteal phase.. transition and PMS symp-
meaning more premenstrual symptoms and more toms
frequent menstrual periods.
15. many pitfalls, variable depending on the day of the How to respond if a patient
cycle you draw the lab, normal or low FSH is not requests FSH lab?
helpful.
16. AMH The potentially superior
marker of menopause, a
lab.
17. Adrenal androgens: precursor hromones produced DHEA (dehydroepiandros-
by the adrenal gland that are enzymatically converted terone)
to active androgens or estrogens in peripheral tis-
sues.
18. Vagina, vulva, urethra, trigone of the bladder
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Location of estrogen recep-
tors
19. maintain blood flow, the collagen, and HA within the Effects of estrogen on tis-
epithelial surfaces. Supports microbiome and pro- sue
tects tissue from pathogens.
20. Thinning, loss of elasticity, loss or absence or rugae. Vaginal changes with
menopause
21. vagina narrows, urethra moves closer to the introitus. Vagina and urethra in
menopause
22. Vaginal estrogen and urinary incontinence: what type Stress urinary incontinence
does it help with?
23. Minoxidil, spironolactone, finasteride, estrogen ther- Treatment for FPHL
apy
24. -3b: menstrual cycles normal, FSH normal, AMH low, Late reporoductive years
AFC low, inhibin low. -3b and -3a. What happens
with menstrual cycles, FSH,
-3a: subtle menstrual changes, variable FSH, AMH AMH, AFC, inhibin?
low, AFC low, inhibin low.
25. Cycle day #3. Elevated estradiol can suppress FSH When it is appropriate to
giving a falsely normal FSH level. check an FSH during the cy-
cle if you check it? and why?
26. produced by granulosa cells AMH
produced by...
used to test damage to ovarian follicle reserve. If used to test...
AMH is low, the woman has a low ovarian reserve. Is it a screening tool for fer-