Final Exam 2 Nu 606 Questions and All Correct Answers .

Histamine - Answer mast cell granules; immediate vasodilation and increased capillary permeability to form exudate Chemotactic factors - Answer mast cell granules; attract neutrophils to site Platelet-activating factor - Answer cell membranes of platelets; activate neutrophils; platelet aggregation Cytokines(interleukins, lymphokines) - Answer t-lymphocytes, macrophages; increase plasma proteins, ESR induce fever, chemotaxis, leukocytosis Leukotrienes - Answer synthesis from arachidonic acid in mast cells; later response: vasodilation and increased capillary permeability, chemotaxis Prostaglandins - Answer synthesis from arachidonic acid in mast cells; vasodilation, increased capillary permeability, pain, fever potentiate histamine effect Kinins (bradykinin) - Answer activation of plasma protein; vasodilation and increased capillary permeability, pain, chemotaxis Complement system - Answer activation of plasma protein cascade; vasodilation and increased capillary permeability, chemotaxis, increased histamine release Type 1 hypersensitivity - Answer IgE bound to mast cells; release histamine and chemical mediators; immediate inflammation and puritis Type 1 hypersensitivity example - Answer hay fever; anaphylaxis Type 2 hypersensitivity - Answer IgG or IgM reacts with antigen on cell-complement activated; cell lysis or phagocytosis Type 2 hypersensitivity example - Answer ABO blood incompatibility Type 3 hypersensitivity - Answer Antigen-antibody complex deposits in tissue; complement activated; inflammation, vasculitis