Test Bank for Genetics and Genomics in Nursing and Health Care, 2nd Edition (Beery, Workman, Eggert)

TEST BANK
Genetics and Genomics in Nursing and Health Care


Theresa A. Beery, M. Linda Workman, and Julia A. Eggert

2nd Edition




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,Table of Contents
H H




ChapterH01HDNAHStructureHandHFunction 1
ChapterH02HProteinHSynthesis 9
ChapterH03HGeneticHInfluenceHonHCellHDivision,HDifferentiation,HandHGametogenesis 19
ChapterH04HPatternsHofHInheritance 29
ChapterH05HEpigeneticHInfluencesHonHGeneHExpression 43
ChapterH06HAutosomalHInheritanceHandHDisorders 47
ChapterH07HSexHChromosomeHandHMitochondrialHInheritanceHandHDisorders 55
ChapterH08HFamilyHHistoryHandHPedigreeHConstruction 61
ChapterH09HCongenitalHAnomalies,HBasicHDysmorphology,HandHGeneticHAssessment 68
ChapterH10HEnzymeHandHCollagenHDisorders 74
ChapterH11HCommonHChildhood-OnsetHGeneticHDisorders 84
ChapterH12HCommonHAdult-OnsetHDisorders 95
ChapterH13HCardiovascularHDisorders 103
ChapterH14HTheHGeneticsHofHCancer 110
ChapterH15HGeneticHContributionsHtoHPsychiatricHandHBehavioralHDisorders 119
ChapterH16HGeneticHandHGenomicHTesting 124
ChapterH17HAssessingHGenomicHVariationHinHDrugHResponse 129
ChapterH18HHealthHProfessionalsHandHGenomicHCare 135
ChapterH19HFinancial,HEthical,HLegal,HandHSocialHConsiderations 140
ChapterH20HGeneticHandHGenomicHVariation 144




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HGeneticsHandHGenomicsHinHNursingHandHHealthHCare,H2ndHEditionH(Beery,H2019)

Chapter1: DNA Structure and Function


MULTIPLEHCHOICE

1. InHwhichHbodyHorHcellHareaHareHmostHgenesHinHhumansHlocated?
a. Nucleus
b. Mitochondrion
c. Cytoplasm
d. PlasmaHmembrane
ANS:H H A
MostHgenesHareHpartHofHtheHDNAHlocatedHinHtheHnucleusHofHbodyHcells.HOnlyHaHfewHgenesHareHl
ocatedHinHaHcell’sHmitochondrionHorHmitochondria.HThereHareHnoHgenesHorHDNAHinHeitherHtheHc
ytoplasmHorHtheHplasmaHmembranesHofHanyHcell.

2. WhichHconditionHorHstatementHexemplifiesHtheHconceptHofHgenomicsHratherHthanHgenetics?
a. TheHgeneHforHinsulinHisHlocatedHonHchromosomeH11HinHallHpeople.
b. ExpressionHofHanyHsingleHgeneHisHdependentHonHinheritingHtwoHalleles.
c. Sex-linkedHrecessiveHdisordersHaffectHmalesHmoreHoftenHthanHfemales.
d. OneHalleleHforHeachHgeneHisHinheritedHfromHtheHmother,HandHoneHisHinheritedHfromHt
heHfather.
ANS:H H A
GeneticsHisHtheHstudyHofHtheHgeneralHmechanismsHofHheredityHandHtheHvariationHofHinheritedH
traits.HGenomicsHisHtheHstudyHofHtheHfunctionHofHallHtheHnucleotideHsequencesHpresentHwithinH
theHentireHgenomeHofHaHs p e c i e s , Wi nWcW
l u.d iTn B
g HS
geMn.
esWiS
nHDNAHcodingHregionsHandHDNAHnoncodin
g
regions.HSelectionsHB,HC,HandHDHallHreferHtoHmechanismsHofHheredity.HOnlyHselectionHAHrefers
toHtheHfunctionHofHaHspecificHnucleotideHsequence.

3. WhatHisHtheHpurposeHofHphosphorousHinHaHDNAHstrand?
a. LinkingHtheHnucleotidesHintoHaHstrand
b. HoldingHcomplementaryHstrandsHtogether
c. EnsuringHthatHaHpurineHisHalwaysHpairedHwithHaHpyrimidine
d. PreventingHtheHseparationHofHdouble-strandedHDNAHintoHsingle-strandedHDNA
ANS:H H A
EachHnucleosideHbecomesHaHcompleteHnucleotideHwhenHaHphosphateHgroupHisHattached.HTheH
phosphatesHhaveHmultipleHbindingHsites,HandHeachHoneHcanHlinkHtoHtwoHnucleotides.HTheseHli
nkagesHallowHtheHnucleotidesHtoHbeHconnectedHwhenHplacedHintoHtheHDNAHstrand.HTheHnucl
eotidesHwithinHeachHstrandHareHheldHinHpositionHbyHtheHlinkedHphosphateHgroups,HwhichHactHl
ikeHtheHstringHholdingHaHstrandHofHbeadsHtogether,HformingHaHnecklace.

4. WhatHisHtheHtermHusedHtoHdefineHalternativeHformsHofHaHgeneHthatHmayHresultHinHdiffere
ntHexpressionHofHtheHtraitHcodedHforHbyHthatHgene?
a. Alleles
b. Bases
c. Centromeres
d. Diploids
HANS:H A



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HGeneticsHandHGenomicsHinHNursingHandHHealthHCare,H2ndHEditionH(Beery,H2019)

ForHeachHsingleHgene,HtwoHalternativeHformsHofHthatHgene,HknownHasHalleles,HtogetherHcontrol
HhowHthatHgeneHisHexpressed.HTheHallelesHmayHbeHidenticalHinHtheirHsequenceHbutHdoHnotHhave

HtoHbe.HWhenHaHdominantHalleleHisHpairedHwithHaHrecessiveHallele,HonlyHtheHdominantHalleleHis

Hexpressed,HandHtheHrecessiveHalleleHisHsilent.HWhenHaHdominantHalleleHisHpairedHwithHanothe

rHdominantHallele,HtheyHareHbothHexpressedH(usuallyHequally).HRecessiveHallelesHareHonlyHexp
ressedHwhenHtheyHareHhomozygous.HBasesHareHtheHessentialHpartHofHaHnucleotide,HofHwhichHt
hereHareHmanyHwithinHanyHgeneHregion.HCentromeresHareHtheHpinched-
inHpartHofHaHchromosomeHbetweenHtheHpHarmsHandHtheHqHarms.HTheHtermHdiploidHrefersHtoHth
eHnormalHnumberHofHchromosomeHpairsHwithinHaHcell.HItHisHanHadjective,HnotHaHnoun.HTheref
ore,HtheHpluralHdiploidsHdoesHnotHexist.

5. WhatHpercentageHofHbasesHinHaHstretchHofHdouble-strandedHDNAHthatHcontainsH30%Hguanine
(G)HbasesHwouldHbeHadenineH(A)?
a. 70%
b. 60%
c. 30%
d. 20%
ANS:H H D
BecauseHofHcomplementaryHpairing,HifH30%HofHtheHbasesHareHguanineH(G),HwhichHalwaysHpairsH
withHcytosineHC,HtheseHtwoHbasesHaccountHforH60%HofHtheHtotalHbasesHinHthisHstretch.HTheHrema
iningHbasesHmakeHupH40%HofHtheHtotal.HThisH40%HisHcomposedHofHequalHpercentagesHofHthymin
eH(T)HandHadenineH(A).

6. WhatHisHtheHtermHusedHtoHdescribeHtheHorganizedHpictureHofHtheHpairedHchromosomesHwithin
HaHcellHusedHtoHdetermineHwhetherHchromosomeHnumbers,Hstructures,HandHbandingHpatternsH

are
normal? WWW.TBSM.WS
a. Pedigree
b. Phenotype
c. Karyotype
d. Autotype
ANS:H H C
AHkaryotypeHisHaHpictureHofHanHorganizedHarrangementHofHallHofHtheHchromosomesHwithinHon
eHcellHduringHtheHmetaphaseHsectionHofHmitosis.HTheHchromosomesHareHpairedHandHthenHarran
gedHbyHnumberHaccordingHtoHsizeHandHcentromereHposition.HTheHbandingHpatternHofHeachHpai
rHisHanalyzedHtoHdetermineHwhetherHareasHhaveHbeenHdeleted,Hexpanded,HorHtranslocated.HAHp
edigreeHalsoHisHaHpicture,HbutHitHillustratesHseveralHgenerationsHofHaHfamilyHhistory.
PhenotypesHareHobservableHtraits.HAutotypeHisHnotHaHgeneticHterm.

7. WhatHwouldHbeHtheHsequenceHofHDNAHthatHisHcomplementaryHtoHaHDNAHsectionHwithHtheHba
seHsequenceHofHGGTCAATCCTTAG?
a. GATTCCTAACTGG
b. TTGACCGAAGGCT
c. AACTGGCTTCCGA
d. CCAGTTAGGAATC
HANS:H D




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