APHON Overview Exam Questions and
Answers (Most Recent Version, Complete
Study Material)
biotherapy - Correct Answers ✅modality of tx: agents that
resemble body's own defense and surveillance systems. can
augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects
typically hypersensitivity rx
immune surveillance - Correct Answers ✅tumor cells
express abnormal tumor antigens on surface that can be
recognized/destroyed by immune system
natural killer cells - Correct Answers ✅lymphocyte that
recognizes/kills malignant cells
cytotoxic t cells - Correct Answers ✅recognize tumor-
assosiated antigens and kills cells
interferons - Correct Answers ✅multiple moa's & produced
w/ recombinant dna.
protein capable of protecting other cells from viral infections
by interfering w/ viral replication.
family of glycoproteins include: antiviral, antiproliferative,
potent immunomodulatory effects
,APHON Overview Exam Questions and
Answers (Most Recent Version, Complete
Study Material)
cytokines - Correct Answers ✅products of immune cells to
enhance cytotoxic activity of cells and increase immune
response
alpha-interferon - Correct Answers ✅leukocyte-derived. tx:
hairy cell leukemia, melanoma, chronic myeloid leukemia,
follicular lymphoma, multiple myeloma, cutaneous t-cell
lymphoma
beta-interferon - Correct Answers ✅fibroblast-derived. tx
MS
gamma-interferon - Correct Answers ✅t-lymphocyte
derived. tx chronic granulomatus disease
interleukin-2 - Correct Answers ✅produced by t-helper
cells & stimulate growth/maturation of t-cell subsets,
cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
retinoids - Correct Answers ✅immunomodulators that
facilitate differentiation & suppress proliferation of cancer
cells
,APHON Overview Exam Questions and
Answers (Most Recent Version, Complete
Study Material)
all-trans retinoic acid (atra) - Correct Answers ✅tx: aml,
aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid
resolution of coagulopathy r/t tx.
isotretinoin (accutane) - Correct Answers ✅retinoid tx
neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC.
male/female pt must register iPledge (fetal exposure). can
also affect hearing & vision
antibodies - Correct Answers ✅proteins produced by b-
lymphocytes. part of humoral immunity of adaptive system.
includes immunoglobulins (igG, igA, igM, igE, igD)
murine - Correct Answers ✅mouse-derived MoAbs. pt
develops human antimouse antibodies creating high risk of
hypersensitivity rx
end in -momab
Monoclonal antibodies - Correct Answers ✅very specific.
directed against single antigenic determinant on cell surface
causing antibody-dependent cellular toxicity, direct cell
death, elimination of antigen/target cell that expresses the
antigen
, APHON Overview Exam Questions and
Answers (Most Recent Version, Complete
Study Material)
low toxicity
-ximab - Correct Answers ✅moab combo of human &
mouse antibodies
-zumab - Correct Answers ✅moab humanized, small part
of mouse antibody fused w/ human antibody
-umab - Correct Answers ✅fully humanized moabs
chimeric moab - Correct Answers ✅murine variable &
human constant coupled using recombinant dna
purpose of moabs - Correct Answers ✅attach low-dose
radioisotopes to image residual disease. target chemo,
radiation, biotherapy to tumor
purge autologous bone marrow of cancer cells before
transplant
selectively remove t cells responsible for gvhd from marrow
prior to allogenic transplant
efficacy increased w/ chemo or radioactive substances
Answers (Most Recent Version, Complete
Study Material)
biotherapy - Correct Answers ✅modality of tx: agents that
resemble body's own defense and surveillance systems. can
augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects
typically hypersensitivity rx
immune surveillance - Correct Answers ✅tumor cells
express abnormal tumor antigens on surface that can be
recognized/destroyed by immune system
natural killer cells - Correct Answers ✅lymphocyte that
recognizes/kills malignant cells
cytotoxic t cells - Correct Answers ✅recognize tumor-
assosiated antigens and kills cells
interferons - Correct Answers ✅multiple moa's & produced
w/ recombinant dna.
protein capable of protecting other cells from viral infections
by interfering w/ viral replication.
family of glycoproteins include: antiviral, antiproliferative,
potent immunomodulatory effects
,APHON Overview Exam Questions and
Answers (Most Recent Version, Complete
Study Material)
cytokines - Correct Answers ✅products of immune cells to
enhance cytotoxic activity of cells and increase immune
response
alpha-interferon - Correct Answers ✅leukocyte-derived. tx:
hairy cell leukemia, melanoma, chronic myeloid leukemia,
follicular lymphoma, multiple myeloma, cutaneous t-cell
lymphoma
beta-interferon - Correct Answers ✅fibroblast-derived. tx
MS
gamma-interferon - Correct Answers ✅t-lymphocyte
derived. tx chronic granulomatus disease
interleukin-2 - Correct Answers ✅produced by t-helper
cells & stimulate growth/maturation of t-cell subsets,
cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
retinoids - Correct Answers ✅immunomodulators that
facilitate differentiation & suppress proliferation of cancer
cells
,APHON Overview Exam Questions and
Answers (Most Recent Version, Complete
Study Material)
all-trans retinoic acid (atra) - Correct Answers ✅tx: aml,
aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid
resolution of coagulopathy r/t tx.
isotretinoin (accutane) - Correct Answers ✅retinoid tx
neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC.
male/female pt must register iPledge (fetal exposure). can
also affect hearing & vision
antibodies - Correct Answers ✅proteins produced by b-
lymphocytes. part of humoral immunity of adaptive system.
includes immunoglobulins (igG, igA, igM, igE, igD)
murine - Correct Answers ✅mouse-derived MoAbs. pt
develops human antimouse antibodies creating high risk of
hypersensitivity rx
end in -momab
Monoclonal antibodies - Correct Answers ✅very specific.
directed against single antigenic determinant on cell surface
causing antibody-dependent cellular toxicity, direct cell
death, elimination of antigen/target cell that expresses the
antigen
, APHON Overview Exam Questions and
Answers (Most Recent Version, Complete
Study Material)
low toxicity
-ximab - Correct Answers ✅moab combo of human &
mouse antibodies
-zumab - Correct Answers ✅moab humanized, small part
of mouse antibody fused w/ human antibody
-umab - Correct Answers ✅fully humanized moabs
chimeric moab - Correct Answers ✅murine variable &
human constant coupled using recombinant dna
purpose of moabs - Correct Answers ✅attach low-dose
radioisotopes to image residual disease. target chemo,
radiation, biotherapy to tumor
purge autologous bone marrow of cancer cells before
transplant
selectively remove t cells responsible for gvhd from marrow
prior to allogenic transplant
efficacy increased w/ chemo or radioactive substances
