GMS 6552 Comprehensive Review Questions with Solutions.

GMS 6552 Comprehensive Review Questions with
Solutions




G-protein coupled receptors - correct answers ✔️✔️Which type of receptor most often utilizes second-
messenger systems in its signaling?



Kinase-linked receptors

Channel-linked receptors

Nuclear receptors

G-protein coupled receptors



Nuclear receptors - correct answers ✔️✔️Assume you have receptor antagonists that are able to stop
receptor signaling immediately. For which type of receptor would it take the longest to see the effects of
your drug at the cellular level?



Kinase-linked receptors

Channel-linked receptors

Nuclear receptors

G-protein coupled receptors

, Nuclear receptors - correct answers ✔️✔️For which type of receptor would having adequate membrane
permeability of an agonist be most critical?



Kinase-linked receptors

Channel-linked receptors

Nuclear receptors

G-protein coupled receptors



N-terminus - correct answers ✔️✔️Is it more likely for a G-protein coupled receptor agonist to bind
near the N- or C- terminus of the receptor?



N-terminus

C-terminus



GDP - correct answers ✔️✔️Is it more likely to find a GPCR bound to a G-protein that is also bound to
GTP or GDP?



GTP

GDP



STAT - correct answers ✔️✔️Which protein ultimately is translocated from the cytoplasm to the nucleus
as a result of JAK signaling?



JAK

GRB2

SH2

PI3K

STAT