GMS 6552 Revision Paper with Accurate Answers
- correct answers ✔️✔️MODULE 5
a gene that causes or contributes to the development of cancer - correct answers ✔️✔A
️ n oncogene is
defined as
In vivo
In vitro - correct answers ✔️✔️What are the two types of evidence for oncogenic behavior?
Cause cancer when activated in a transgenic animal
Render nontumorigenic cells tumorigenic
Knock down or knock out in tumorigenic cells renders the cells nontumorigenic
Activation/overexpression of the oncogene is strongly correlated with human cancer - correct answers
✔️✔️What are the 4 criteria for In vivo oncogenic behavior
Causes anchorage-independent growth in soft agar (protection from anoikis)
Causes focus formation (loss of contact inhibition)
Renders cells growth factor independent - correct answers ✔️✔️What are the 3 criteria for In vitro
oncogenic behavior
, Ras - correct answers ✔️✔️What is an example of a GTPase that plays a biochemical role in oncogenes.
Raf, Akt, BCR-ABL, Cdk4, Src - correct answers ✔️✔️What is an example of a Protein Kinases that plays a
biochemical role in oncogenes.
PI3-Kinase - correct answers ✔️✔️What is an example of a Lipid Kinases that plays a biochemical role in
oncogenes.
Myc, Fos, Jun, E2F1, .... - correct answers ✔️✔️What is an example of a Transcription factors that plays
a biochemical role in oncogenes.
BCL2 - correct answers ✔️✔️What is an example of a Binding and inactivating apoptotic proteins that
plays a biochemical role in oncogenes.
Cyclins A, E, and D - correct answers ✔️✔️What is an example of a Protein Kinase Regulatory Subunits
that plays a biochemical role in oncogenes.
ß-Catenin, YAP, TAZ - correct answers ✔️✔️What is an example of a Transcriptional coactivators that
plays a biochemical role in oncogenes.
1. Mutation of genes to make it overactive.
2. Amplification of a normal gene
3. Chromosomal Rearrangement
4. Promoter/enhancer insertion
5. Hypomethylation of oncogene - correct answers ✔️✔F️ ive Ways to Activate Oncogenes
Philadelphia chromosome. balanced reciprocal translocation t(9:22) in myeloid cells. Fuses 5' end of BCR
gene (chr.22) to the coding region of oncogene ABL
- correct answers ✔️✔️MODULE 5
a gene that causes or contributes to the development of cancer - correct answers ✔️✔A
️ n oncogene is
defined as
In vivo
In vitro - correct answers ✔️✔️What are the two types of evidence for oncogenic behavior?
Cause cancer when activated in a transgenic animal
Render nontumorigenic cells tumorigenic
Knock down or knock out in tumorigenic cells renders the cells nontumorigenic
Activation/overexpression of the oncogene is strongly correlated with human cancer - correct answers
✔️✔️What are the 4 criteria for In vivo oncogenic behavior
Causes anchorage-independent growth in soft agar (protection from anoikis)
Causes focus formation (loss of contact inhibition)
Renders cells growth factor independent - correct answers ✔️✔️What are the 3 criteria for In vitro
oncogenic behavior
, Ras - correct answers ✔️✔️What is an example of a GTPase that plays a biochemical role in oncogenes.
Raf, Akt, BCR-ABL, Cdk4, Src - correct answers ✔️✔️What is an example of a Protein Kinases that plays a
biochemical role in oncogenes.
PI3-Kinase - correct answers ✔️✔️What is an example of a Lipid Kinases that plays a biochemical role in
oncogenes.
Myc, Fos, Jun, E2F1, .... - correct answers ✔️✔️What is an example of a Transcription factors that plays
a biochemical role in oncogenes.
BCL2 - correct answers ✔️✔️What is an example of a Binding and inactivating apoptotic proteins that
plays a biochemical role in oncogenes.
Cyclins A, E, and D - correct answers ✔️✔️What is an example of a Protein Kinase Regulatory Subunits
that plays a biochemical role in oncogenes.
ß-Catenin, YAP, TAZ - correct answers ✔️✔️What is an example of a Transcriptional coactivators that
plays a biochemical role in oncogenes.
1. Mutation of genes to make it overactive.
2. Amplification of a normal gene
3. Chromosomal Rearrangement
4. Promoter/enhancer insertion
5. Hypomethylation of oncogene - correct answers ✔️✔F️ ive Ways to Activate Oncogenes
Philadelphia chromosome. balanced reciprocal translocation t(9:22) in myeloid cells. Fuses 5' end of BCR
gene (chr.22) to the coding region of oncogene ABL
