CHEMOTHERAPY BIOTHERAPY
CERTIFICATION QUESTIONS AND
ANSWERS (GRADED A+)
Resources -ANSWER✔✔nccn.org
cancer.org
LESSON 1: Cell cycle -ANSWER✔✔g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
mitosis -ANSWER✔✔4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
apoptosis -ANSWER✔✔programmed cell death
hematopoiesis -ANSWER✔✔formation of blood cells & how cells differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
Principles of Biotherapy: p51-95 immunology -ANSWER✔✔-defense against
foreign organisms, homeostasis (destroy aged cells), surveillance
immune responses -ANSWER✔✔innate: primary line of defense, non specific, no
memory
,adaptive: secondary line of defence with specific memry
cytokines -ANSWER✔✔-effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing
comunication between cells of the immune system
-regular antiboddy production and function of b cells
vaccines for cancer prevention -ANSWER✔✔-hep B prevents hepatitis and
hepatocellular carcinoma
-hpv vaccine
filgrastim aka neupogen -ANSWER✔✔SC or IV to derease infection in patients
with neutropenic fever associated with myelosuppressive anticancer treatments for
nonmyeloid malignancies
tbo-filgramstim/ pegfilgrastim -ANSWER✔✔reduce duration of neutroenia in
patients with non myeloid malignancies
palifermin -ANSWER✔✔IV to dec incidence of oral mucositis in patients with
hem malignanies before BMT
sargramostim -ANSWER✔✔aka leukine - patients with AML following chemo to
shorten neutrophil recovery and reduce incidence of infection
IFN gamma -ANSWER✔✔reduce frequency and severity o infections related to
granulomatous disease
, aldeleukin -ANSWER✔✔treat renal cell carcinoma and metastatic melanoma
oprevelkin -ANSWER✔✔prevent severe thrombocytopenia and refuce need for
platelet transfusions in patients with nonmyeloid malig
plerixafor -ANSWER✔✔with filgrastim to mobilize hematopoeitc stem cells for
collection from peripheral blood of patients
sipuleucel -ANSWER✔✔castrate resistant prostate cancer
rituximab -ANSWER✔✔rituxan- treatment of relapsed or refractory low grade
follicular b cell NHL_ first line traetment in combo with chemo in patients with
response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia, rigors,
dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each infusion
immune system -ANSWER✔✔1st line: skin , ucous membrane, gut flora
second line: phagocytes:
3rd line antibodies, t and b cells
malignant tumor (cancer) -ANSWER✔✔cell strcuture different from parent tissue,
cell division uncontrolled, loosely adherent, invade neighboring tissue, establish
blood vessels
CERTIFICATION QUESTIONS AND
ANSWERS (GRADED A+)
Resources -ANSWER✔✔nccn.org
cancer.org
LESSON 1: Cell cycle -ANSWER✔✔g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
mitosis -ANSWER✔✔4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
apoptosis -ANSWER✔✔programmed cell death
hematopoiesis -ANSWER✔✔formation of blood cells & how cells differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
Principles of Biotherapy: p51-95 immunology -ANSWER✔✔-defense against
foreign organisms, homeostasis (destroy aged cells), surveillance
immune responses -ANSWER✔✔innate: primary line of defense, non specific, no
memory
,adaptive: secondary line of defence with specific memry
cytokines -ANSWER✔✔-effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing
comunication between cells of the immune system
-regular antiboddy production and function of b cells
vaccines for cancer prevention -ANSWER✔✔-hep B prevents hepatitis and
hepatocellular carcinoma
-hpv vaccine
filgrastim aka neupogen -ANSWER✔✔SC or IV to derease infection in patients
with neutropenic fever associated with myelosuppressive anticancer treatments for
nonmyeloid malignancies
tbo-filgramstim/ pegfilgrastim -ANSWER✔✔reduce duration of neutroenia in
patients with non myeloid malignancies
palifermin -ANSWER✔✔IV to dec incidence of oral mucositis in patients with
hem malignanies before BMT
sargramostim -ANSWER✔✔aka leukine - patients with AML following chemo to
shorten neutrophil recovery and reduce incidence of infection
IFN gamma -ANSWER✔✔reduce frequency and severity o infections related to
granulomatous disease
, aldeleukin -ANSWER✔✔treat renal cell carcinoma and metastatic melanoma
oprevelkin -ANSWER✔✔prevent severe thrombocytopenia and refuce need for
platelet transfusions in patients with nonmyeloid malig
plerixafor -ANSWER✔✔with filgrastim to mobilize hematopoeitc stem cells for
collection from peripheral blood of patients
sipuleucel -ANSWER✔✔castrate resistant prostate cancer
rituximab -ANSWER✔✔rituxan- treatment of relapsed or refractory low grade
follicular b cell NHL_ first line traetment in combo with chemo in patients with
response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia, rigors,
dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each infusion
immune system -ANSWER✔✔1st line: skin , ucous membrane, gut flora
second line: phagocytes:
3rd line antibodies, t and b cells
malignant tumor (cancer) -ANSWER✔✔cell strcuture different from parent tissue,
cell division uncontrolled, loosely adherent, invade neighboring tissue, establish
blood vessels
