Orthopedics - Rheumatologic Conditions Part 2
1. Who is rheumatoid arthritis MC in?: - MC in 4-5th decade for women & 6-8th decade for men
- MC in women > men
2. Describe the onset of rheumatoid arthritis?: Insidious onset
- morning stiffness and pain in affected joints for MORE than 30 minutes-hours
- symmetric swelling of multiple joints
- stiffness may recur after daytime activity and become worse after strenuous activity
3. Which joints are usually affected by rheumatoid arthritis?: - symmetric polyarthritis with
predilection for small joints (MCP, MTP, PIP finger joints, wrists, knees, ankles) of the hands and feet
- may also affect cervical spine
4. What can advanced RA begin to affect?: C1-C2 subluxation, leading to myelopathy
5. What are radiographic findings of rheumatoid arthritis?: - juxta-articular osteoporosis
- joint erosions
- joint space narrowing
6. What are extra-articular manifestations of rheumatoid arthritis?: - subcutaneous
,nodules
- interstitial lung disease
- pleural effusion
- pericarditis
- splenomegaly with leukopenia
- vasculitis
7. What type of antibodies are present with rheumatoid arthritis?: - rheumatoid factor
- cyclic citrullinated peptides (anti-CCP)
- may have antinuclear antibodies (ANA)
8. What is the cause of rheumatoid arthritis?: - unknown
9. What is the best characterized RF for rheumatoid arthritis?: - Inherited HLA DRB1
alleles encoding distinctive five amino-acid sequence ("shared epitope")
10. What are pathologic joint findings of rheumatoid arthritis?: - chronic synovitis with
pannus formation, which erodes cartilage, bone, ligaments, and tendons
11. What will occur if RA is left untreated?: - joint destruction, disability, shortened life span
12. What is a common syndrome with RA?: - Entrapment syndrome of MEDIAN nerve
, 13. What symptom is correlated with the presence of rheumatoid factor in the
serum?: Rheumatoid nodules correlate with "seropositivity"
1. Who is rheumatoid arthritis MC in?: - MC in 4-5th decade for women & 6-8th decade for men
- MC in women > men
2. Describe the onset of rheumatoid arthritis?: Insidious onset
- morning stiffness and pain in affected joints for MORE than 30 minutes-hours
- symmetric swelling of multiple joints
- stiffness may recur after daytime activity and become worse after strenuous activity
3. Which joints are usually affected by rheumatoid arthritis?: - symmetric polyarthritis with
predilection for small joints (MCP, MTP, PIP finger joints, wrists, knees, ankles) of the hands and feet
- may also affect cervical spine
4. What can advanced RA begin to affect?: C1-C2 subluxation, leading to myelopathy
5. What are radiographic findings of rheumatoid arthritis?: - juxta-articular osteoporosis
- joint erosions
- joint space narrowing
6. What are extra-articular manifestations of rheumatoid arthritis?: - subcutaneous
,nodules
- interstitial lung disease
- pleural effusion
- pericarditis
- splenomegaly with leukopenia
- vasculitis
7. What type of antibodies are present with rheumatoid arthritis?: - rheumatoid factor
- cyclic citrullinated peptides (anti-CCP)
- may have antinuclear antibodies (ANA)
8. What is the cause of rheumatoid arthritis?: - unknown
9. What is the best characterized RF for rheumatoid arthritis?: - Inherited HLA DRB1
alleles encoding distinctive five amino-acid sequence ("shared epitope")
10. What are pathologic joint findings of rheumatoid arthritis?: - chronic synovitis with
pannus formation, which erodes cartilage, bone, ligaments, and tendons
11. What will occur if RA is left untreated?: - joint destruction, disability, shortened life span
12. What is a common syndrome with RA?: - Entrapment syndrome of MEDIAN nerve
, 13. What symptom is correlated with the presence of rheumatoid factor in the
serum?: Rheumatoid nodules correlate with "seropositivity"
