Walden 6630 Psychopharmacology Midterm
Study Guide questions and answers
2024\2025 A+ Grade
Serotonin regulates
- correct answer Mood, emotion, feeding, and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of serotonin to
increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors
- correct answer SSRIs
First line therapy for MDD due to milder side effect profiles
- correct answer SSRIs
Six Common SSRIs
- correct answer citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine
Onset of therapeutic benefit from SSRIs
- correct answer 4-6 weeks
In addition to MDD, SSRIs also treat
- correct answer Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia)
Five Common side effects of SSRIs include
- correct answer Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old
- correct answer suicidal ideation
,Life threatening adverse effect of SSRIs, especially when used in combination with other serotonergic
drugs (SNRIs, TCAs, MAOIs, etc.)
- correct answer Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous system
- correct answer Serotonin Syndrome
Seven symptoms of Serotonin Syndrome
- correct answer Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia
The treatment for serotonin syndrome
- correct answer Cyproheptadine (5-HT2 receptor antagonist)
Cyproheptadine treats serotonin syndrome by
- correct answer blocking 5-HT2 receptors (serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include
- correct answer Irritability, headaches, and insomnia
Medicine specific side effect of citalopram
- correct answer Prolonged QT interval (normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects
- correct answer Paroxetine
All SSRIs but paroxetine (D) are pregnancy category
- correct answer C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes
- correct answer fluoxetine, fluvoxamine, and paroxetine
Five common SNRIs include
- correct answer duloxetine, venlafaxine, desvenlafaxine, milnacipran, levomilnacipran
, This antidepressant class of medications works by binding to presynaptic SERT and NET to inhibit them
from reuptake of serotonin and norepinephrine to increase their levels in the synaptic cleft
- correct answer SNRIs
In addition to MDD SNRIs treat
- correct answer Anxiety and neuropathic pain (peripheral neuropathy)
Medication specific indications of duloxetine:
- correct answer urinary incontinence and Fibromyalgia
Medication specific indications of venlafaxine:
- correct answer social anxiety, panic disorders, PTSD, OCD, postmenopausal hot flashes
Six common side effects of SNRIs include:
- correct answer Insomnia, nausea, sexual dysfunction, hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old:
- correct answer suicidal ideation
Life threatening adverse effect of SNRIs, especially when used in combination with other serotonergic
drugs:
- correct answer Serotonin Syndrome
This SNRI is an inhibitor of Cytochrome P450 enzymes:
- correct answer venlafaxine
This SNRI is hepatotoxic:
- correct answer duloxetine
MAOIs increase the levels of:
- correct answer Serotonin, Norepinephrine, and Dopamine
Study Guide questions and answers
2024\2025 A+ Grade
Serotonin regulates
- correct answer Mood, emotion, feeding, and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of serotonin to
increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors
- correct answer SSRIs
First line therapy for MDD due to milder side effect profiles
- correct answer SSRIs
Six Common SSRIs
- correct answer citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine
Onset of therapeutic benefit from SSRIs
- correct answer 4-6 weeks
In addition to MDD, SSRIs also treat
- correct answer Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia)
Five Common side effects of SSRIs include
- correct answer Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old
- correct answer suicidal ideation
,Life threatening adverse effect of SSRIs, especially when used in combination with other serotonergic
drugs (SNRIs, TCAs, MAOIs, etc.)
- correct answer Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous system
- correct answer Serotonin Syndrome
Seven symptoms of Serotonin Syndrome
- correct answer Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia
The treatment for serotonin syndrome
- correct answer Cyproheptadine (5-HT2 receptor antagonist)
Cyproheptadine treats serotonin syndrome by
- correct answer blocking 5-HT2 receptors (serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include
- correct answer Irritability, headaches, and insomnia
Medicine specific side effect of citalopram
- correct answer Prolonged QT interval (normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects
- correct answer Paroxetine
All SSRIs but paroxetine (D) are pregnancy category
- correct answer C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes
- correct answer fluoxetine, fluvoxamine, and paroxetine
Five common SNRIs include
- correct answer duloxetine, venlafaxine, desvenlafaxine, milnacipran, levomilnacipran
, This antidepressant class of medications works by binding to presynaptic SERT and NET to inhibit them
from reuptake of serotonin and norepinephrine to increase their levels in the synaptic cleft
- correct answer SNRIs
In addition to MDD SNRIs treat
- correct answer Anxiety and neuropathic pain (peripheral neuropathy)
Medication specific indications of duloxetine:
- correct answer urinary incontinence and Fibromyalgia
Medication specific indications of venlafaxine:
- correct answer social anxiety, panic disorders, PTSD, OCD, postmenopausal hot flashes
Six common side effects of SNRIs include:
- correct answer Insomnia, nausea, sexual dysfunction, hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old:
- correct answer suicidal ideation
Life threatening adverse effect of SNRIs, especially when used in combination with other serotonergic
drugs:
- correct answer Serotonin Syndrome
This SNRI is an inhibitor of Cytochrome P450 enzymes:
- correct answer venlafaxine
This SNRI is hepatotoxic:
- correct answer duloxetine
MAOIs increase the levels of:
- correct answer Serotonin, Norepinephrine, and Dopamine
