PRITE NINJA High Yield 2025 Exam Questions
and Answers
60 yo R-handed M, getng lost, only writes on right half of paper (image of a clock with all numbers
drawn only on R side) L hemi-neglect. Where is the lesion? (10x) - ✅✅RIGHT PARIETAL LOBE
66 yo w/ HTN develops vertgo, diplopia, nausea, vomitng, hiccups, L A7ace numbness, nystagmus,
hoarseness, ataxia of limbs, staggering gait, and tendency to fall to the lef. Dx? (8x) - ✅✅LATERAL
MEDULLARY STROKE
26 yo w/ HA and R-hand clumsiness for weeks. Exam shows difficulty w/ rapid alternatng movements of
hand, overt intenton tremor on finger-to-nose, and mildly dysmetric finger tapping. CNS intact and no
papilledema. Where will damage show on MRI? (5x) - ✅✅CEREBELLUM
78 yo had ischemic stroke that lef him with a residual mild hemiplegia. Pt appeared to be unaware that
there was a problem of weakness on one side of body. When asked to raise the weak arm, the patent
raised his normal arm. When the failure to raise the paralyzed arm was pointed out to pt, he admied
that the arm was slightly weak. He also neglects the side of the body when dressing and grooming. Pt
did not shave one side of his face, had difficulty putng a shirt on when it was turned inside out. Area of
the brain likely affected by stroke? (4x) - ✅✅RIGHT PARIETAL LOBE
Adult neurogenesis happens in which area of the brain? (4x) - ✅✅HIPPOCAMPUS
In addicton, dopaminergic neurons project to nucleus accumbens. Cell bodies of these neurons reside in
which area of the brain? (3x) - ✅✅VENTRAL TEGMENTAL AREA
Where in the brain are circadian rhythms related to sleep behavior set and maintained? (3x) -
✅✅SUPRACHIASMATIC NUCLEUS
Previously pleasant mom becomes profane and irresponsible over 6 months. Most likely a pathology in?
(2x) - ✅✅FRONTAL LOBE
Which structure connects the frontal and temporal lobes? (2x) - ✅✅ARCUATE FASCICULUS
,Rapid onset of right facial weakness, lef limb weakness, diplopia . Dx? (2x) - ✅✅BRAIN STEM
INFARCTION
Orexin made in what part of the brain? (2x) - ✅✅LATERAL HYPOTHALAMIC NUCLEI
Brain area actvated by subliminal presentatons of emotonal faces (2x) - ✅✅AMYGDALA
Where does histamine synthesis happen? (2x) - ✅✅HYPOTHALAMUS
Which dopaminergic pathway includes the nucleus accumbens and also mediates addicton and
associated behaviors/reinforcing? (2x) - ✅✅MESOLIMBIC
Neural plastcity is largely mediated through the capacity o rapidly change in number and morphology of
what cell structure? (x2) - ✅✅DENDRITIC SPINES
Neurogenesis in the adult brain is restricted to what hippocampal region? (2x) - ✅✅DENTANTE
GYRUS
What sensaton is transmied through the spinothalamic tract? (2x) - ✅✅PAIN
Which brain region does leptn work at? (2x) - ✅✅HYPOTHALAMUS
Brain region suppressed by oxytocin during emotonal situatons: (2x) - ✅✅AMYGDALA
Cortcotropin-releasing hormone is released from which brain region during stress? (2x) -
✅✅PARAVENTRICULAR NUCLEUS
Wakefulness depends on which brain area? (2x) - ✅✅ASCENDING RETICULAR ACTIVATING SYSTEM
,What forms the neural tube? (2x) - ✅✅ECTODERM
Which brain region is most commonly targeted with rTMS for Major Depressive Disorder/ Unipolar
Depression? (2x) - ✅✅DORSOLATERAL PREFRONTAL CORTEX
What neurodevelopmental process predominantly occurs during adolescence and young adulthood?
(2x) - ✅✅SYNAPTIC PRUNING
Pt receives neck manipulaton, now has dysarthric speech, gait ataxia, numbness right body, neck pain.
Dx? (2x) - ✅✅VERTEBRAL ARTERY DISSECTION
What occurs when the central nervous system responds to an acute cortcal insult? (2x) -
✅✅MICROGLIA PROCESSES RETRACT AND THE CELL BODY ENLARGES
Cortcal synaptc remodeling characteristc of normal adolescence is also believed to be associated w/
what neurobiological change? (2x) - ✅✅PREFERENTIAL LOSS OF EXCITATORY SYNAPSES
Relaxaton state in biofeedback shows a decrease in what physiological measure? (2x) - ✅✅SKIN
CONDUCTANCE
What hormone is synthesized in the arcuate nucleus of the hypothalamus? (2x) - ✅✅NEUROPEPTIDE
Y
How estrogen modulates effects on neuroinflammaton? (2x) - ✅✅DECREASED INFLAMMATORY
CYTOKINES
DA release in what structure represents common final event associated w/ reinforcing effects of opiates,
cocaine, amphetamines, nicotne, PCP, and alcohol? (5x) - ✅✅NUCLEUS ACCUMBENS
In addicton, dopaminergic neurons project to nucleus accumbens. Cell bodies of these neurons reside in
which area of the brain? (3x) - ✅✅VENTRAL TEGMENTAL AREA
, Neurohormone for social bonding (3x) - ✅✅OXYTOCIN
Rate-limitng enzyme in the synthesis of norepinephrine and dopamine: (3x) - ✅✅TYROSINE
HYDROXYLASE
Metabolite of what hormone modulates GABA-A, seen in depression? (3x) - ✅✅PROGESTERONE
What NT is predominantly inhibitory? (3x) - ✅✅GLYCINE
Role of glycine at NMDA receptor (2x) - ✅✅OBLIGATE COAGONIST
Which NT system is the last to mature in the CNS of children and adolescents? (2x) -
✅✅CHOLINERGIC
A compound that increases muscle mass by increasing episodic secreton of GH: (2x) - ✅✅GAMMA
HYDROXYBUTYRATE
Neurochemical that reinforces effects of drugs of abuse acutely (2x) - ✅✅DOPAMINE
Decreased level of what NT is most associated with depressed mood, poor sleep, and poor impulse
control, and affectve aggression? (2x) - ✅✅SEROTONIN
NT that's downregulated in ventral striatum in someone with persistent pain: (2x) - ✅✅DOPAMINE
Pain by neurogenic inflammaton is mediated by what substance? (2x) - ✅✅SUBSTANCE P
There is increased actvity of this substance in MDD regardless of treatment modality: (2x) - ✅✅BDNF
Environmental pollutant found to be a neurotoxin decreases tyrosine hydroxylase. Which types of
neurons will be impaired? (2x) - ✅✅DOPAMINERGIC
and Answers
60 yo R-handed M, getng lost, only writes on right half of paper (image of a clock with all numbers
drawn only on R side) L hemi-neglect. Where is the lesion? (10x) - ✅✅RIGHT PARIETAL LOBE
66 yo w/ HTN develops vertgo, diplopia, nausea, vomitng, hiccups, L A7ace numbness, nystagmus,
hoarseness, ataxia of limbs, staggering gait, and tendency to fall to the lef. Dx? (8x) - ✅✅LATERAL
MEDULLARY STROKE
26 yo w/ HA and R-hand clumsiness for weeks. Exam shows difficulty w/ rapid alternatng movements of
hand, overt intenton tremor on finger-to-nose, and mildly dysmetric finger tapping. CNS intact and no
papilledema. Where will damage show on MRI? (5x) - ✅✅CEREBELLUM
78 yo had ischemic stroke that lef him with a residual mild hemiplegia. Pt appeared to be unaware that
there was a problem of weakness on one side of body. When asked to raise the weak arm, the patent
raised his normal arm. When the failure to raise the paralyzed arm was pointed out to pt, he admied
that the arm was slightly weak. He also neglects the side of the body when dressing and grooming. Pt
did not shave one side of his face, had difficulty putng a shirt on when it was turned inside out. Area of
the brain likely affected by stroke? (4x) - ✅✅RIGHT PARIETAL LOBE
Adult neurogenesis happens in which area of the brain? (4x) - ✅✅HIPPOCAMPUS
In addicton, dopaminergic neurons project to nucleus accumbens. Cell bodies of these neurons reside in
which area of the brain? (3x) - ✅✅VENTRAL TEGMENTAL AREA
Where in the brain are circadian rhythms related to sleep behavior set and maintained? (3x) -
✅✅SUPRACHIASMATIC NUCLEUS
Previously pleasant mom becomes profane and irresponsible over 6 months. Most likely a pathology in?
(2x) - ✅✅FRONTAL LOBE
Which structure connects the frontal and temporal lobes? (2x) - ✅✅ARCUATE FASCICULUS
,Rapid onset of right facial weakness, lef limb weakness, diplopia . Dx? (2x) - ✅✅BRAIN STEM
INFARCTION
Orexin made in what part of the brain? (2x) - ✅✅LATERAL HYPOTHALAMIC NUCLEI
Brain area actvated by subliminal presentatons of emotonal faces (2x) - ✅✅AMYGDALA
Where does histamine synthesis happen? (2x) - ✅✅HYPOTHALAMUS
Which dopaminergic pathway includes the nucleus accumbens and also mediates addicton and
associated behaviors/reinforcing? (2x) - ✅✅MESOLIMBIC
Neural plastcity is largely mediated through the capacity o rapidly change in number and morphology of
what cell structure? (x2) - ✅✅DENDRITIC SPINES
Neurogenesis in the adult brain is restricted to what hippocampal region? (2x) - ✅✅DENTANTE
GYRUS
What sensaton is transmied through the spinothalamic tract? (2x) - ✅✅PAIN
Which brain region does leptn work at? (2x) - ✅✅HYPOTHALAMUS
Brain region suppressed by oxytocin during emotonal situatons: (2x) - ✅✅AMYGDALA
Cortcotropin-releasing hormone is released from which brain region during stress? (2x) -
✅✅PARAVENTRICULAR NUCLEUS
Wakefulness depends on which brain area? (2x) - ✅✅ASCENDING RETICULAR ACTIVATING SYSTEM
,What forms the neural tube? (2x) - ✅✅ECTODERM
Which brain region is most commonly targeted with rTMS for Major Depressive Disorder/ Unipolar
Depression? (2x) - ✅✅DORSOLATERAL PREFRONTAL CORTEX
What neurodevelopmental process predominantly occurs during adolescence and young adulthood?
(2x) - ✅✅SYNAPTIC PRUNING
Pt receives neck manipulaton, now has dysarthric speech, gait ataxia, numbness right body, neck pain.
Dx? (2x) - ✅✅VERTEBRAL ARTERY DISSECTION
What occurs when the central nervous system responds to an acute cortcal insult? (2x) -
✅✅MICROGLIA PROCESSES RETRACT AND THE CELL BODY ENLARGES
Cortcal synaptc remodeling characteristc of normal adolescence is also believed to be associated w/
what neurobiological change? (2x) - ✅✅PREFERENTIAL LOSS OF EXCITATORY SYNAPSES
Relaxaton state in biofeedback shows a decrease in what physiological measure? (2x) - ✅✅SKIN
CONDUCTANCE
What hormone is synthesized in the arcuate nucleus of the hypothalamus? (2x) - ✅✅NEUROPEPTIDE
Y
How estrogen modulates effects on neuroinflammaton? (2x) - ✅✅DECREASED INFLAMMATORY
CYTOKINES
DA release in what structure represents common final event associated w/ reinforcing effects of opiates,
cocaine, amphetamines, nicotne, PCP, and alcohol? (5x) - ✅✅NUCLEUS ACCUMBENS
In addicton, dopaminergic neurons project to nucleus accumbens. Cell bodies of these neurons reside in
which area of the brain? (3x) - ✅✅VENTRAL TEGMENTAL AREA
, Neurohormone for social bonding (3x) - ✅✅OXYTOCIN
Rate-limitng enzyme in the synthesis of norepinephrine and dopamine: (3x) - ✅✅TYROSINE
HYDROXYLASE
Metabolite of what hormone modulates GABA-A, seen in depression? (3x) - ✅✅PROGESTERONE
What NT is predominantly inhibitory? (3x) - ✅✅GLYCINE
Role of glycine at NMDA receptor (2x) - ✅✅OBLIGATE COAGONIST
Which NT system is the last to mature in the CNS of children and adolescents? (2x) -
✅✅CHOLINERGIC
A compound that increases muscle mass by increasing episodic secreton of GH: (2x) - ✅✅GAMMA
HYDROXYBUTYRATE
Neurochemical that reinforces effects of drugs of abuse acutely (2x) - ✅✅DOPAMINE
Decreased level of what NT is most associated with depressed mood, poor sleep, and poor impulse
control, and affectve aggression? (2x) - ✅✅SEROTONIN
NT that's downregulated in ventral striatum in someone with persistent pain: (2x) - ✅✅DOPAMINE
Pain by neurogenic inflammaton is mediated by what substance? (2x) - ✅✅SUBSTANCE P
There is increased actvity of this substance in MDD regardless of treatment modality: (2x) - ✅✅BDNF
Environmental pollutant found to be a neurotoxin decreases tyrosine hydroxylase. Which types of
neurons will be impaired? (2x) - ✅✅DOPAMINERGIC
