Hematology Comprehensive Exam
Questions with Verified Answers
Megaloblastic anemias are commonly due to iron deficiency. - ANSWERSFalse
A differential leukocyte count revealed 225 nucleated RBC's/100 WBC's. The total
leukocyte count was 7,000/µl. What is the corrected total leukocyte count? -
ANSWERS2154
Using the following data, calculate the MCV.
RBC = 5.45 x 10 9 /L; Hgb = 11.0g/dl; Hct= 32.8% - ANSWERS60 pg
All of the following can be found in red blood cells as inclusions except -
ANSWERSAuer rod
This cell with pink cytoplasm pale neutrophilic granules and a dense nucleus with an
indentation less than one half its diameter is called a: - ANSWERSmetamyelocyte
The function of von Willebrand Factor is to - ANSWERScause the adhesion of platelets
to the wall of damaged vessels
Match the test with the purpose of the test. Each answer may be used only once. -
ANSWERS-Plasminogen- measures inactive form of fibrinolysis activator
-Platelet aggregation- measures the ability of platelets to adhere to other platelets
-APTT- screens abnormalities in the intrinsic coagulation pathway
-Thrombin time- evaluates quantitative and qualitative fibrinogen defects
-D-Dimer- detects level of fibrin fragments
Which organ removes erythrocyte inclusions without destroying the cell? -
ANSWERSSpleen
A patient presents with an unspecified coagulopathy. The PT, APTT, and thrombin time
(TT) are all prolonged. Fibrinogen is below normal levels. Adsorbed plasma and aged
serum fail to correct the prolonged times. The clinical laboratory scientist considers
either disseminated intravascular coagulation or advanced liver disease as possible
explanations for the coagulopathy. In the absence of any other relevant clinical
information, the most useful procedure to perform in making the differential diagnosis is
a - ANSWERS
A manual WBC count was performed on an EDTA sample. It was diluted 1:100 and a
total of 75 WBC's were counted in all 9 squares of the hemacytometer. What is the
leukocyte count? - ANSWERS8.3 x 109/L
, The definition of hemostasis is the - ANSWERStermination of bleeding following a
traumatic injury
The test used to determine the erythrocyte response and potential of the bone marrow
is - ANSWERSreticulocyte count
An abnormal APTT and normal PT would be consistent with all of the following factor
deficiencies except factor - ANSWERSX
Hemophilia A is caused by a genetically inherited deficiency of - ANSWERSFactor VIII
A patient has a coagulation workup with the following results:
PT= Normal, APTT = Abnormal, Adsorbed plasma APTT= Corrected, Aged serum
APTT = not corrected.
What is the most probable factor deficiency? - ANSWERSVIII
What findings would be most useful for distinguishing AML from ALL? - ANSWERSlarge
blast cells with prominent nucleoli; Auer rods may be present; positive peroxidase and
Sudan black; negative TdT
Characteristics of chronic leukemias include large numbers of immature cells and long
survival rate - ANSWERSFalse
The most common hemoglobinopathy resulting from an amino acid substitution in the
globin chain is - ANSWERS
The LAP score - ANSWERSis useful in differentiating leukemoid states from leukemia
Lupus anticoagulant is a/an - ANSWERScongenital inhibitor
A Greek immigrant has the following RBC morphology: marked poikylocytosis,
microcytic-hypochromic, target cells, NRBC's, and additional bizarre shaped RBCs.
What is the most likely diagnosis? - ANSWERSiron deficiency anemia
The portion of the semen analysis that must be performed within a half hour of receiving
the specimen in the lab is - ANSWERSmotility
A 60-year old man is told by his doctor to collect three fecal specimens for detection of
occult blood. His hematology results indicate anemia.
The urinalysis is normal and the stool is normal color.
All three fecal specimens are positive for occult blood. What is the most likely reason for
this? - ANSWERSGI bleed
The tourniquet test is primarily a test of the - ANSWERSvascular integrity
Questions with Verified Answers
Megaloblastic anemias are commonly due to iron deficiency. - ANSWERSFalse
A differential leukocyte count revealed 225 nucleated RBC's/100 WBC's. The total
leukocyte count was 7,000/µl. What is the corrected total leukocyte count? -
ANSWERS2154
Using the following data, calculate the MCV.
RBC = 5.45 x 10 9 /L; Hgb = 11.0g/dl; Hct= 32.8% - ANSWERS60 pg
All of the following can be found in red blood cells as inclusions except -
ANSWERSAuer rod
This cell with pink cytoplasm pale neutrophilic granules and a dense nucleus with an
indentation less than one half its diameter is called a: - ANSWERSmetamyelocyte
The function of von Willebrand Factor is to - ANSWERScause the adhesion of platelets
to the wall of damaged vessels
Match the test with the purpose of the test. Each answer may be used only once. -
ANSWERS-Plasminogen- measures inactive form of fibrinolysis activator
-Platelet aggregation- measures the ability of platelets to adhere to other platelets
-APTT- screens abnormalities in the intrinsic coagulation pathway
-Thrombin time- evaluates quantitative and qualitative fibrinogen defects
-D-Dimer- detects level of fibrin fragments
Which organ removes erythrocyte inclusions without destroying the cell? -
ANSWERSSpleen
A patient presents with an unspecified coagulopathy. The PT, APTT, and thrombin time
(TT) are all prolonged. Fibrinogen is below normal levels. Adsorbed plasma and aged
serum fail to correct the prolonged times. The clinical laboratory scientist considers
either disseminated intravascular coagulation or advanced liver disease as possible
explanations for the coagulopathy. In the absence of any other relevant clinical
information, the most useful procedure to perform in making the differential diagnosis is
a - ANSWERS
A manual WBC count was performed on an EDTA sample. It was diluted 1:100 and a
total of 75 WBC's were counted in all 9 squares of the hemacytometer. What is the
leukocyte count? - ANSWERS8.3 x 109/L
, The definition of hemostasis is the - ANSWERStermination of bleeding following a
traumatic injury
The test used to determine the erythrocyte response and potential of the bone marrow
is - ANSWERSreticulocyte count
An abnormal APTT and normal PT would be consistent with all of the following factor
deficiencies except factor - ANSWERSX
Hemophilia A is caused by a genetically inherited deficiency of - ANSWERSFactor VIII
A patient has a coagulation workup with the following results:
PT= Normal, APTT = Abnormal, Adsorbed plasma APTT= Corrected, Aged serum
APTT = not corrected.
What is the most probable factor deficiency? - ANSWERSVIII
What findings would be most useful for distinguishing AML from ALL? - ANSWERSlarge
blast cells with prominent nucleoli; Auer rods may be present; positive peroxidase and
Sudan black; negative TdT
Characteristics of chronic leukemias include large numbers of immature cells and long
survival rate - ANSWERSFalse
The most common hemoglobinopathy resulting from an amino acid substitution in the
globin chain is - ANSWERS
The LAP score - ANSWERSis useful in differentiating leukemoid states from leukemia
Lupus anticoagulant is a/an - ANSWERScongenital inhibitor
A Greek immigrant has the following RBC morphology: marked poikylocytosis,
microcytic-hypochromic, target cells, NRBC's, and additional bizarre shaped RBCs.
What is the most likely diagnosis? - ANSWERSiron deficiency anemia
The portion of the semen analysis that must be performed within a half hour of receiving
the specimen in the lab is - ANSWERSmotility
A 60-year old man is told by his doctor to collect three fecal specimens for detection of
occult blood. His hematology results indicate anemia.
The urinalysis is normal and the stool is normal color.
All three fecal specimens are positive for occult blood. What is the most likely reason for
this? - ANSWERSGI bleed
The tourniquet test is primarily a test of the - ANSWERSvascular integrity
