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Exam (elaborations)

MLS ASCP Exam Questions with Detailed Verified Answers

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MLS ASCP Exam Questions with Detailed Verified Answers

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MLS ASCP
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MLS ASCP

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Uploaded on
October 12, 2025
Number of pages
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Written in
2025/2026
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MLS ASCP Exam Questions with Detailed Verified
Answers



c antigen is most common in blacks and whites; anti-c would be most
common reactive Ans:— Rh antibodies show enhanced reactivity with
enzyme pretreated cells. The M and Fya antigens are cleaved from
enzyme pretreated cells and therefore there would be no reaction
between enzyme pretreated cells and serum containing anti-M or anti-
Fya. The incidence of the c antigen is 80% in whites and 96% in blacks.
The incidence of the E antigen is 29% in whites and 22% in blacks.
Increased reactivity with enzyme pretreated cells and incompatible
results with 8 of 10 donor units is most likely due to anti-c.

Procainamide Ans:— NAPA

loose clusters of small spherical microconidia, positive urease Ans:—
Trichophyton mentagrophytes

BHCG tumor marker Ans:— chorocarcinoma

5HIAA Ans:— carcinoid tumors

Proteus vulgaris vs P. mirabilis indole test Ans:— P. vulgaris is indole
pos. P. mirabilis is indole neg

Hydatid cyst fluid Ans:— used to neutralize Anti-P1 antibody

Antacid overdose Ans:— Check pH

Prolonged PT, PTT, and thrombin after collecting from catheter Ans:—
heparin contamination

mixing study that was performed with a prolonged PTT that couldn't be
corrected Ans:— DRVVT (Dilute Russell Viper Venom Test)

two pt's ran in duplicate (PT and PTT). The PTT seemed to always be
prolonged but PT looked ok Ans:— check the CaCl/phospholipid
reagent delivery

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Patient is on coumadin therapy, what will be affected Ans:— Decreased
protein C

Lot's of stomatocytes Ans:— Liver disease

Burr cells Ans:— Uremia

Picture of target cells with hemoglobin C crystals. The white count was
high on instrument 1, so a second instrument was used with a stronger
lysing agent, and the white count was corrected Ans:— anti-lysing
target cells are what increased the white count? Erythrocytes containing
hemoglobin C do not lyse normally (sickle cell diseases)

A sodium citrate tube was drawn for a HCT on a pt but the hematocrit
was abnormal Ans:— recollect with decreased anticoagulant. high hct
(>55%) causes low plasma so you need less anticoagulant

Question that gives a red blood cells count, HGB, and HCT. I did the rule
of 3 and found that the HGB didn't meet the rule of 3 because it was too
high Ans:— check for lipemia (elevates HGB)

PBS with an elevated reticulocyte count and howell jolly bodies in the
RBC's Ans:— Prussian blue for howell jolly bodies made of iron.
Prussian blue stain, which is not taken up by reticulocytes, is helpful in
differentiating the two.

what is composed of DNA? Ans:— howell jolly bodies

what falsely increases ESR Ans:— vibration, tilting of tube, higher
temps, >1 hr test time, improper mixing of blood, improper dilution

factors decreasing ESR Ans:— Polycythemia, Microcytosis (Hb C),
Sickle cells, spherocytes, Anti-inflammatory medications,
Hypogammaglobulinemia, Hypofibrinogenemia (DIC), High WBC count,
Hyperviscosity

Factors increasing ESR Ans:— Anemia, Macrocytosis, Female gender,
Age >50 years, Obesity, Pregnancy, Hypercholesterolemia, cancer,
multiple myeloma, rouleaux, infections, inflammation

what falsely decreases ESR Ans:— low blood/ room temps, air bubbles,
tests <1 hr, improper mixing of blood, improper dilution

lactic acid collection Ans:— separate from serum and put on ice

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