Systemic Lupus Erythematosus Exam
Questions And Correct Answers
Type III (immune complex) - ANSWER What type of hypersensitivity causes systemic
lupus erythematosus (name and number)?
HLA-DR2 and HLA-DR3 - ANSWER What is the HLA association for SLE?
Immune complexes become trapped in the basement membrane of glomeruli, skin,
joints, and kidney which leads to a type III hypersensitivity response. - ANSWER What is
the mechanism of pathology for SLE?
ds-DNA, phospholipid, leukocytes, and ANA. - ANSWER What antigen(s) are involved in
SLE?
Anti-ds-DNA antibody, anti-ANA antibody, anti-leukocyte antibody, and
anti-phospholipid antibody. - ANSWER What antibodies are involved in SLE?
Photosensitivity, facial rash, and spontaneous abortion. - ANSWER What are the
characteristic features of SLE?
Anti-dsDNA antibody and anti-cardiolipin antibody tests. - ANSWER What investigations
can be used to help identify SLE?
The creation and secretion of antibodies which leads to deposition of antibodies in this
condition is controlled by B-cells. CD20 is expressed in all B-cells except the pro-B-cell
which means that this drug will limit growth of the cells but because it is an antibody it
will cause destruction of the B-cells which in turn causes reduced antibody production
and secretion and reduction in the symptoms of SLE. - ANSWER Some patients with SLE
are prescribed an anti-CD20 antibody. How does this work to treat SLE?
Questions And Correct Answers
Type III (immune complex) - ANSWER What type of hypersensitivity causes systemic
lupus erythematosus (name and number)?
HLA-DR2 and HLA-DR3 - ANSWER What is the HLA association for SLE?
Immune complexes become trapped in the basement membrane of glomeruli, skin,
joints, and kidney which leads to a type III hypersensitivity response. - ANSWER What is
the mechanism of pathology for SLE?
ds-DNA, phospholipid, leukocytes, and ANA. - ANSWER What antigen(s) are involved in
SLE?
Anti-ds-DNA antibody, anti-ANA antibody, anti-leukocyte antibody, and
anti-phospholipid antibody. - ANSWER What antibodies are involved in SLE?
Photosensitivity, facial rash, and spontaneous abortion. - ANSWER What are the
characteristic features of SLE?
Anti-dsDNA antibody and anti-cardiolipin antibody tests. - ANSWER What investigations
can be used to help identify SLE?
The creation and secretion of antibodies which leads to deposition of antibodies in this
condition is controlled by B-cells. CD20 is expressed in all B-cells except the pro-B-cell
which means that this drug will limit growth of the cells but because it is an antibody it
will cause destruction of the B-cells which in turn causes reduced antibody production
and secretion and reduction in the symptoms of SLE. - ANSWER Some patients with SLE
are prescribed an anti-CD20 antibody. How does this work to treat SLE?
