MARYVILLE U. PHARM NURS615 EXAM 3 WITH COMPLETE ANSWER,2025,LATEST UPLOAD....

MARYVILLE U. PHARM NURS615 EXAM 3 COMPLETE QUESTIONS & n n n n n n n n




ANSWERS (100% VERIFIED SOLUTIONS) 2025/2026 UPDATE
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What hormones are produced by the adrenal gland and maintain homeostasis? - CORRECT ANSWER
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-Corticosteroids/glucocorticoids/steroids
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What is an endogenous glucocorticoid? - CORRECT ANSWER -Cortisol
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What are the 3 categories of steroid hormones? - CORRECT ANSWER -1. Glucocorticoids
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2. Mineralcorticoids

3. Adrenal Sex Hormones n n




What is the MOA of corticosteroids? - CORRECT ANSWER -1. Inhibits the immune and inflammatory
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system
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2. Inhibits arachidonic acid metabolism
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3. Inhibits production of ILK-1, TNF, and other cytokines
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4. Impairs lymphocytes and inhibits tissue repair
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Examples of glucocorticoid medications - CORRECT ANSWER -hydrocortisone, prednisone,
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methyprednisolone, dexamethasone
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What is long-term glucocorticoid use indicated for? - CORRECT ANSWER -Life-threatening
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conditions or severe disabling symptoms
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What is short-term glucocorticoid use indicated for? - CORRECT ANSWER -Self-limiting conditions
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,What are the adverse effects of glucocorticoids after 6 months of use? - CORRECT ANSWER -1.
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Osteoporosis
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2. Worsens diabetic control and increases blood glucose (diabetics need more insulin)
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3. Promotes gastric secretion and causes abdominal pain, N/V (Report black tarry stools)
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When does bone density begin to decline because of a decrease in calcium from
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glucocorticosteroid use? - CORRECT ANSWER -Within the first 3 months
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General adverse effects of glucocorticosteroids - CORRECT ANSWER -1. Retains sodium and
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water
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2. Increases appetite n




3. Promotes fat deposit in cervical area and face n n n n n n n




4. Increases uric acid n n




5. Delerium, insomnia, mood alterations, anxiety n n n n




6. Adrenal suppression n




7. Poor wound healing, thin skin, acne, ocular damage
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Why must glucocorticosteroids be tapered? - CORRECT ANSWER -1.To avoid recurrent activity of
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underlying disease
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2. To avoid possible cortisol deficiency resulting from the HPA axis and HPA suppression during
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steroid therapy
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How should glucocorticosteroids be discontinued? - CORRECT ANSWER -1. Administer for short
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courses and then taper; do NOT abruptly withdrawal
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When is the ideal time to administer prednisone? - CORRECT ANSWER -In the morning
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When are glucocorticosteroids contraindicated? - CORRECT ANSWER -1. Severe infections
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,2. Allergy
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What is patient education for glucocorticosteroid use? - CORRECT ANSWER -1. Low carb, low
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sodium, and high protein diet
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2. Increase calcium and vitamin D
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3. Monitor weight, edema, blood glucose, blood pressure, potassium, electrolytes, and CBC
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What is the MOA of colchicine? - CORRECT ANSWER -Decreases inflammation by decreasing the
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movement of leukocytes into tissues containing urate crystals -- this affects the way the body responds
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to the uric acid -- DECREASES swelling and pain
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What is the indication of colchicine? - CORRECT ANSWER -Prophylaxis of gout flares in adults (or to
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treat Behcets syndrome)
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Is colchicine curative? - CORRECT ANSWER -Not a cure and does not prevent the disease from
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progressing
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What is low-dose colchicine? - CORRECT ANSWER -1.2mg followed by 0.6mg 1 hr later (for 1.8mg
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total)
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What is high-dose colchicine? - CORRECT ANSWER -1.2mg followed by 0.6mg every 4-6hours (for
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4.8mg total)
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Is high or low-dose colchicine preferred? - CORRECT ANSWER -Low-dose is AS EFFECTIVE as
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high-dose with LESS side effects
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What is the main side effect of colchicine? - CORRECT ANSWER -DIARRHEA (make sure this is in
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patient teaching)
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, What is the MOA of allopurinol (Zyloprim)? - CORRECT ANSWER -Prevents formation of uric acid by
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inhibiting xanthine oxidase
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How often is allopurinol (Zyloprim) taken? - CORRECT ANSWER -Taken DAILY to prevent formation of
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uric acid crystals
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What is important patient teaching for febuxostat (Uloric)? - CORRECT ANSWER -Gout may worsen
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initially with therapy
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What should treatment with febuxostat (Uloric) be combined with for the first 6 months? - CORRECT
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ANSWER -Patients should be treated with NSAIDs concurrently
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What are the lab values to monitor in gout? - CORRECT ANSWER -1. BUN
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2. Creatinine

3. LFTs (most anti-gout meds can be associated with hepatotoxicity
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4. Uric acid levels n n




What is the MOA of uricosuric agents? - CORRECT ANSWER -Inhibit renal tubular reabsorption of
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urate = increased renal excretion of uric acid
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What are examples of uricosuric agents? - CORRECT ANSWER -Probenecid and sulfinpyrazone
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What type of diet should be avoided in patients with gout? - CORRECT ANSWER -Alkaline diet to reduce
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urates; NO liver, kidney, anchovies, scallops, trout, codfish, mussels, and bacon
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What should not be used in combination with probenecid? - CORRECT ANSWER -NO ASA or
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salicylates
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