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NURS 5315 Exam 2 (100+ Questions) – Immunity, Hypersensitivities, Anemia, HIV/AIDS – UTA

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This exam study document contains over 100 detailed questions and answers designed for NURS 5315 – Advanced Pathophysiology at the University of Texas at Arlington (UTA), academic year 2025/2026. It offers a comprehensive and clinically relevant review of immune response, inflammation, hematologic disorders, hypersensitivity reactions, infectious diseases, and coagulopathies. Key areas of focus include: Immune system mechanisms: mast cells, cytokines, prostaglandins, complement system, leukotrienes, and the arachidonic pathway Hypersensitivity types I–IV with clinical examples like Graves’ disease, Guillain-Barré syndrome, lupus, myasthenia gravis, and transplant rejection Autoimmunity and alloimmunity mechanisms and management Hematologic conditions such as anemias (iron, folate, B12, sickle cell), leukemias (ALL, AML, CML, CLL), multiple myeloma, and lymphomas HIV/AIDS pathophysiology, diagnostic criteria, opportunistic infections, and antiretroviral therapy Coagulation disorders: hemophilia A & B, thrombocytopenia (ITP, HIT), DIC, and the effects of anticoagulants like warfarin, heparin, and direct thrombin inhibitors With clinical implications integrated throughout, this Q&A resource is an ideal review for students in: Nurse Practitioner (NP) programs Doctor of Nursing Practice (DNP) tracks BSN-to-MSN bridge programs Physician Assistant (PA) and PharmD programs Pre-med and allied health fields focusing on advanced pathophysiology This guide is tailored to help learners prepare for graduate-level exams, board certifications, and clinical decision-making scenarios. Keywords: NURS 5315, UTA, pathophysiology, immune system, mast cells, cytokines, hypersensitivity reactions, autoimmunity, lupus, HIV AIDS, anemia types, folate deficiency, iron deficiency, sickle cell anemia, leukemia, lymphoma, DIC, thrombocytopenia, hemophilia, coagulation cascade, antiretroviral therapy, transplant rejection, prostaglandins, complement system

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Uploaded on
October 5, 2025
Number of pages
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Written in
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NURS 5315 UTA Exam 2 2025/2026 Exam
Questions and Correct Answers | New
Update



HIV EIA (3rd generation immunoassay) - 🧠 ANSWER ✔✔can use urine,

saliva, or serum (most accurate), need to wait until 12 weeks post exposure

to see antibodies, >99% accurate

4th generation immunoassay- "gold standard"

measures P24 antigen

can test 10 days post exposure


Mast cell - 🧠 ANSWER ✔✔Cellular bags of granules located in loose

connective tisssue close to blood vessels. Activation initiates inflammatory

process.

,Histamine - 🧠 ANSWER ✔✔Causes vasodilation, increases vascular

permeability, increases blood flow to the site of injury- causes erythema

and swelling.


Cytokines - 🧠 ANSWER ✔✔Soluble factors that contribute to the regulation

of innate or adaptive resistance by affecting other neighboring cells. Can be

pro-inflammatory or anti-inflammatory. Can react quickly or be more

delayed.


Leukotrines - 🧠 ANSWER ✔✔Released when mast cells degranulate,

prolong the inflammatory process. Cause vasodilation, attract neutrophils,

monocytes, and eosinophils.target of inhibition for singular.


Prostaglandins - 🧠 ANSWER ✔✔Released when mast cells degranulate,

are produced by the arachidonic pathway. Cause vasodilation, platelet

aggregation at site of injury, pain, and fever.


Chemotactic factors - 🧠 ANSWER ✔✔Biochemical substance that attracts

leukocyte to the site of inflammation


Neutrophils - 🧠 ANSWER ✔✔Predominant leukocyte at work during the

early stages of acute inflammation

, Monocytes - 🧠 ANSWER ✔✔Become macrophages when entering the

tissue, responsible for presenting antigens to the CD4 cell which triggers T-

cell immunity and B-cell immunity.

Releases additional cytokines IL1, IL6, TNF.


Cytokine IL1 function - 🧠 ANSWER ✔✔Causes fever, activates phagocytes

& lymphocytes and also increases the release of IL6a


Cytokine IL6 function - 🧠 ANSWER ✔✔Stimulates production of acute

phase reactants and promotes growth and stimulation of RBCs


Cytokine TNF function - 🧠 ANSWER ✔✔Causes fever, increases synthesis

of proinflammatory proteins by liver, causes muscle wasting, induces

thrombosis


Cytokine growth factor function - 🧠 ANSWER ✔✔Promotes production and

maturation of neutrophils


Complement - 🧠 ANSWER ✔✔Functions include bacterial lysis,

vasodilation and increased vascular permeability, triggers mast cell

degranulation, chemotaxis, and opsonization.




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