APEA FNP Study Guide 2025/2026
Health Promotion & Disease Prevention (15 Questions)
1. A 45-year-old patient with no personal history of cardiovascular disease asks
about starting a daily aspirin for primary prevention. What is the recommended
guidance?
ANSWER ✓ The US Preventive Services Task Force (USPSTF) recommends against
initiating low-dose aspirin for the primary prevention of CVD in adults 60 years or older.
For adults aged 40-59 with a 10% or greater 10-year CVD risk, the decision to initiate
low-dose aspirin should be an individual one, as the net benefit is small. The potential
risk of bleeding must be weighed against the potential benefit.
2. At what age should average-risk adults begin screening for colorectal cancer
according to the USPSTF?
ANSWER ✓ Screening for colorectal cancer should begin at age 45 and continue
through age 75. The decision to screen adults aged 76-85 should be an individual one,
based on prior screening history, overall health, and life expectancy.
3. A 25-year-old sexually active female requests screening. Which test is
recommended for cervical cancer screening?
ANSWER ✓ For individuals aged 21-29, cervical cancer screening should be performed
with a Pap test (cytology) alone every 3 years. HPV co-testing is not recommended in
this age group.
4. What is the single most effective intervention for preventing hospital-acquired
infections?
ANSWER ✓ Proper and consistent hand hygiene is the single most effective intervention
for preventing the transmission of healthcare-associated infections.
5. A newborn's mother is HBsAg-negative. What is the recommended hepatitis B
vaccination schedule for the infant?
ANSWER ✓ The infant should receive the first dose of the hepatitis B vaccine within 24
hours of birth. The second dose is given at 1-2 months, and the third dose between 6-
18 months.
, 6. A 55-year-old patient with a 30-pack-year smoking history is currently
asymptomatic. What is the recommended lung cancer screening?
ANSWER ✓ Annual screening for lung cancer with low-dose computed tomography
(LDCT) is recommended for adults aged 50 to 80 years who have a 20 pack-year
smoking history and currently smoke or have quit within the past 15 years.
7. For a 65-year-old female with osteoporosis, what supplements are crucial for
bone health?
ANSWER ✓ Adequate Calcium (1200 mg/day from diet and supplements) and Vitamin D
(800-1000 IU/day) are essential for maintaining bone health and supporting
pharmacologic treatment.
8. What is the recommended daily physical activity for adults?
ANSWER ✓ Adults should engage in at least 150 minutes of moderate-intensity aerobic
activity or 75 minutes of vigorous-intensity aerobic activity per week, along with muscle-
strengthening activities on 2 or more days.
9. A 1-month-old infant is brought in for a well-child visit. Which immunization is
typically administered at this time?
ANSWER ✓ The second dose of the Hepatitis B vaccine is typically given at 1-2 months
of age.
10. According to the "5 A's" model for behavioral change, what follows "Assess"?
ANSWER ✓ The "5 A's" model sequence is: Ask, Advise, Assess, Assist, Arrange.
11. What is the primary goal of motivational interviewing?
ANSWER ✓ To resolve ambivalence and elicit behavior change by helping the patient
explore and resolve their own mixed feelings, rather than by direct persuasion.
12. A patient wants to quit smoking. What first-line pharmacotherapy is
contraindicated in a patient with a history of seizures?
ANSWER ✓ Bupropion (Zyban) is contraindicated in patients with a history of seizures or
an eating disorder.
13. When is the inactivated influenza vaccine (IIV) contraindicated?
Health Promotion & Disease Prevention (15 Questions)
1. A 45-year-old patient with no personal history of cardiovascular disease asks
about starting a daily aspirin for primary prevention. What is the recommended
guidance?
ANSWER ✓ The US Preventive Services Task Force (USPSTF) recommends against
initiating low-dose aspirin for the primary prevention of CVD in adults 60 years or older.
For adults aged 40-59 with a 10% or greater 10-year CVD risk, the decision to initiate
low-dose aspirin should be an individual one, as the net benefit is small. The potential
risk of bleeding must be weighed against the potential benefit.
2. At what age should average-risk adults begin screening for colorectal cancer
according to the USPSTF?
ANSWER ✓ Screening for colorectal cancer should begin at age 45 and continue
through age 75. The decision to screen adults aged 76-85 should be an individual one,
based on prior screening history, overall health, and life expectancy.
3. A 25-year-old sexually active female requests screening. Which test is
recommended for cervical cancer screening?
ANSWER ✓ For individuals aged 21-29, cervical cancer screening should be performed
with a Pap test (cytology) alone every 3 years. HPV co-testing is not recommended in
this age group.
4. What is the single most effective intervention for preventing hospital-acquired
infections?
ANSWER ✓ Proper and consistent hand hygiene is the single most effective intervention
for preventing the transmission of healthcare-associated infections.
5. A newborn's mother is HBsAg-negative. What is the recommended hepatitis B
vaccination schedule for the infant?
ANSWER ✓ The infant should receive the first dose of the hepatitis B vaccine within 24
hours of birth. The second dose is given at 1-2 months, and the third dose between 6-
18 months.
, 6. A 55-year-old patient with a 30-pack-year smoking history is currently
asymptomatic. What is the recommended lung cancer screening?
ANSWER ✓ Annual screening for lung cancer with low-dose computed tomography
(LDCT) is recommended for adults aged 50 to 80 years who have a 20 pack-year
smoking history and currently smoke or have quit within the past 15 years.
7. For a 65-year-old female with osteoporosis, what supplements are crucial for
bone health?
ANSWER ✓ Adequate Calcium (1200 mg/day from diet and supplements) and Vitamin D
(800-1000 IU/day) are essential for maintaining bone health and supporting
pharmacologic treatment.
8. What is the recommended daily physical activity for adults?
ANSWER ✓ Adults should engage in at least 150 minutes of moderate-intensity aerobic
activity or 75 minutes of vigorous-intensity aerobic activity per week, along with muscle-
strengthening activities on 2 or more days.
9. A 1-month-old infant is brought in for a well-child visit. Which immunization is
typically administered at this time?
ANSWER ✓ The second dose of the Hepatitis B vaccine is typically given at 1-2 months
of age.
10. According to the "5 A's" model for behavioral change, what follows "Assess"?
ANSWER ✓ The "5 A's" model sequence is: Ask, Advise, Assess, Assist, Arrange.
11. What is the primary goal of motivational interviewing?
ANSWER ✓ To resolve ambivalence and elicit behavior change by helping the patient
explore and resolve their own mixed feelings, rather than by direct persuasion.
12. A patient wants to quit smoking. What first-line pharmacotherapy is
contraindicated in a patient with a history of seizures?
ANSWER ✓ Bupropion (Zyban) is contraindicated in patients with a history of seizures or
an eating disorder.
13. When is the inactivated influenza vaccine (IIV) contraindicated?
