Georgette Module 1 & 2 Questions and
Answers
Lithium level
Ans: 0.6-1.2
Lithium toxicity level
Ans: greater than or equal to 1.5
what is the gold standard for treating manic episodes?
Ans: Lithium
What drug has evidence of anti-suicidal effects for bipolar
disorder?
Ans: Lithium
baseline labs to collect in order to R/O medical diagnoses prior to
giving Lithium
Ans: TSH (r/o bipolar)
Creatinine (0.6-1.2)
BUN (10-20)
Pregnancy test
ECG if greater than 50 (inverted T-waves)
All psychotropics should have what test prior to giving for child-
bearing age?
Ans: pregnancy test
what is considered child-bearing age?
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, 2 | Page
Ans: 12-51
SE of Lithium? (endocrine)
Ans: HYPOthyroidism
SE of Lithium? (CNS)
Ans: **course hand tremors w/ toxicity
SE of Lithium? (dermatological)
Ans: Maculopapular rash
SE of Lithium? (GI)
Ans: diarrhea, vomiting, cramp, anorexia
**imp. because these become severe w/ toxicity
SE of Lithium? (Renal)
Ans: diabetes insipidus (polyuria r/t polydipsia)
SE of Lithium? (Cardiac)
Ans: T-wave inversions
SE of Lithium? (Hematologic)
Ans: leukocytosis (increased WBC)
Hypertensive Crisis occurs when.....
Ans: MAOIs are taken in conjunction w/ foods containing TYRAMINE
(dietary precursor of NE)
Hypertensive crisis is _____-__________ and cannot be reversed
unless.....
Ans: life-threatening & cannot be reversed unless more MAO is produced
by the body
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Hypertensive crisis & death can occur when MAOIs are taken in
conjunction with which types of meds??
Ans: ***Meperidine
***Stimulants/other sympathomimetics
Decongestants/TCA/SGA/St. Johns Wort/L-tryptophan
Symptoms of Hypertensive crisis include
Ans: sudden explosive-like HA in OCCIPITAL region
Fever**
Treatment of Hypertensive Crisis
Ans: 1. d/c offending agent (MAOI)
2. administer PHENTOLAMINE
3. Stabilize fever
medication to reverse hypertensive crisis w/ MAOI?
Ans: Phentolamine****
List of common MAOIs (don't need to memorize, just know what
it looks like)
Ans: Isocarboxazid (Marplan)
Phenelzine (Nardil)
Selegiline (Emsam)
Tranylcypromine (Parnate)
Teratogenic risks of common psych meds (Benzo, Carbamazepine,
Lithium, Depakote)
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Ans: Benzo: floppy baby & cleft palate
Carbamazepine: neural tube defect
Lithium: Epstein's anomaly & Congenital heart defects (esp. 1st
trimester)
Depakote: Neural tube defects (spec. spina bifida)
Lamicatal main SE
Ans: Steven Johnson's Syndrome*** (SE below, KNOW)
- Fever**
- Sore throat (may feel like burning**
- Facial/tongue swelling**
- Skin sloughing***
- Prodromal HA, malaise, Arthralgia, painful mucous membranes may
occur BEFORE rash
Valproic Acid/Divalproex Sodium aka Depakote main SE
Ans: Hepatotoxicity**
Pancreatitis**
Carbamazepine (Tegretol) main SE
Ans: Agranulocytosis***
Aplastic Anemia***
Steven-Johnson's*** (mainly Asians HLAB-1502 allele)
Aplastic Anemia s/s
Ans: pallor, fatigue, HA, fever, nose bleeds, bleeding gums, skin rash,
SOB
Carbamazepine when to d/c
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