NUR 239 Pathopharm I Exam I – Questions With
Correct Solutions
Save
Practice questions for this set
Learn 1 /7 Study with Learn
chronic progressive degenerative neurologic condition (dopamine neurons
are destroyed) leading to gradual destruction of pigmented dopamine-
producing cells in substantia nigra. This causes dopamine deficiency and
abnormal CNS function, leading to an inability to control unwanted
movements.
Choose an answer
Huntington's disease
1 Basal Ganglia 2
pathophysiology
Parkinson's Disease
3 Parkinson's Clinical Manifestations 4
Pathophysiology
Don't know?
Terms in this set (127)
, paired groups of grey matter at base of brain that
Basal Ganglia
connects substantia nigra to corpus striatum
coordination of gross movement without conscious
thought (ex. Getting up to throw something away),
Basal Ganglia Function
maintenance of muscle tone, smooth, involuntary
movement
Substantia Nigra dark black bands of gray matter in midbrain
has cells that produce dopamine, which controls
Substantia Nigra Function
body movements
chronic progressive degenerative neurologic
condition (dopamine neurons are destroyed)
leading to gradual destruction of pigmented
Parkinson's Disease
dopamine-producing cells in substantia nigra. This
Pathophysiology
causes dopamine deficiency and abnormal CNS
function, leading to an inability to control unwanted
movements.
Parkinson's Clinical Three cardinal signs: 1st: Tremors (pill rolling), rigidity
Manifestations (akinesia), Bradykinesia (inability to move)
Neurologist consult --> CT, or MRI (used to rule out
Parkinson's tumors, etc), Datscan (IV injection radioactive tracer
Assessment/Diagnosis that detects smaller signal in brain of those who
have it), PET scan (visualize dopamine neurons)
Two classes of medications: 1. increase dopamine
(dopaminergic; ex. Levodopa), 2. block
Parkinson's
acetylcholine (anticholinergic; Benztropine
Pharmacologic
mesylate). Medications lead to positive expected
Management
outcomes (absence of tremors, decrease in rigidity,
decrease stiffness, increase ability to perform ADLs)
Highly individualized; goal is to relieve symptoms
Parkinson's Therapeutic
and keep functional (support groups, education,
Interventions
exercise, nutrition, physical/speech therapy)
Involuntary shaking or movement of a limb, normally
Resting Tremors
improving or ceasing with purposeful movement
Bradykinesia inability to move; "frozen in place"
Correct Solutions
Save
Practice questions for this set
Learn 1 /7 Study with Learn
chronic progressive degenerative neurologic condition (dopamine neurons
are destroyed) leading to gradual destruction of pigmented dopamine-
producing cells in substantia nigra. This causes dopamine deficiency and
abnormal CNS function, leading to an inability to control unwanted
movements.
Choose an answer
Huntington's disease
1 Basal Ganglia 2
pathophysiology
Parkinson's Disease
3 Parkinson's Clinical Manifestations 4
Pathophysiology
Don't know?
Terms in this set (127)
, paired groups of grey matter at base of brain that
Basal Ganglia
connects substantia nigra to corpus striatum
coordination of gross movement without conscious
thought (ex. Getting up to throw something away),
Basal Ganglia Function
maintenance of muscle tone, smooth, involuntary
movement
Substantia Nigra dark black bands of gray matter in midbrain
has cells that produce dopamine, which controls
Substantia Nigra Function
body movements
chronic progressive degenerative neurologic
condition (dopamine neurons are destroyed)
leading to gradual destruction of pigmented
Parkinson's Disease
dopamine-producing cells in substantia nigra. This
Pathophysiology
causes dopamine deficiency and abnormal CNS
function, leading to an inability to control unwanted
movements.
Parkinson's Clinical Three cardinal signs: 1st: Tremors (pill rolling), rigidity
Manifestations (akinesia), Bradykinesia (inability to move)
Neurologist consult --> CT, or MRI (used to rule out
Parkinson's tumors, etc), Datscan (IV injection radioactive tracer
Assessment/Diagnosis that detects smaller signal in brain of those who
have it), PET scan (visualize dopamine neurons)
Two classes of medications: 1. increase dopamine
(dopaminergic; ex. Levodopa), 2. block
Parkinson's
acetylcholine (anticholinergic; Benztropine
Pharmacologic
mesylate). Medications lead to positive expected
Management
outcomes (absence of tremors, decrease in rigidity,
decrease stiffness, increase ability to perform ADLs)
Highly individualized; goal is to relieve symptoms
Parkinson's Therapeutic
and keep functional (support groups, education,
Interventions
exercise, nutrition, physical/speech therapy)
Involuntary shaking or movement of a limb, normally
Resting Tremors
improving or ceasing with purposeful movement
Bradykinesia inability to move; "frozen in place"
