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Anti-Ulcer drugs help by: - 🧠 ANSWER ✔✔-altering gastric pH by
decreasing acid secretion
-protecting the stomach wall lining by increasing mucosal protection
-eradicating harmful bacteria Ex: H. Pylori
What are the main pharmacologic categories of drugs we used to manage
gastric acid secretion and the effects: - 🧠 ANSWER ✔✔-antacids
-H2 receptor antagonists
-proton pump inhibitors (PPIs)
-prostoglandin analogs
-mucosal protectant sulcrafate (Carafate)
,What is the first OTC medication tried by patients with dyspepsia? - 🧠
ANSWER ✔✔-Antacids
-->these are typically not effective for persistant GERD and PUD
What are antacids? How do they work? - 🧠 ANSWER ✔✔-organic salts
-neutralize the hydrochloric acid in the stomach
-raises the gastric pH above 4.0
What are the main side effects of antacids? - 🧠 ANSWER ✔✔-diarrhea
-constipation
What are the different categories of antacids? - 🧠 ANSWER ✔✔-calcium
carbonate
-sodium bicarbonate
-aluminum based
-magnesium based
-aluminum hydroxide
,What is important teaching for patients taking antacids? - 🧠 ANSWER ✔✔-
decreasing the stomach pH can cause the decrease absorption of drugs
that rely on acidic conditions
-if taking enteric coated medications--reducing stomach acid can cause the
medication to dissolve and absorb in the stomach instead of the intestine
**always separate antacids from other medications by 2 hours**
Calcium carbonate antacids: - 🧠 ANSWER ✔✔-Tums
-can cause CONSTIPATION
-require adequate fluid intake to dissolve
-can be used in patients needing to take an antacid who also could benefit
from extra calcium intake. -potential for milk "alkali" syndrome, metabolic
alkalosis
Sodium Bicarbonate antacids: - 🧠 ANSWER ✔✔-Alka Seltzer
-contains aspirin (ASA)
-potential to WORSEN GI distress. -increased risk for water retention and
fluid overload
-potential to cause hypertension
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, -Contraindicated in pregnancy, children, patient with CVD*
Aluminum based antacids: - 🧠 ANSWER ✔✔-Amphogel
-can cause CONSTIPATION
-requires adequate fluid intake to dissolve
-Contraindicated in patients with renal insufficiency*
Magnesium based antacids: - 🧠 ANSWER ✔✔-Milk of magnesia
-suspension mixture is more effective
-can cause DIARRHEA
-Contraindicated in renal insufficiency*
Aluminum hydroxide antacids: - 🧠 ANSWER ✔✔-may decrease the
absorption of warfarin*. -can cause a chelating affect with drugs such as
tetracyclines, warfarin, and digoxin—potentially decreasing their absorption
& effectiveness -high affinity for phosphate—may cause hypophasphatemia
What can cause heartburn in pregnancy? - 🧠 ANSWER ✔✔-hormonal
fluctuations
-anatomic changes