ASCP Exam Review Hematology UPDATED ACTUAL Questions
and CORRECT Answers
1. Factor IX Hemophilia B or Christmas disease deficient in factor
2. 5 M urea related fac- Factor XIII
tor deficiency
3. Factor XIII Stabilizes the final fibrin clot. When decreases or dysfunctional, fibrin clots
dissolve when 5 M urea is present. Normally the clot would not dissolve
4. G6PD Heinz bodies, spherocytes with blisters (eccentrocytes), denatured hemo-
globin (low HCT), target cells, acanthocytes, smudge cells, schistocytes
5. Pyruvate kinase defi- normocytic, normochromic anemia, poikilocytosis, anisocytosis
ciency
6. Iron deficiency ane- microcytic hypochromic anemia
mia (IDA)
7. Megaloblastic ane- macrocytic, normochromic anemia with abnormal RBC development
mia
8. Delta-beta tha- Decrease in Hb A and A2. Increase in Hb F. Due to a deletion in both delta
lassemia minor and beta genes on chromosome 11 (prevents production of Hbs A and A2).
Gamma genes on chromosome increase production of gamma globin thus
increasing Hb F.
9. Hydroxyurea Sickle cell patient therapeutic agent
10. Test results that indi- Decreased reticulocyte count. Indicates halt in RBC production
cate sickle patient is
in aplastic crisis
11. Stain for bone mar- Romanowsky and Prussian blue
row eval
, ASCP Exam Review Hematology UPDATED ACTUAL Questions
and CORRECT Answers
12. Chediak-Higashi syn- large peroxidase positive lysosomes
drome
13. Plasma cells
14. PLT count in iron defi- Increased
ciency anemia
15. Facts about IDA Iron Deficiency Anemia
-most common cause of anemia in children 6 mo to 24 mo
-iron stores at birth last for 4-6mo
-adult males store iron of 1 gram and unlikely to become iron deficient in
absence of chronic bleeding
16. Liver disease and vit- decreased bile salt synthesis leads to impaired Vit. K absorption and
amin K deficiency deficiency. Obstructive jaundice, Vit. K deficiency results from impaired
intestinal absorption
17. M:E ratio Myeloid to erythroid cells
18. Atypical RBCs seen acanthocytes, echinocytes, target cells, spherocytes and schistocytes due to
in peripheral smear the spleen being removed these RBCs are not filtered out of the circulation
of postsplenectomy
syndrome
19. Tartrate resistant acid Performed on blood cells or BM to confirm hairy cell leukemia
phosphatase (TRAP)
, 20. How are schistocytes Microthrombi disposition in small vessesl:
caused in disseminat-
ed intravascular coag Result of erythrocytic membrane damage due to sheering RBCs as they
(DIC) pass through the fibrin mesh of clot formation in blood vessels
Also seen in TTP and HUS
21. None corrected aPTT No change with the addition of factors in pooled normal plasma
due to coagulation in-
hibitor
22. Beta thalassemia A decrease in the rate of production of beta chains due to a partial or total
deletion of loci from chromosome 11 that code for the beta chain
23. Conditions associat- Hereditary spherocytosis and autoimmune hemolytic anemia
ed with spherocytosis
24. Bart's Hemoglobin Hemoglobin H formed by gamma chain production decreases, beta chain
production increases and form beta chain tetramers all due to alpha tha-
lassemia intermedia forming low alpha chains
25. Iron overload serum 200 ng/mL
ferritin level and
hereditary
hemochromatosis in
pre-menopausal
women
26. Early symptom of he- joint pain
mochromatosis
27. Late symptoms of he- cirrhosis of the liver, diabetes and cardiomyopathy
mochromatosis
and CORRECT Answers
1. Factor IX Hemophilia B or Christmas disease deficient in factor
2. 5 M urea related fac- Factor XIII
tor deficiency
3. Factor XIII Stabilizes the final fibrin clot. When decreases or dysfunctional, fibrin clots
dissolve when 5 M urea is present. Normally the clot would not dissolve
4. G6PD Heinz bodies, spherocytes with blisters (eccentrocytes), denatured hemo-
globin (low HCT), target cells, acanthocytes, smudge cells, schistocytes
5. Pyruvate kinase defi- normocytic, normochromic anemia, poikilocytosis, anisocytosis
ciency
6. Iron deficiency ane- microcytic hypochromic anemia
mia (IDA)
7. Megaloblastic ane- macrocytic, normochromic anemia with abnormal RBC development
mia
8. Delta-beta tha- Decrease in Hb A and A2. Increase in Hb F. Due to a deletion in both delta
lassemia minor and beta genes on chromosome 11 (prevents production of Hbs A and A2).
Gamma genes on chromosome increase production of gamma globin thus
increasing Hb F.
9. Hydroxyurea Sickle cell patient therapeutic agent
10. Test results that indi- Decreased reticulocyte count. Indicates halt in RBC production
cate sickle patient is
in aplastic crisis
11. Stain for bone mar- Romanowsky and Prussian blue
row eval
, ASCP Exam Review Hematology UPDATED ACTUAL Questions
and CORRECT Answers
12. Chediak-Higashi syn- large peroxidase positive lysosomes
drome
13. Plasma cells
14. PLT count in iron defi- Increased
ciency anemia
15. Facts about IDA Iron Deficiency Anemia
-most common cause of anemia in children 6 mo to 24 mo
-iron stores at birth last for 4-6mo
-adult males store iron of 1 gram and unlikely to become iron deficient in
absence of chronic bleeding
16. Liver disease and vit- decreased bile salt synthesis leads to impaired Vit. K absorption and
amin K deficiency deficiency. Obstructive jaundice, Vit. K deficiency results from impaired
intestinal absorption
17. M:E ratio Myeloid to erythroid cells
18. Atypical RBCs seen acanthocytes, echinocytes, target cells, spherocytes and schistocytes due to
in peripheral smear the spleen being removed these RBCs are not filtered out of the circulation
of postsplenectomy
syndrome
19. Tartrate resistant acid Performed on blood cells or BM to confirm hairy cell leukemia
phosphatase (TRAP)
, 20. How are schistocytes Microthrombi disposition in small vessesl:
caused in disseminat-
ed intravascular coag Result of erythrocytic membrane damage due to sheering RBCs as they
(DIC) pass through the fibrin mesh of clot formation in blood vessels
Also seen in TTP and HUS
21. None corrected aPTT No change with the addition of factors in pooled normal plasma
due to coagulation in-
hibitor
22. Beta thalassemia A decrease in the rate of production of beta chains due to a partial or total
deletion of loci from chromosome 11 that code for the beta chain
23. Conditions associat- Hereditary spherocytosis and autoimmune hemolytic anemia
ed with spherocytosis
24. Bart's Hemoglobin Hemoglobin H formed by gamma chain production decreases, beta chain
production increases and form beta chain tetramers all due to alpha tha-
lassemia intermedia forming low alpha chains
25. Iron overload serum 200 ng/mL
ferritin level and
hereditary
hemochromatosis in
pre-menopausal
women
26. Early symptom of he- joint pain
mochromatosis
27. Late symptoms of he- cirrhosis of the liver, diabetes and cardiomyopathy
mochromatosis
