l THE BIOLOGIC BASIS FOR DISEASE IN ADULTS AND
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l CHILDREN 8th Edition Kathryn L. McCance, Sue E. Huether
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Contents
Chapter 01: Cellular Biology ................................................................................................. 4
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Chapter 02: Altered Cellular and Tissue Biology: Environmental Agents ........................... 18
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Chapter 03: The Cellular Environment: Fluids and Electrolytes, Acids and Bases ...............31
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Chapter 04: Genes and Genetic Diseases ............................................................................ 44
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Chapter 05: Genes, Environment-Lifestyle, and Common Diseases................................... 55
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Chapter 06: Epigenetics and Disease .................................................................................. 63
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Chapter 07: Innate Immunity: Inflammation and Wound Healing..................................... 68
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Chapter 08: Adaptive Immunity......................................................................................... 83
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Chapter 09: Alterations in Immunity and Inflammation .................................................... 95
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Chapter 10: Infection ........................................................................................................ 108
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Chapter 11: Stress and Disease ........................................................................................... 117
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Chapter 12: Cancer Biology ............................................................................................... 124
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Chapter 13: Cancer Epidemiology...................................................................................... 137
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Chapter 14: Cancer in Children ......................................................................................... 143
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Chapter 15: Structure and Function of the Neurologic System ........................................... 148
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Chapter 16: Pain, Temperature Regulation, Sleep, and Sensory Function..........................159
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Chapter 17: Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor
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Function............................................................................................................................174
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Chapter 18: Disorders ofthe Central and Peripheral Nervous Systems and the
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Neuromuscular Junction
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............ 188
Chapter 19: Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders 199
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Chapter 20: Alterations ofNeurologic Function in Children ............................................. 206
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Chapter 21: Mechanisms of Hormonal Regulation............................................................. 213
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Chapter 22: Alterations of Hormonal Regulation .............................................................. 222
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Chapter 23: Obesity and Disorders of Nutrition ................................................................ 234
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Chapter 24: Structure and Function of the Reproductive Systems .................................... 239
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Chapter 25: Alterations of the Female Reproductive System ............................................ 249
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Chapter 26: Alterations of the Male Reproductive System ................................................ 259
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Chapter 27: Sexually Transmitted Infections ................................................................... 265
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Chapter 28: Structure and Function of the Hematologic System ....................................... 273
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Chapter 29: Alterations ofErythrocytes, Platelets, and Hemostatic Function ................... 283
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Chapter 30: Alterations of Leukocyte and Lymphoid Function ......................................... 293
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Chapter 31: Alterations of Hematologic Function in Children ........................................... 300
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Chapter 32: Structure and Function of the Cardiovascular and Lymphatic Systems........... 311
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Chapter 33: Alterations of Cardiovascular Function ......................................................... 324
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Chapter 34: Alterations of Cardiovascular Function in Children ....................................... 338
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Chapter 35: Structure and Function of thePulmonary System .......................................... 346
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Chapter 36: Alterations ofPulmonary Function ............................................................... 356
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Chapter 37: Alterations ofPulmonary Function in Children ..............................................373
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Chapter 38: Structure and Function of the Renal and Urologic Systems .............................381
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Chapter 39: Alterations ofRenal and Urinary Tract Function............................................. 391
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Chapter 40: Alterations of Renal and Urinary Tract Function in Children ......................... 401
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Chapter 41: Structure and Function of the Digestive System ............................................. 409
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Chapter 42: Alterations of Digestive Function ...................................................................421
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Chapter 43: Alterations of Digestive Function in Children ................................................ 432
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Chapter 44: Structure and Function of the Musculoskeletal System ...................................441
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Chapter 45: Alterations of Musculoskeletal Function ....................................................... 453
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Chapter 46: Alterations of Musculoskeletal Function in Children..................................... 466
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Chapter 47: Structure, Function, and Disorders of the Integument ................................... 475
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Chapter 48: Alterations of the Integument in Children ..................................................... 486
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Chapter 49: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults ............. 494
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Chapter 50: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children ......... 502
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l CHILDREN 8th Edition Kathryn L. McCance, Sue E. Huether
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, l 2
Contents
Chapter 01: Cellular Biology ................................................................................................. 4
l l l
Chapter 02: Altered Cellular and Tissue Biology: Environmental Agents ........................... 18
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Chapter 03: The Cellular Environment: Fluids and Electrolytes, Acids and Bases ...............31
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Chapter 04: Genes and Genetic Diseases ............................................................................ 44
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Chapter 05: Genes, Environment-Lifestyle, and Common Diseases................................... 55
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Chapter 06: Epigenetics and Disease .................................................................................. 63
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Chapter 07: Innate Immunity: Inflammation and Wound Healing..................................... 68
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Chapter 08: Adaptive Immunity......................................................................................... 83
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Chapter 09: Alterations in Immunity and Inflammation .................................................... 95
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Chapter 10: Infection ........................................................................................................ 108
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Chapter 11: Stress and Disease ........................................................................................... 117
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Chapter 12: Cancer Biology ............................................................................................... 124
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Chapter 13: Cancer Epidemiology...................................................................................... 137
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Chapter 14: Cancer in Children ......................................................................................... 143
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Chapter 15: Structure and Function of the Neurologic System ........................................... 148
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Chapter 16: Pain, Temperature Regulation, Sleep, and Sensory Function..........................159
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Chapter 17: Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor
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Function............................................................................................................................174
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Chapter 18: Disorders ofthe Central and Peripheral Nervous Systems and the
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Neuromuscular Junction
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......................................................................................................................................................
............ 188
Chapter 19: Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders 199
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Chapter 20: Alterations ofNeurologic Function in Children ............................................. 206
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Chapter 21: Mechanisms of Hormonal Regulation............................................................. 213
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Chapter 22: Alterations of Hormonal Regulation .............................................................. 222
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Chapter 23: Obesity and Disorders of Nutrition ................................................................ 234
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Chapter 24: Structure and Function of the Reproductive Systems .................................... 239
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Chapter 25: Alterations of the Female Reproductive System ............................................ 249
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Chapter 26: Alterations of the Male Reproductive System ................................................ 259
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Chapter 27: Sexually Transmitted Infections ................................................................... 265
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Chapter 28: Structure and Function of the Hematologic System ....................................... 273
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Chapter 29: Alterations ofErythrocytes, Platelets, and Hemostatic Function ................... 283
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Chapter 30: Alterations of Leukocyte and Lymphoid Function ......................................... 293
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Chapter 31: Alterations of Hematologic Function in Children ........................................... 300
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Chapter 32: Structure and Function of the Cardiovascular and Lymphatic Systems........... 311
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Chapter 33: Alterations of Cardiovascular Function ......................................................... 324
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Chapter 34: Alterations of Cardiovascular Function in Children ....................................... 338
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Chapter 35: Structure and Function of thePulmonary System .......................................... 346
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Chapter 36: Alterations ofPulmonary Function ............................................................... 356
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Chapter 37: Alterations ofPulmonary Function in Children ..............................................373
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Chapter 38: Structure and Function of the Renal and Urologic Systems .............................381
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Chapter 39: Alterations ofRenal and Urinary Tract Function............................................. 391
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Chapter 40: Alterations of Renal and Urinary Tract Function in Children ......................... 401
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Chapter 41: Structure and Function of the Digestive System ............................................. 409
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Chapter 42: Alterations of Digestive Function ...................................................................421
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Chapter 43: Alterations of Digestive Function in Children ................................................ 432
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Chapter 44: Structure and Function of the Musculoskeletal System ...................................441
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Chapter 45: Alterations of Musculoskeletal Function ....................................................... 453
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Chapter 46: Alterations of Musculoskeletal Function in Children..................................... 466
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Chapter 47: Structure, Function, and Disorders of the Integument ................................... 475
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Chapter 48: Alterations of the Integument in Children ..................................................... 486
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Chapter 49: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults ............. 494
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Chapter 50: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children ......... 502
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