RN ATI PHARMACOLOGY PROCTORED EXAM NEWEST
2025-2026 ACTUAL EXAM 400 QUESTIONS AND CORRECT
DETAILED ANSWERS WITH RATIONALES (VERIFIED
ANSWERS) |ALREADY GRADED A+
✅ Key Features
400 real exam-based questions with verified correct answers.
Detailed rationales/explanations for every answer.
Newest 2025–2026 edition, aligned with ATI Pharmacology standards.
Verified accuracy and graded A+ quality.
Comprehensive coverage of essential pharmacology content areas.
🎯 Who This Resource Is For
RN students preparing for the ATI Pharmacology Proctored Exam.
Learners seeking to boost NCLEX-RN readiness with trusted practice.
Nursing educators looking for a reliable exam prep resource.
Candidates wanting exam-style practice with rationales for deeper
understanding.
A nurse is providing discharge instructions for a client who has a new prescription for an
antihypertensive medication. Which of the following statements should the nurse give?
A. "Be sure to limit your potassium intake while taking the medication."
B. "You should check your blood pressure every 8 hours while taking this medication."
C. "Your medication dosage will be increased if you develop tachycardia."
D. "Change positions slowly when you move from sitting to standing." - answer-D. "Change positions
slowly when you move from sitting to standing."
(Orthostatic hypotension is a common adverse effect of antihypertensive medications. The client should
move slowly to a sitting or standing position and should be taught to sit or lie down if lightheadedness or
dizziness occurs)
,A nurse is reviewing a client's health record and notes that the client experiences permanent
extrapyramidal effects caused by a previous medication. The nurse should recognize that the medication
affected which of the following systems in the client?
A. Cardiovascular
B. Immune
C. Central nervous
D. Gastrointestinal - answer-C. Central nervous
(The nurse should realize that extrapyramidal effects are movement disorders that can be caused by a
number of central nervous system medications, such as typical antipsychotic medications)
A nurse is caring for a client who is taking oral Oxycodone The client states he is also taking Ibuprofen in
three recommended doses daily. The nurse should identify that an interaction between these two
medications will cause which of the following findings?
A. A decrease in serum levels of ibuprofen, possibly leading to a need for increased doses of this
medication
B. A decrease in serum levels of oxycodone, possibly leading to a need for increased doses of this
medication
C. An increase in the expected therapeutic effect of both medications
D. An increase in expected adverse effects for both medications - answer-C. An increase in the expected
therapeutic effect of both medications
(These medications work together to increase the pain-relieving effects of both medications. Oxycodone
is a narcotic analgesic, and ibuprofen is an NSAID. They work by different mechanisms, but pain is better
relieved when they are taken together)
A nurse is preparing to administer medications to a 4-month-old infant. Which of the following
pharmacokinetic principles should the nurse consider when administering medications to this client?
(Select all that apply.)
A. Infants have a more rapid gastric emptying time.
B. Infants have immature liver function.
C. Infants' blood-brain barrier is poorly developed.
D. Infants have an increased ability to absorb topical medications.
E. Infants have an increased number of protein-binding sites. - answer-B. Infants have immature liver
function.
,C. Infants' blood-brain barrier is poorly developed.
D. Infants have an increased ability to absorb topical medications.
(B. Infants have immature liver function until 1 year of age. The nurse should administer medications the
liver metabolizes in smaller dosages.
C. Infants have a poorly developed blood-brain barrier, which places them at risk for adverse
effects from medications that pass through the blood-brain barrier. The nurse should administer these
medications in smaller dosages.
D. Because infants have more blood flowing to the skin and their skin is thin, their medication
absorption is increased, making them prone to toxicity from topical medications)
A nurse in a provider's office is reviewing the medical record of a client who is pregnant and is at her first
prenatal visit. Which of the following immunizations may the nurse administer safely to this client?
A. Varicella vaccine
B. Rubella vaccine
C. Inactivated influenza vaccine
D. Measles vaccine - answer-C. Inactivated influenza vaccine
(During influenza season, providers recommend the inactivated influenza vaccine for women who are
pregnant)
A nurse on a medical-surgical unit administers a hypnotic medication to an older adult client at 2100.
The next morning, the client is drowsy and wants to sleep instead of eating breakfast. Which of the
following factors should the nurse identify as a possible reason for the client's drowsiness? A.
Reduced cardiac function
B. First-pass effect
C. Reduced hepatic function
D. Increased gastric motility - answer-C. Reduced hepatic function
(Older adults have reduced hepatic function, which can prolong the effects of medications the liver
metabolizes. The client probably needs a lower dosage of the hypnotic medication)
A nurse working in an emergency department is caring for a client who has Benzodiazepine toxicity due
to an overdose. Which of the following actions is the nurse's priority? A. Administer flumazenil.
B. Identify the client's level of orientation.
, C. Infuse IV fluids.
D. Prepare the client for gastric lavage - answer-B. Identify the client's level of orientation.
(The first action the nurse should take when using the nursing process is to assess the client. Identifying
the client's level of orientation is the priority action.)
A nurse is teaching a client who has a new prescription for Escitalopram for treatment of generalized
Anxiety disorder. Which of the following statements by the client indicates understanding of the
teaching?
A. "I should take the medication on an empty stomach."
B. "I will follow a low-sodium diet while taking this medication."
C. "I need to discontinue this medication slowly."
D. "I should not crush this medication before swallowing." - answer-C. "I need to discontinue this
medication slowly."
(When discontinuing escitalopram, the client should taper the medication slowly according to a
prescribed tapered dosing schedule to reduce the risk of withdrawal syndrome.)
A nurse is providing teaching to a client who has a new prescription for Buspirone to treat Anxiety.
Which of the following information should the nurse include?
A. "Take this medication on an empty stomach"
B. "Expect optimal therapeutic effects within 24 hr."
C. "Take this medication when needed for anxiety"
D. "This medication has a low risk for dependency." - answer-D. "This medication has a low risk for
dependency."
(Buspirone has a low risk for physical or psychological dependence or tolerance.)
A nurse is teaching a client who has OCD and has a new prescription for Paroxetine. Which of the
following instructions should the nurse include?
A. "It can take several weeks before you feel like the medication is helping."
B. "Take the medication just before bedtime to promote sleep."
C. "You should take the medication when needed for obsessive urges."
D. "Monitor for weight gain while taking this medication." - answer-A. "It can take several weeks before
you feel like the medication is helping."
2025-2026 ACTUAL EXAM 400 QUESTIONS AND CORRECT
DETAILED ANSWERS WITH RATIONALES (VERIFIED
ANSWERS) |ALREADY GRADED A+
✅ Key Features
400 real exam-based questions with verified correct answers.
Detailed rationales/explanations for every answer.
Newest 2025–2026 edition, aligned with ATI Pharmacology standards.
Verified accuracy and graded A+ quality.
Comprehensive coverage of essential pharmacology content areas.
🎯 Who This Resource Is For
RN students preparing for the ATI Pharmacology Proctored Exam.
Learners seeking to boost NCLEX-RN readiness with trusted practice.
Nursing educators looking for a reliable exam prep resource.
Candidates wanting exam-style practice with rationales for deeper
understanding.
A nurse is providing discharge instructions for a client who has a new prescription for an
antihypertensive medication. Which of the following statements should the nurse give?
A. "Be sure to limit your potassium intake while taking the medication."
B. "You should check your blood pressure every 8 hours while taking this medication."
C. "Your medication dosage will be increased if you develop tachycardia."
D. "Change positions slowly when you move from sitting to standing." - answer-D. "Change positions
slowly when you move from sitting to standing."
(Orthostatic hypotension is a common adverse effect of antihypertensive medications. The client should
move slowly to a sitting or standing position and should be taught to sit or lie down if lightheadedness or
dizziness occurs)
,A nurse is reviewing a client's health record and notes that the client experiences permanent
extrapyramidal effects caused by a previous medication. The nurse should recognize that the medication
affected which of the following systems in the client?
A. Cardiovascular
B. Immune
C. Central nervous
D. Gastrointestinal - answer-C. Central nervous
(The nurse should realize that extrapyramidal effects are movement disorders that can be caused by a
number of central nervous system medications, such as typical antipsychotic medications)
A nurse is caring for a client who is taking oral Oxycodone The client states he is also taking Ibuprofen in
three recommended doses daily. The nurse should identify that an interaction between these two
medications will cause which of the following findings?
A. A decrease in serum levels of ibuprofen, possibly leading to a need for increased doses of this
medication
B. A decrease in serum levels of oxycodone, possibly leading to a need for increased doses of this
medication
C. An increase in the expected therapeutic effect of both medications
D. An increase in expected adverse effects for both medications - answer-C. An increase in the expected
therapeutic effect of both medications
(These medications work together to increase the pain-relieving effects of both medications. Oxycodone
is a narcotic analgesic, and ibuprofen is an NSAID. They work by different mechanisms, but pain is better
relieved when they are taken together)
A nurse is preparing to administer medications to a 4-month-old infant. Which of the following
pharmacokinetic principles should the nurse consider when administering medications to this client?
(Select all that apply.)
A. Infants have a more rapid gastric emptying time.
B. Infants have immature liver function.
C. Infants' blood-brain barrier is poorly developed.
D. Infants have an increased ability to absorb topical medications.
E. Infants have an increased number of protein-binding sites. - answer-B. Infants have immature liver
function.
,C. Infants' blood-brain barrier is poorly developed.
D. Infants have an increased ability to absorb topical medications.
(B. Infants have immature liver function until 1 year of age. The nurse should administer medications the
liver metabolizes in smaller dosages.
C. Infants have a poorly developed blood-brain barrier, which places them at risk for adverse
effects from medications that pass through the blood-brain barrier. The nurse should administer these
medications in smaller dosages.
D. Because infants have more blood flowing to the skin and their skin is thin, their medication
absorption is increased, making them prone to toxicity from topical medications)
A nurse in a provider's office is reviewing the medical record of a client who is pregnant and is at her first
prenatal visit. Which of the following immunizations may the nurse administer safely to this client?
A. Varicella vaccine
B. Rubella vaccine
C. Inactivated influenza vaccine
D. Measles vaccine - answer-C. Inactivated influenza vaccine
(During influenza season, providers recommend the inactivated influenza vaccine for women who are
pregnant)
A nurse on a medical-surgical unit administers a hypnotic medication to an older adult client at 2100.
The next morning, the client is drowsy and wants to sleep instead of eating breakfast. Which of the
following factors should the nurse identify as a possible reason for the client's drowsiness? A.
Reduced cardiac function
B. First-pass effect
C. Reduced hepatic function
D. Increased gastric motility - answer-C. Reduced hepatic function
(Older adults have reduced hepatic function, which can prolong the effects of medications the liver
metabolizes. The client probably needs a lower dosage of the hypnotic medication)
A nurse working in an emergency department is caring for a client who has Benzodiazepine toxicity due
to an overdose. Which of the following actions is the nurse's priority? A. Administer flumazenil.
B. Identify the client's level of orientation.
, C. Infuse IV fluids.
D. Prepare the client for gastric lavage - answer-B. Identify the client's level of orientation.
(The first action the nurse should take when using the nursing process is to assess the client. Identifying
the client's level of orientation is the priority action.)
A nurse is teaching a client who has a new prescription for Escitalopram for treatment of generalized
Anxiety disorder. Which of the following statements by the client indicates understanding of the
teaching?
A. "I should take the medication on an empty stomach."
B. "I will follow a low-sodium diet while taking this medication."
C. "I need to discontinue this medication slowly."
D. "I should not crush this medication before swallowing." - answer-C. "I need to discontinue this
medication slowly."
(When discontinuing escitalopram, the client should taper the medication slowly according to a
prescribed tapered dosing schedule to reduce the risk of withdrawal syndrome.)
A nurse is providing teaching to a client who has a new prescription for Buspirone to treat Anxiety.
Which of the following information should the nurse include?
A. "Take this medication on an empty stomach"
B. "Expect optimal therapeutic effects within 24 hr."
C. "Take this medication when needed for anxiety"
D. "This medication has a low risk for dependency." - answer-D. "This medication has a low risk for
dependency."
(Buspirone has a low risk for physical or psychological dependence or tolerance.)
A nurse is teaching a client who has OCD and has a new prescription for Paroxetine. Which of the
following instructions should the nurse include?
A. "It can take several weeks before you feel like the medication is helping."
B. "Take the medication just before bedtime to promote sleep."
C. "You should take the medication when needed for obsessive urges."
D. "Monitor for weight gain while taking this medication." - answer-A. "It can take several weeks before
you feel like the medication is helping."
