NRNP 6665 MIDTERM EXAM QUESTIONS AND
ANSWERS LATEST ()
Surgery risk classes - ANSWER-Class 1: benefits outweigh risk, should be done
Class 2a: reasonable to perform
Class 2b: should be considered
Class 3: rarely appropriate
General rules for surgery: testing - ANSWER-ECG before surgery only if coronary disease, except when
low risk surgery
Stress test not indicated before surgery
Do not do prophylactic coronary revascularization
Meds before surgery - ANSWER-- Diabetic agents: Use insulin therapy to maintain glycemic goals(iii)
Discontinue biguanides, alpha glucosidase inhibitors, thiazolidinediones, sulfonylureas, and GLP-1
agonists
- Do not start aspirin before surgery
- Stop Warfarin 5 days before surgery. May be bridged with Lovenox.
- Do not stop statin before surgery
- Do not start beta-blocker on day of surgery, but may continue
Assessment of surgical risk - ANSWER-- Unstable cardiac condition (recent MI, active angina, active HF,
uncontrolled HTN, severe valvular disease), concern with CAD, CHF. arrhythmia, CVD
- patient stable or unstable?
- urgency of the procedure (oncology will be time sensitive)
- risk of procedure
- nutritional status
- immune competence
- determine functional capacity (need to be more than 4 METS, more than 10 METs makes low risk)
Low risk surgeries - ANSWER-catarcts
breast biopsy
cystoscopy, vasectomy
laporascopic procedures
Plastic surgery
intermediate risk surgeries - ANSWER-Head/ neck surgery
thyroidectomy
Intraperitoneal
Prostate
Laminectomy
Hip/ knee
Hysterectomy
cholecystectomy
nephrectomy
non majot intrathoracic
High risk surgeries - ANSWER-aortic/ cabg
transplants
spinal reconstruction
,peripheral vascular surgery
Lee's revised cardiac risk index - ANSWER-6 points:
High risk surgery = 1
CAD = 1
CHF = 1
Cerebrovascular disease = 1
DM 1 on insulin = 1
Creat greater than 2 = 1
1 = low risk
2 = moderate risk
3 = high risk
SCIP pre-operative infection measures - ANSWER-- Prophylactic antibiotics should be received within
1 h prior to surgical incision
- be selected for activity against the most probable antimicrobial contaminants
- be discontinued within 24 h after the surgery end-time
Postoperative infection reduction methods - ANSWER-- pre-op hair removal (clippers)
- wash hands
- normothermia
- maintain euglycemia
- urinary catheters are to be removed within the first two postoperative days
Osteoarthritis: what, incidence - ANSWER-Slow destruction of bones/ joint followed by production of
replacement collagen which causes inflammatory changes
- older than 60
- more female after 55
- more black than white women
- men and women equal risk between 45 - 55
- abnormal height or weight (obesity)
- repetitive movement
- prior trauma (sprains/ dislocations)
- diabetic neuropathy
- genetic
Osteoarthritis findings and diagnostics - ANSWER-- Pain in weight bearing joints
- stiffness after sitting, gets better when arising
- feeling of instability on stairs
- fine motor skills deficit
- larger affected joints
- Heberden nodules (bony bumps on the finger joint closest to the fingernail)
- Bouchard's nodules (bony bumps on the middle joint of the finger)
- limited ROM with crepitus
- xr shows narrowing of joint space (need anteroposterior and lateral knee films bilaterally)
- synovial fluid is clear and without WBC
Osteoarthritis treatment - ANSWER-Goal is to relieve symptoms, maintain/ improve function, and
avoid drug toxicity
Hand OA:
- rest/ joint protection, with splinting
- heat/ cold therapy
- topical capsaicin
,- topical NSAID (trolamine salicylate) (especially for older than 75)
- Oral NSAIDS, incl COX2 inhibitors such as celecoxib (Celebrex) (may cause cardiac problems)
- tramadol
- no opioids
Hip/ knee OA:
- weight reduction, cardiovascular exercises
- transcutanous external nerve stimulator
- acetaminophen
- Topical NSAIDS (knee)
- intraarticular corticosteroid injections
- surgery (joint replacement)
Rheumatoid arthritis: what, who - ANSWER-chronic, systemic autoimmune disease that causes
inflammation of connective tissue, first that of jionts them other soft tissues (renal, cardiovascular,
pulm). TNF-alpha plays a big role
- more women than men
- unknown cause
- Epstein Barr virus
Rheumatoid arthritis: Findings and diagnostics - ANSWER-- symmetric joint/ muscle pain, worse in the
morning then gets better
- weakness, fatigue
- anorexia, weight loss
- generalized malaise
- swollen joints/ boggy feeling of joints with deformity of joints
- warm, red skin on affected joints
later:
- pleural effusions and pulmonary nodules
- inflammation of sclerea (scleritis)
- pericarditis, myocarditis
- splenomegaly (Felty's syndrome)
- anemia (hypochromic, microcytic) with low ferritin
- possibly: positive rheumatoid factor
- XR: joint swelling, later cortical and space thinning
- synovial fluid: yellow, thick with elevated WBC up to 100.000
Felty's syndrome - ANSWER-rheumatoid arthritis, splenomegaly, neutropenia
Rheumatoid arthritis treatment - ANSWER-- early treatment better than stepwise
- early referral rheumatologist
- disease-modifying anti-rheumatic drugs (DMARDs):
- methotrexate ( no alcohol, monitor renal and liver, give with folic acid)
- cyclosporine
- Gold preparations (can cause thrombocytopenia)
- Hydroxychloroquine: antimalarial drug (may cause visual changes, monitor)
- sulfasalazine, moderate RA
- Leflunomide, moderate to severe RA
- Etanercept
- monitor liver function with DMARDs
- screen for TB (skin test) and Hep B
- surgery: joint debridement, joint replacement
Gout: what, who - ANSWER-Inflammatory disorder in response to high uric acid production/ levels in
blood and synovial fluid causing crystallization which causes inflammation (Type A and Mediterranean)
, - impaired renal function which causes excess uric acid
- foods high in purine, such as dairy, red meat, shellfish, beer
Gout findings, diagnostics - ANSWER-- acute painful joint, often great toe (warm, swollen)
- pain at night
- flank pain because of renal calculi
- fever
- leukocytosis
- elevated erythrocyte sedimentation rate
- tophi (bump under skin) on ear
- limited joint motion
- elevated serum uric acid (greater than 7mg/dl)
- urate crystals seen with joint aspiration
- xr: joint erosion and renal stones
Gout treatment - ANSWER-- NSAIDS: naproxen, ondomethacin, sulindac
- Colchicine for those who do not tolerate NSAIDS (caution with renal impairment). Also for
prophylaxis
- Corticosteroids, if NSAIDS and colchicine not tolerated
- 24hr urine for uric acid
- Allopurinol after flare is over (100mg PO daily)
- Biological modifiers of disease (BMD): Pegloticase. Not for asymptomatic. Treat with prophylaxis first.
Monitor serum uric acid
ANA. Tests in rheumatic disease: what, normal level, abnormal with. - ANSWER-Antinuclear antibody
(ANA).
Normal: Titer 1.32
POsitive with: Sjogren's (SS), SLE (lupus),
C4 Complement. Tests in rheumatic disease: what, normal level, abnormal with. - ANSWER-
Determines hemolytic activity which speaks to level of inflammatory response
Normal: men: 12-72. Women: 13-75 mg/dl
Increased with: inflammatory disease
Decreased with: RA, lupus, SS
The radioallergosorbent test (RAST). Tests in rheumatic disease: what, normal level, abnormal with. -
ANSWER-measures presence/ increase antigen IgE
normal: 0.01 - 0.04 mg/dl
Increased with allergic reaction
Erythrocyte sedimentation rate (ESR). Tests in rheumatic disease: what, normal level, abnormal with. -
ANSWER-rate at which RBC settle out of unclotted blood in 1 hr
Normal: men: 0-7mm/hr, women: 0 - 25 mm/hr
Increased with inflammation
CRP. Tests in rheumatic disease: what, normal level, abnormal with. - ANSWER-C-reactive protein, a
non-specific antigen antibody
Normal: trace to 6mg/ml
Increased with infection and inflammation, RA. Decreased with succesfull RA treatment
RF. Tests in rheumatic disease: what, normal level, abnormal with. - ANSWER-Rheumatoid factor.
antibody against IgG.
Positive RF in most people with RA
Corticosteroids and arthritis: what does it do and adverse effects - ANSWER-Not for maintenance
ANSWERS LATEST ()
Surgery risk classes - ANSWER-Class 1: benefits outweigh risk, should be done
Class 2a: reasonable to perform
Class 2b: should be considered
Class 3: rarely appropriate
General rules for surgery: testing - ANSWER-ECG before surgery only if coronary disease, except when
low risk surgery
Stress test not indicated before surgery
Do not do prophylactic coronary revascularization
Meds before surgery - ANSWER-- Diabetic agents: Use insulin therapy to maintain glycemic goals(iii)
Discontinue biguanides, alpha glucosidase inhibitors, thiazolidinediones, sulfonylureas, and GLP-1
agonists
- Do not start aspirin before surgery
- Stop Warfarin 5 days before surgery. May be bridged with Lovenox.
- Do not stop statin before surgery
- Do not start beta-blocker on day of surgery, but may continue
Assessment of surgical risk - ANSWER-- Unstable cardiac condition (recent MI, active angina, active HF,
uncontrolled HTN, severe valvular disease), concern with CAD, CHF. arrhythmia, CVD
- patient stable or unstable?
- urgency of the procedure (oncology will be time sensitive)
- risk of procedure
- nutritional status
- immune competence
- determine functional capacity (need to be more than 4 METS, more than 10 METs makes low risk)
Low risk surgeries - ANSWER-catarcts
breast biopsy
cystoscopy, vasectomy
laporascopic procedures
Plastic surgery
intermediate risk surgeries - ANSWER-Head/ neck surgery
thyroidectomy
Intraperitoneal
Prostate
Laminectomy
Hip/ knee
Hysterectomy
cholecystectomy
nephrectomy
non majot intrathoracic
High risk surgeries - ANSWER-aortic/ cabg
transplants
spinal reconstruction
,peripheral vascular surgery
Lee's revised cardiac risk index - ANSWER-6 points:
High risk surgery = 1
CAD = 1
CHF = 1
Cerebrovascular disease = 1
DM 1 on insulin = 1
Creat greater than 2 = 1
1 = low risk
2 = moderate risk
3 = high risk
SCIP pre-operative infection measures - ANSWER-- Prophylactic antibiotics should be received within
1 h prior to surgical incision
- be selected for activity against the most probable antimicrobial contaminants
- be discontinued within 24 h after the surgery end-time
Postoperative infection reduction methods - ANSWER-- pre-op hair removal (clippers)
- wash hands
- normothermia
- maintain euglycemia
- urinary catheters are to be removed within the first two postoperative days
Osteoarthritis: what, incidence - ANSWER-Slow destruction of bones/ joint followed by production of
replacement collagen which causes inflammatory changes
- older than 60
- more female after 55
- more black than white women
- men and women equal risk between 45 - 55
- abnormal height or weight (obesity)
- repetitive movement
- prior trauma (sprains/ dislocations)
- diabetic neuropathy
- genetic
Osteoarthritis findings and diagnostics - ANSWER-- Pain in weight bearing joints
- stiffness after sitting, gets better when arising
- feeling of instability on stairs
- fine motor skills deficit
- larger affected joints
- Heberden nodules (bony bumps on the finger joint closest to the fingernail)
- Bouchard's nodules (bony bumps on the middle joint of the finger)
- limited ROM with crepitus
- xr shows narrowing of joint space (need anteroposterior and lateral knee films bilaterally)
- synovial fluid is clear and without WBC
Osteoarthritis treatment - ANSWER-Goal is to relieve symptoms, maintain/ improve function, and
avoid drug toxicity
Hand OA:
- rest/ joint protection, with splinting
- heat/ cold therapy
- topical capsaicin
,- topical NSAID (trolamine salicylate) (especially for older than 75)
- Oral NSAIDS, incl COX2 inhibitors such as celecoxib (Celebrex) (may cause cardiac problems)
- tramadol
- no opioids
Hip/ knee OA:
- weight reduction, cardiovascular exercises
- transcutanous external nerve stimulator
- acetaminophen
- Topical NSAIDS (knee)
- intraarticular corticosteroid injections
- surgery (joint replacement)
Rheumatoid arthritis: what, who - ANSWER-chronic, systemic autoimmune disease that causes
inflammation of connective tissue, first that of jionts them other soft tissues (renal, cardiovascular,
pulm). TNF-alpha plays a big role
- more women than men
- unknown cause
- Epstein Barr virus
Rheumatoid arthritis: Findings and diagnostics - ANSWER-- symmetric joint/ muscle pain, worse in the
morning then gets better
- weakness, fatigue
- anorexia, weight loss
- generalized malaise
- swollen joints/ boggy feeling of joints with deformity of joints
- warm, red skin on affected joints
later:
- pleural effusions and pulmonary nodules
- inflammation of sclerea (scleritis)
- pericarditis, myocarditis
- splenomegaly (Felty's syndrome)
- anemia (hypochromic, microcytic) with low ferritin
- possibly: positive rheumatoid factor
- XR: joint swelling, later cortical and space thinning
- synovial fluid: yellow, thick with elevated WBC up to 100.000
Felty's syndrome - ANSWER-rheumatoid arthritis, splenomegaly, neutropenia
Rheumatoid arthritis treatment - ANSWER-- early treatment better than stepwise
- early referral rheumatologist
- disease-modifying anti-rheumatic drugs (DMARDs):
- methotrexate ( no alcohol, monitor renal and liver, give with folic acid)
- cyclosporine
- Gold preparations (can cause thrombocytopenia)
- Hydroxychloroquine: antimalarial drug (may cause visual changes, monitor)
- sulfasalazine, moderate RA
- Leflunomide, moderate to severe RA
- Etanercept
- monitor liver function with DMARDs
- screen for TB (skin test) and Hep B
- surgery: joint debridement, joint replacement
Gout: what, who - ANSWER-Inflammatory disorder in response to high uric acid production/ levels in
blood and synovial fluid causing crystallization which causes inflammation (Type A and Mediterranean)
, - impaired renal function which causes excess uric acid
- foods high in purine, such as dairy, red meat, shellfish, beer
Gout findings, diagnostics - ANSWER-- acute painful joint, often great toe (warm, swollen)
- pain at night
- flank pain because of renal calculi
- fever
- leukocytosis
- elevated erythrocyte sedimentation rate
- tophi (bump under skin) on ear
- limited joint motion
- elevated serum uric acid (greater than 7mg/dl)
- urate crystals seen with joint aspiration
- xr: joint erosion and renal stones
Gout treatment - ANSWER-- NSAIDS: naproxen, ondomethacin, sulindac
- Colchicine for those who do not tolerate NSAIDS (caution with renal impairment). Also for
prophylaxis
- Corticosteroids, if NSAIDS and colchicine not tolerated
- 24hr urine for uric acid
- Allopurinol after flare is over (100mg PO daily)
- Biological modifiers of disease (BMD): Pegloticase. Not for asymptomatic. Treat with prophylaxis first.
Monitor serum uric acid
ANA. Tests in rheumatic disease: what, normal level, abnormal with. - ANSWER-Antinuclear antibody
(ANA).
Normal: Titer 1.32
POsitive with: Sjogren's (SS), SLE (lupus),
C4 Complement. Tests in rheumatic disease: what, normal level, abnormal with. - ANSWER-
Determines hemolytic activity which speaks to level of inflammatory response
Normal: men: 12-72. Women: 13-75 mg/dl
Increased with: inflammatory disease
Decreased with: RA, lupus, SS
The radioallergosorbent test (RAST). Tests in rheumatic disease: what, normal level, abnormal with. -
ANSWER-measures presence/ increase antigen IgE
normal: 0.01 - 0.04 mg/dl
Increased with allergic reaction
Erythrocyte sedimentation rate (ESR). Tests in rheumatic disease: what, normal level, abnormal with. -
ANSWER-rate at which RBC settle out of unclotted blood in 1 hr
Normal: men: 0-7mm/hr, women: 0 - 25 mm/hr
Increased with inflammation
CRP. Tests in rheumatic disease: what, normal level, abnormal with. - ANSWER-C-reactive protein, a
non-specific antigen antibody
Normal: trace to 6mg/ml
Increased with infection and inflammation, RA. Decreased with succesfull RA treatment
RF. Tests in rheumatic disease: what, normal level, abnormal with. - ANSWER-Rheumatoid factor.
antibody against IgG.
Positive RF in most people with RA
Corticosteroids and arthritis: what does it do and adverse effects - ANSWER-Not for maintenance
