ADVANCED PATHOPHYSIOLOGY EDAPT HEMOGLOBINOPATHIES QUESTIONS WITH 100% CORRECT ANSWERS + RATIONALES 2025/2026 (QUESTIONS WITH 100% CORRECT ANSWERS + RATIONALES (A+ GRADED) Hemoglobinopathy - Correct Answer-- Hemoglobinopathy is a genetic disorder characterized by anomalies in the structure or synthesis of hemoglobin, the oxygen-carrying protein found in red blood cells - These disorders stem from mutations in the genes responsible for encoding the globin chains of hemoglobin - As a result, individuals may have altered hemoglobin function, stability, or production and a range of clinical manifestations - Sickle cell disease and beta-thalassemia are among the most prevalent hemoglobinopathies - Approximately 5% of the world's population are gene carriers for sickle cell disease or thalassemia Which of the following best describes the primary pathophysiological mechanism underlying sickle cell disease? 1. Dysregulated iron metabolism causing excessive iron deposition 2. Abnormal clotting leading to vascular occlusion 3. Impaired immune response leading to frequent infections 4. Altered synthesis of hemoglobin due to a mutation in the beta-globin gene - Correct Answer-4. Altered synthesis of hemoglobin due to a mutation in the beta-globin gene Rationale: CONTINUES...
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