UNE BIOCHEM 1005 FINAL EXAM 2025
QUESTIONS AND ANSWERS
Somatostatin reduces the secretion of both glucagon and insulin through which of the following
mechanisms?
a. Somatostatin activates an activator G-protein
b. Somatostatin activates MAPK cascade
c. Somatostatin activates an inhibitory G-protein
d. Somatostatin uses Ca+2 as a downstream signal - ANS c. Somatostatin activates an
inhibitory G-protein
Insulin mediated glucose uptake by muscle and adipose tissue is a result of which of the
following mechanisms?
a. Translocation of GLUT 4 receptors to the cell surface
b. Translocation of GLUT 1 (Na+/K+ symporter) to the cell surface
c. Passive diffusion
d. Activation of protein kinase A - ANS a. Translocation of GLUT 4 receptors to the cell
surface
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The alanine - glucose cycle is primarily used for which of the following purposes?
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, a. To move ammonia from skeletal muscle to the liver
b. To generate ATP for the skeletal muscle
c. To move glucose from the skeletal muscle to the liver
d. To move alanine from the liver to the skeletal muscle - ANS a. To move ammonia from
skeletal muscle to the liver
Which statement best illustrates an example of post translational gene regulation?
a. Protein kinase A mediated phosphorylation of glycogen phosphorylase
b. Cortisol binds a cytosolic receptor, translocates to the nucleus and binds a GRE
c. Iron binding the iron response elements binding protein (IRE_BP) allowing for translation of
ferritin mRNA
d. DNA histone associations leading to super-coiling of DNA - ANS a. Protein kinase A
mediated phosphorylation of glycogen phosphorylase
Which of the following hormones is released from the liver in response to increased levels of
growth hormone?
a. Cortisol
b. Thyroid hormone
c. Somatostatin
d. Insulin-like growth factor (IGF) - ANS d. Insulin-like growth factor (IGF)
Autophagy is process involves degradation of protein. Under conditions of high energy (HIGH
ATP) which of the following is true regarding regulation of this process?
a. Akt is inactive
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b. AMPK is actice and phosphorylates TSC1/TSC2 Complex
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, c. mTOR is activated
d. Rheb is bound to GDP - ANS c. mTOR is activated
Synthesis of which of the following lipoproteins would be elevated after a carbohydrate rich
meal?
a. HDL
b. Chylomicrons
c. LDL
d. VLDL - ANS d. VLDL
The synthesis of N-acetylglutamate (NAGS) is required for the activity of the urea cycle. This
compound stimulates the activity of which of the following enzymes?
a. Arginase
b. Carbamoyl phosphate synthetase I (CPSI)
c. Ornithine transcarbamoylase
d. Carbamoyl phosphate synthetase II (CPSII) - ANS b. Carbamoyl phosphate synthetase I
(CPSI)
A male infant starts to show signs of lethargy rapidly after birth. Upon evaluation he is
determined to have a deficiency in n-acetylglutamate synthesis. Based on this information,
which of the following would consistent with this diagnosis?
a. Elevated levels of arginine
b. Decreased levels of carbamoyl phosphate
c. Decreased levels of ammonia
d. Elevated levels of citrulline - ANS b. Decreased levels of carbamoyl phosphate
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QUESTIONS AND ANSWERS
Somatostatin reduces the secretion of both glucagon and insulin through which of the following
mechanisms?
a. Somatostatin activates an activator G-protein
b. Somatostatin activates MAPK cascade
c. Somatostatin activates an inhibitory G-protein
d. Somatostatin uses Ca+2 as a downstream signal - ANS c. Somatostatin activates an
inhibitory G-protein
Insulin mediated glucose uptake by muscle and adipose tissue is a result of which of the
following mechanisms?
a. Translocation of GLUT 4 receptors to the cell surface
b. Translocation of GLUT 1 (Na+/K+ symporter) to the cell surface
c. Passive diffusion
d. Activation of protein kinase A - ANS a. Translocation of GLUT 4 receptors to the cell
surface
1
The alanine - glucose cycle is primarily used for which of the following purposes?
Page
@COPYRIGHT @THEBRIGHT 2025/2026
, a. To move ammonia from skeletal muscle to the liver
b. To generate ATP for the skeletal muscle
c. To move glucose from the skeletal muscle to the liver
d. To move alanine from the liver to the skeletal muscle - ANS a. To move ammonia from
skeletal muscle to the liver
Which statement best illustrates an example of post translational gene regulation?
a. Protein kinase A mediated phosphorylation of glycogen phosphorylase
b. Cortisol binds a cytosolic receptor, translocates to the nucleus and binds a GRE
c. Iron binding the iron response elements binding protein (IRE_BP) allowing for translation of
ferritin mRNA
d. DNA histone associations leading to super-coiling of DNA - ANS a. Protein kinase A
mediated phosphorylation of glycogen phosphorylase
Which of the following hormones is released from the liver in response to increased levels of
growth hormone?
a. Cortisol
b. Thyroid hormone
c. Somatostatin
d. Insulin-like growth factor (IGF) - ANS d. Insulin-like growth factor (IGF)
Autophagy is process involves degradation of protein. Under conditions of high energy (HIGH
ATP) which of the following is true regarding regulation of this process?
a. Akt is inactive
2
Page
b. AMPK is actice and phosphorylates TSC1/TSC2 Complex
@COPYRIGHT @THEBRIGHT 2025/2026
, c. mTOR is activated
d. Rheb is bound to GDP - ANS c. mTOR is activated
Synthesis of which of the following lipoproteins would be elevated after a carbohydrate rich
meal?
a. HDL
b. Chylomicrons
c. LDL
d. VLDL - ANS d. VLDL
The synthesis of N-acetylglutamate (NAGS) is required for the activity of the urea cycle. This
compound stimulates the activity of which of the following enzymes?
a. Arginase
b. Carbamoyl phosphate synthetase I (CPSI)
c. Ornithine transcarbamoylase
d. Carbamoyl phosphate synthetase II (CPSII) - ANS b. Carbamoyl phosphate synthetase I
(CPSI)
A male infant starts to show signs of lethargy rapidly after birth. Upon evaluation he is
determined to have a deficiency in n-acetylglutamate synthesis. Based on this information,
which of the following would consistent with this diagnosis?
a. Elevated levels of arginine
b. Decreased levels of carbamoyl phosphate
c. Decreased levels of ammonia
d. Elevated levels of citrulline - ANS b. Decreased levels of carbamoyl phosphate
3
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