ASCP BOC EXAM Study Guide Exam
2026 Questions and Answers 100% Pass
Guaranteed
When using an electronic cell counter, which of the following results can occur in
the presence of a cold agglutination? a) increased MCV and decreased RBC b)
increased MCV and normal RBC c) decreased MCV and increased MCHC d)
decreased MCV and RBC - Correct answer-a) increased MCV and decreased RBC
Cerebrospinal fluid for glucose assay should be: a) refrigerated b) analyzed
immediately c) heated to 56 degree C d) stored at room temp after centrifugation -
Correct answer-b) analyzed immediately
The major crossmatch will detect: a) group A patient mistyped as group O b)
unexpected red cell antibody in the donor unit c) Rh-neg donor unit mislabeled as
Rh-Pos d) recipient antibody directly against antigens on the donor red cells -
Correct answer-d) recipient antibody directly against antigens on the donor red
cells
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,The anion gap is useful for quality control of laboratory reselts for a) amino acids
and proteins b) blood gas anaylses c) sodium, potassium, chloride and total C02 d)
calcium, phosphorus and magnesium - Correct answer-c) sodium, potassium,
chloride and total C02
A common cause of respiratory alkalosis is a) vomitting b) starvation c) asthma d)
hyperventilation - Correct answer-d) hyperventilation
Blood is diluted 1:200, and a platelet count is performed. 180 platelets were
counted in the center square millimeter on one side of the hemacytometer and 186
on the other side/ The total platelet count is: a) 146 x 10³/μL (146 x 10⁹/L) b)183 x
10³/μL (183 x 10⁹/L) c)366 x 10³/μL (3666 x 10⁹/L) d)732 x 10³/μL (732 x 10⁹/L) -
Correct answer-c)366 x 10³/μL (3666 x 10⁹/L)
When staining acid-fast bacilli with Truant auramine-rhodamine stain, potassium
permanganate is used a a) decolorizing agent b) quenching agent c) mordant d) dye
- Correct answer-b) quenching agent
A first morning sputum is received for culture of acid-fast bacilli. It is digested and
concentrated by the N-acetyl-L-cysteine alkali method. Two Sabouraud dextrose
slants are incubated in the dark at 35ºC with 5%-10% CO2. The smear reveal acid-
fast bacilli, but the slants show no growth after 8 weeks. The explanation is: a)
improper media used b) incorrect concentration procedure used c) improper
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, specimen submitted d) exposure to CO2 prevents growth - Correct answer-a)
improper media used
MacConkey media for screening suspected cases of hemorrhagic E. coli O157:H7
must contain: a) indole b) citrate c) sorbitol d) lactose - Correct answer-c) sorbitol
A patient with a B-cell deficiency will most likely exhibit: a) decreased
phagocytosis b) increased bacterial infections c) decreased complement levels d)
increased complement levels - Correct answer-b) increased bacterial infections
Communication is enhanced by: a) a planned strategy that includes listening skills
and ensuring an understanding with questions b) relying on e-mail, memos and
voice mail to communicate new information c) formal, hierachical patterns instead
of informal networking patterns d) assumptions if there are questions about the
intent of the message - Correct answer-a) a planned strategy that includes listening
skills and ensuring an understanding with questions
IgM antibodies are frequently hemolytic because of: a)the dimeric structure b) the
molecule's 5 antigen binding sites c) their sedimentation coefficient of 7-15 S d)
their coefficient ability to fix complement - Correct answer-b) the molecule's 5
antigen binding sites
A community hospital microbiology laboratory is processing significant numbers
of stool cultures because of an outbreak of diarrhea following heavy rains and
©COPYRIGHT 2025, ALL RIGHTS RESERVE 3
2026 Questions and Answers 100% Pass
Guaranteed
When using an electronic cell counter, which of the following results can occur in
the presence of a cold agglutination? a) increased MCV and decreased RBC b)
increased MCV and normal RBC c) decreased MCV and increased MCHC d)
decreased MCV and RBC - Correct answer-a) increased MCV and decreased RBC
Cerebrospinal fluid for glucose assay should be: a) refrigerated b) analyzed
immediately c) heated to 56 degree C d) stored at room temp after centrifugation -
Correct answer-b) analyzed immediately
The major crossmatch will detect: a) group A patient mistyped as group O b)
unexpected red cell antibody in the donor unit c) Rh-neg donor unit mislabeled as
Rh-Pos d) recipient antibody directly against antigens on the donor red cells -
Correct answer-d) recipient antibody directly against antigens on the donor red
cells
©COPYRIGHT 2025, ALL RIGHTS RESERVE 1
,The anion gap is useful for quality control of laboratory reselts for a) amino acids
and proteins b) blood gas anaylses c) sodium, potassium, chloride and total C02 d)
calcium, phosphorus and magnesium - Correct answer-c) sodium, potassium,
chloride and total C02
A common cause of respiratory alkalosis is a) vomitting b) starvation c) asthma d)
hyperventilation - Correct answer-d) hyperventilation
Blood is diluted 1:200, and a platelet count is performed. 180 platelets were
counted in the center square millimeter on one side of the hemacytometer and 186
on the other side/ The total platelet count is: a) 146 x 10³/μL (146 x 10⁹/L) b)183 x
10³/μL (183 x 10⁹/L) c)366 x 10³/μL (3666 x 10⁹/L) d)732 x 10³/μL (732 x 10⁹/L) -
Correct answer-c)366 x 10³/μL (3666 x 10⁹/L)
When staining acid-fast bacilli with Truant auramine-rhodamine stain, potassium
permanganate is used a a) decolorizing agent b) quenching agent c) mordant d) dye
- Correct answer-b) quenching agent
A first morning sputum is received for culture of acid-fast bacilli. It is digested and
concentrated by the N-acetyl-L-cysteine alkali method. Two Sabouraud dextrose
slants are incubated in the dark at 35ºC with 5%-10% CO2. The smear reveal acid-
fast bacilli, but the slants show no growth after 8 weeks. The explanation is: a)
improper media used b) incorrect concentration procedure used c) improper
©COPYRIGHT 2025, ALL RIGHTS RESERVE 2
, specimen submitted d) exposure to CO2 prevents growth - Correct answer-a)
improper media used
MacConkey media for screening suspected cases of hemorrhagic E. coli O157:H7
must contain: a) indole b) citrate c) sorbitol d) lactose - Correct answer-c) sorbitol
A patient with a B-cell deficiency will most likely exhibit: a) decreased
phagocytosis b) increased bacterial infections c) decreased complement levels d)
increased complement levels - Correct answer-b) increased bacterial infections
Communication is enhanced by: a) a planned strategy that includes listening skills
and ensuring an understanding with questions b) relying on e-mail, memos and
voice mail to communicate new information c) formal, hierachical patterns instead
of informal networking patterns d) assumptions if there are questions about the
intent of the message - Correct answer-a) a planned strategy that includes listening
skills and ensuring an understanding with questions
IgM antibodies are frequently hemolytic because of: a)the dimeric structure b) the
molecule's 5 antigen binding sites c) their sedimentation coefficient of 7-15 S d)
their coefficient ability to fix complement - Correct answer-b) the molecule's 5
antigen binding sites
A community hospital microbiology laboratory is processing significant numbers
of stool cultures because of an outbreak of diarrhea following heavy rains and
©COPYRIGHT 2025, ALL RIGHTS RESERVE 3
