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PSI Exam Psychopharmacology Study Guide 2025/2026 – Complete Manual Review & Practice

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PSI Exam Psychopharmacology Study Guide 2025/2026 – Complete Manual Review & Practice

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PSI Exam
Psychopharmacology
Study Guide
1. Which of the following best describes psychopharmacology?
A. The study of the brain's structure
B. The study of how drugs affect mood, behavior, and thinking
C. The process of counseling patients
D. The study of genetics and behavior


Answer: B. The study of how drugs affect mood, behavior, and thinking


2. Which term refers to the movement of drugs within the body, including
absorption, distribution, metabolism, and excretion?
A. Pharmacodynamics
B. Pharmacokinetics
C. Homeostasis
D. Biotransformation


Answer: B. Pharmacokinetics


3. What is the primary function of neurotransmitters?
A. To store energy in neurons
B. To transmit signals across synapses
C. To create hormones
D. To maintain blood pressure

,Answer: B. To transmit signals across synapses


4. The blood-brain barrier functions to:
A. Allow all substances to enter the brain freely
B. Protect the brain by limiting the passage of certain drugs and chemicals
C. Increase the speed of drug absorption into the brain
D. Store neurotransmitters


Answer: B. Protect the brain by limiting the passage of certain drugs and chemicals


Section 2: Antidepressants


5. Which class of antidepressants is most associated with serotonin syndrome?
A. Tricyclic antidepressants (TCAs)
B. Monoamine oxidase inhibitors (MAOIs)
C. Selective serotonin reuptake inhibitors (SSRIs)
D. Benzodiazepines


Answer: C. Selective serotonin reuptake inhibitors (SSRIs)


6. Which of the following symptoms is not commonly associated with serotonin
syndrome?
A. Sweating
B. Hyperreflexia
C. Hallucinations
D. Bradycardia


Answer: D. Bradycardia


7. Which neurotransmitter is primarily targeted by SSRIs?
A. Dopamine

, B. Norepinephrine
C. Serotonin
D. GABA


Answer: C. Serotonin


8. Which antidepressant class requires dietary restrictions due to tyramine
interaction?
A. SSRIs
B. SNRIs
C. MAOIs
D. TCAs


Answer: C. MAOIs


Section 3: Antipsychotics


9. What is a common side effect of typical (first-generation) antipsychotics?
A. Insomnia
B. Extrapyramidal symptoms (EPS)
C. Weight loss
D. Hypertension


Answer: B. Extrapyramidal symptoms (EPS)


10. Clozapine, an atypical antipsychotic, requires regular monitoring of:
A. Blood sugar
B. Heart rate
C. White blood cell count (WBC)
D. Liver enzymes


Answer: C. White blood cell count (WBC)

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