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ONS ONCC Chemo Renewal 2025 COMPREHENSIVE EXAM
QUESTIONS WITH DETAILED VERIFIED AND 100% CORRECT
ANSWERS BRAND NEW EXAM ALREADY GRADED A+!!
_____________can cause blistering and significant pain and tissue
damage and destruction, leading to tissue death. - . . ANSWER
✓✓ Vesicants
_____________can cause inflammation, pain, and burning but rarely
cause tissue necrosis comparable to a vesicant (unless a large
amount or a very high concentration of the irritant is
extravasated). - . . ANSWER ✓✓ Irrirtants
A further classification of an antineoplastic agent's potential to
cause damage is whether its mechanism of action includes DNA
binding. - . . ANSWER ✓✓ Non-DNA-binding solutions remain in
the local area of the extravasation, which improves the
possibility of drug deactivation.
DNA-binding agents attach to DNA nucleic acids, causing the
antagonist to be ingested cellularly, leading to progressive tissue
destruction
Amgen (2007) defines RDI as "is a quantification of how closely
an administered course of chemotherapy treatment adheres to a
specific regimen." Three separate clinical trials evaluating
outcomes in patients with breast cancer related to RDI have
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demonstrated improved overall survival and 10-year disease free
survival in patients who receive a RDI > or = ____?_____ - . .
ANSWER ✓✓ 85%
ANC Calculation - . . ANSWER ✓✓ ANC = (Neutrophils + Bands) x
WBC / 100
To calculate the ANC:
Find the WBC, the polys/neutrophils and bands on your CBC
(neutrophils can be called many things in a differential including:
polymorphonuclear cells or polys, PMNs, granulocytes,
segmented neutrophils, or segs). WBC = 2.1
Add the polys and bands (polys = 22%, bands = 4%). 22 + 4 = 26
Multiply the sum of the polys and bands by the WBC. 26 X 2.1 =
54.6
Multiply the product by 10. 54.6 X 10 = 546
Mrs. Turner's ANC is 546
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Cold sensory neuropathy symptoms - . . ANSWER ✓✓ Transient
paresthesia
Dysesthesia and hypoesthesia in the hands, feet, perioral area,
or throat.
Jaw spasm
Abnormal tongue sensation
Dysarthria
Eye pain, and a feeling of chest pressure have also been
observed
DNA Binding Irritants - . . ANSWER ✓✓ Bendamustinea
Dactinomycin
Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
Mechlorethamine
Mitomycin
DNA Nonbinding vessicants - . . ANSWER ✓✓ Amsacrine
Paclitaxel
Vinblastine
Vincristine
ONS ONCC Chemo Renewal 2025 COMPREHENSIVE EXAM
QUESTIONS WITH DETAILED VERIFIED AND 100% CORRECT
ANSWERS BRAND NEW EXAM ALREADY GRADED A+!!
_____________can cause blistering and significant pain and tissue
damage and destruction, leading to tissue death. - . . ANSWER
✓✓ Vesicants
_____________can cause inflammation, pain, and burning but rarely
cause tissue necrosis comparable to a vesicant (unless a large
amount or a very high concentration of the irritant is
extravasated). - . . ANSWER ✓✓ Irrirtants
A further classification of an antineoplastic agent's potential to
cause damage is whether its mechanism of action includes DNA
binding. - . . ANSWER ✓✓ Non-DNA-binding solutions remain in
the local area of the extravasation, which improves the
possibility of drug deactivation.
DNA-binding agents attach to DNA nucleic acids, causing the
antagonist to be ingested cellularly, leading to progressive tissue
destruction
Amgen (2007) defines RDI as "is a quantification of how closely
an administered course of chemotherapy treatment adheres to a
specific regimen." Three separate clinical trials evaluating
outcomes in patients with breast cancer related to RDI have
,2|Page
demonstrated improved overall survival and 10-year disease free
survival in patients who receive a RDI > or = ____?_____ - . .
ANSWER ✓✓ 85%
ANC Calculation - . . ANSWER ✓✓ ANC = (Neutrophils + Bands) x
WBC / 100
To calculate the ANC:
Find the WBC, the polys/neutrophils and bands on your CBC
(neutrophils can be called many things in a differential including:
polymorphonuclear cells or polys, PMNs, granulocytes,
segmented neutrophils, or segs). WBC = 2.1
Add the polys and bands (polys = 22%, bands = 4%). 22 + 4 = 26
Multiply the sum of the polys and bands by the WBC. 26 X 2.1 =
54.6
Multiply the product by 10. 54.6 X 10 = 546
Mrs. Turner's ANC is 546
, 3|Page
Cold sensory neuropathy symptoms - . . ANSWER ✓✓ Transient
paresthesia
Dysesthesia and hypoesthesia in the hands, feet, perioral area,
or throat.
Jaw spasm
Abnormal tongue sensation
Dysarthria
Eye pain, and a feeling of chest pressure have also been
observed
DNA Binding Irritants - . . ANSWER ✓✓ Bendamustinea
Dactinomycin
Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
Mechlorethamine
Mitomycin
DNA Nonbinding vessicants - . . ANSWER ✓✓ Amsacrine
Paclitaxel
Vinblastine
Vincristine
