Medicinal Chemistry Exam 1 Questions and All Correct Answers.

pharmacophore - Answer the pattern of features of a molecule that is responsible for a biological effect, involved in drug-receptor interactions ideal drug has... - Answer - has a desired effect - few side effects - reaches intended site of action with correct concentration - remains at the site of action for correct amt. of time - can be removed when done interacts with a part of the body to... - Answer enhance or decrease an existing physiological or biochemical process- can't make body do something its not designed to do drug - Answer chemical that interacts with the living org. producing an effect which can be used to treat, diagnose, prevent a medical problem or modify a *physiological function* therapeutic index - Answer measure of a drug's beneficial effect at a low dose vs. harmful effects at a high does; high index = large safety margin b/w good and toxic dose selective toxicity - Answer many chemicals are considered effective because they are toxic only to 'problem' cells' and not normal cells classification of drug molecules - Answer pharmacological effect chemical structure target system target molecule endogenous drug - Answer drugs may be synthesized within the body medicinal chemistry - Answer science that deals with the discovery and design of therapeutic chemicals and thier development into useful medicines - the isolation of natural products