TEST BANKb
Cellular and Molecular Immunology
b b b
Abul Abbas, Andrew Lichtman, and Shiv Pillai
b b b b b b
10thEdition
b
,Table of Contents
b b
Chapter 01 Properties and Overview of Immune Responses
b b b b b b b 1
Chapter 02 Cells and Tissues of the Immune System
b b b b b b b b 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
b b b b b b b 6
Chapter 04 Innate Immunity
b b b 10
Chapter 05 Antibodies and Antigens
b b b b 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
b b b b b b b b b b b
Histocompatibility Complex Molecules b b 20
Chapter 07 Immune Receptors and Signal Transduction
b b b b b b 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
b b b b b b b b 30
Chapter 09 Activation of T Lymphocytes
b b b b b 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
b b b b b b b b b 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
b b b b b b b b b 42
Chapter 12 B Cell Activation and Antibody Production
b b b b b b b 46
Chapter 13 Effector Mechanisms of Humoral Immunity
b b b b b b 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
b b b b b b b b b b b 56
Chapter 15 Immunologic Tolerance and Autoimmunity
b b b b b 62
Chapter 16 Immunity to Microbes
b b b b 67
Chapter 17 Transplantation Immunology
b b b 72
Chapter 18 Tumor Immunology
b b b 77
Chapter 19 Hypersensitivity Disorders
b b b 81
Chapter 20 Allergy
b b 86
Chapter 21 Primary and Acquired Immunodeficiencies
b b b b b 89
,Chapter 01: Properties and Overview of Immune Responses
b b b b b b b
Abbas, Lichtman, and Pillai:Cellular and Molecular Immunology, 10thEdition
b b b b b b b b b
MULTIPLECHOICE b
1. The principal function of the immune system is:
b b b b b b b
a. Defenseagainst cancer b b
b. Repair of injured tissues b b b
c. Defenseagainst microbial infections b b b
d. Prevention of inflammatorydiseases b b b
e. Protection against environmental toxins b b b
ANS: C b
The immune system has evolved in the setting of selective pressures imposed by microbial
b b b b b b b b b b b b b
infections. Although immune responses to cancer may occur, the concept that
b b b b b b b b b b b
“immunosurveillance” against cancer is a principal function of the immune system is
b b b b b b b b b b b b
controversial. Repair of injured tissues may be a secondary consequence of the immune
b b b b b b b b b b b b b
responses and inflammation. Although the immune system has regulatory features that are
b b b b b b b b b b b b
needed to prevent excessive inflammation, prevention of inflammatory diseases is not a
b b b b b b b b b b b b
primary function. The immune system can protect against microbial toxins, but it generally does
b b b b b b b b b b b b b b
not offer protection against toxins of nonbiologic origin.
b b b b b b b b
2. Which of the following infectious diseases was prevented by the first successful
b b b b b b b b b b b
vaccination?
b
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C b
In 1798, Edward Jenner reported the first intentional successful vaccination, which was against
b b b b b b b b b b b b
smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, smallpox
b b b b b b b b b b b b b b b b
was reported to be eradicated worldwide by a vaccination program. Effective vaccines against
b b b b b b b b b b b b b
tetanus toxin, rubella virus, and poliovirus were developed in the 20th century and are widely
b b b b b b b b b b b b b b b
used. There is no effective vaccine against Mycobacterium tuberculosis.
b b b b b b b b b
3. Which of the following is a unique property of the adaptive immune system?
b b b b b b b b b b b b
a. Highly diverse repertoire of specificities for antigens b b b b b b
b. Self-nonself discrimination b
c. Recognition of microbial structures by both cell-associated and soluble receptors b b b b b b b b b
d. Protection against viral infections b b b
e. Responses that have the same kinetics and magnitude on repeated exposure to the b b b b b b b b b b b b
same microbe b b
ANS: A b
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphocytes,
b b b b b b b b b b b b b b
which are the central cellular components of the adaptive immune system. Both the innate and
b b b b b b b b b b b b b b b
the adaptive immune systems use cell-associated and soluble receptors to recognize microbes,
b b b b b b b b b b b b
display some degree of self-nonself discrimination, and protect against viruses. On repeated
b b b b b b b b b b b b
exposure to the same microbe, the adaptive immune response becomes more rapid and of
b b b b b b b b b b b b b b
greater magnitude; this is the manifestation of memory.
b b b b b b b b
4. Antibodies and T lymphocytes are the respective mediators of which two types of b b b b b b b b b b b b
immunity?
b
a. Innate and adaptive b b
b. Passive and active b b
c. Specific and nonspecific b b
d. Humoral and cell-mediated b b
e. Adult and neonatal b b
ANS: D b
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes
b b b b b b b b b b b b
produce antibodies, which are the recognition and effector molecules of humoral immune
b b b b b b b b b b b b
responses to extracellular pathogens. T cells recognize and promote eradication of intracellular
b b b b b b b b b b b b
pathogens in cell-mediated immunity. Passive and active immunity both can be mediated by
b b b b b b b b b b b b b
either B or T lymphocytes. Specific immunity is another term for adaptive immunity. Both B and
b b b b b b b b b b b b b b b b
T lymphocytes participate in adult adaptive immunity but are still developing in the neonatal
b b b b b b b b b b b b b b
period.
b
5. The two major functional classes of effector T lymphocytes are:
b b b b b b b b b
a. Helper T lymphocytes and cytotoxic T lymphocytes b b b b b b
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes b b b b
c. Memory T cells and effector T cells b b b b b b
d. Helpercells and antigen-presenting cells b b b b
e. Cytotoxic T lymphocytes and target cells b b b b b
ANS: A b
T cells can be classified into effector subsets that perform different effector functions. Most
b b b b b b b b b b b b b
effector T cells are either helper T lymphocytes, which enhance the responses of other immune
b b b b b b b b b b b b b b b
cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, which
b b b b b b b b b b b b b
directly kill infected cells. Natural killer cells are not T lymphocytes.
b b b b b b b b b b b
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. b b b b b b b b b b b b b b
6. Which of the following cell types is required for all adaptive humoral immune responses?
b b b b b b b b b b b b b
a. Natural killer cells b b
b. Dendritic cells b
c. Cytolytic T lymphocytes b b
d. B lymphocytes b
e. Helper T lymphocytes b b
ANS: D b
Humoral immune responses are antibody-mediated immune responses, and all antibodies are
b b b b b b b b b b
made by B lymphocytes and no other cell type.
b b b b b b b b b
Cellular and Molecular Immunology
b b b
Abul Abbas, Andrew Lichtman, and Shiv Pillai
b b b b b b
10thEdition
b
,Table of Contents
b b
Chapter 01 Properties and Overview of Immune Responses
b b b b b b b 1
Chapter 02 Cells and Tissues of the Immune System
b b b b b b b b 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
b b b b b b b 6
Chapter 04 Innate Immunity
b b b 10
Chapter 05 Antibodies and Antigens
b b b b 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
b b b b b b b b b b b
Histocompatibility Complex Molecules b b 20
Chapter 07 Immune Receptors and Signal Transduction
b b b b b b 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
b b b b b b b b 30
Chapter 09 Activation of T Lymphocytes
b b b b b 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
b b b b b b b b b 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
b b b b b b b b b 42
Chapter 12 B Cell Activation and Antibody Production
b b b b b b b 46
Chapter 13 Effector Mechanisms of Humoral Immunity
b b b b b b 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
b b b b b b b b b b b 56
Chapter 15 Immunologic Tolerance and Autoimmunity
b b b b b 62
Chapter 16 Immunity to Microbes
b b b b 67
Chapter 17 Transplantation Immunology
b b b 72
Chapter 18 Tumor Immunology
b b b 77
Chapter 19 Hypersensitivity Disorders
b b b 81
Chapter 20 Allergy
b b 86
Chapter 21 Primary and Acquired Immunodeficiencies
b b b b b 89
,Chapter 01: Properties and Overview of Immune Responses
b b b b b b b
Abbas, Lichtman, and Pillai:Cellular and Molecular Immunology, 10thEdition
b b b b b b b b b
MULTIPLECHOICE b
1. The principal function of the immune system is:
b b b b b b b
a. Defenseagainst cancer b b
b. Repair of injured tissues b b b
c. Defenseagainst microbial infections b b b
d. Prevention of inflammatorydiseases b b b
e. Protection against environmental toxins b b b
ANS: C b
The immune system has evolved in the setting of selective pressures imposed by microbial
b b b b b b b b b b b b b
infections. Although immune responses to cancer may occur, the concept that
b b b b b b b b b b b
“immunosurveillance” against cancer is a principal function of the immune system is
b b b b b b b b b b b b
controversial. Repair of injured tissues may be a secondary consequence of the immune
b b b b b b b b b b b b b
responses and inflammation. Although the immune system has regulatory features that are
b b b b b b b b b b b b
needed to prevent excessive inflammation, prevention of inflammatory diseases is not a
b b b b b b b b b b b b
primary function. The immune system can protect against microbial toxins, but it generally does
b b b b b b b b b b b b b b
not offer protection against toxins of nonbiologic origin.
b b b b b b b b
2. Which of the following infectious diseases was prevented by the first successful
b b b b b b b b b b b
vaccination?
b
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C b
In 1798, Edward Jenner reported the first intentional successful vaccination, which was against
b b b b b b b b b b b b
smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, smallpox
b b b b b b b b b b b b b b b b
was reported to be eradicated worldwide by a vaccination program. Effective vaccines against
b b b b b b b b b b b b b
tetanus toxin, rubella virus, and poliovirus were developed in the 20th century and are widely
b b b b b b b b b b b b b b b
used. There is no effective vaccine against Mycobacterium tuberculosis.
b b b b b b b b b
3. Which of the following is a unique property of the adaptive immune system?
b b b b b b b b b b b b
a. Highly diverse repertoire of specificities for antigens b b b b b b
b. Self-nonself discrimination b
c. Recognition of microbial structures by both cell-associated and soluble receptors b b b b b b b b b
d. Protection against viral infections b b b
e. Responses that have the same kinetics and magnitude on repeated exposure to the b b b b b b b b b b b b
same microbe b b
ANS: A b
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphocytes,
b b b b b b b b b b b b b b
which are the central cellular components of the adaptive immune system. Both the innate and
b b b b b b b b b b b b b b b
the adaptive immune systems use cell-associated and soluble receptors to recognize microbes,
b b b b b b b b b b b b
display some degree of self-nonself discrimination, and protect against viruses. On repeated
b b b b b b b b b b b b
exposure to the same microbe, the adaptive immune response becomes more rapid and of
b b b b b b b b b b b b b b
greater magnitude; this is the manifestation of memory.
b b b b b b b b
4. Antibodies and T lymphocytes are the respective mediators of which two types of b b b b b b b b b b b b
immunity?
b
a. Innate and adaptive b b
b. Passive and active b b
c. Specific and nonspecific b b
d. Humoral and cell-mediated b b
e. Adult and neonatal b b
ANS: D b
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes
b b b b b b b b b b b b
produce antibodies, which are the recognition and effector molecules of humoral immune
b b b b b b b b b b b b
responses to extracellular pathogens. T cells recognize and promote eradication of intracellular
b b b b b b b b b b b b
pathogens in cell-mediated immunity. Passive and active immunity both can be mediated by
b b b b b b b b b b b b b
either B or T lymphocytes. Specific immunity is another term for adaptive immunity. Both B and
b b b b b b b b b b b b b b b b
T lymphocytes participate in adult adaptive immunity but are still developing in the neonatal
b b b b b b b b b b b b b b
period.
b
5. The two major functional classes of effector T lymphocytes are:
b b b b b b b b b
a. Helper T lymphocytes and cytotoxic T lymphocytes b b b b b b
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes b b b b
c. Memory T cells and effector T cells b b b b b b
d. Helpercells and antigen-presenting cells b b b b
e. Cytotoxic T lymphocytes and target cells b b b b b
ANS: A b
T cells can be classified into effector subsets that perform different effector functions. Most
b b b b b b b b b b b b b
effector T cells are either helper T lymphocytes, which enhance the responses of other immune
b b b b b b b b b b b b b b b
cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, which
b b b b b b b b b b b b b
directly kill infected cells. Natural killer cells are not T lymphocytes.
b b b b b b b b b b b
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. b b b b b b b b b b b b b b
6. Which of the following cell types is required for all adaptive humoral immune responses?
b b b b b b b b b b b b b
a. Natural killer cells b b
b. Dendritic cells b
c. Cytolytic T lymphocytes b b
d. B lymphocytes b
e. Helper T lymphocytes b b
ANS: D b
Humoral immune responses are antibody-mediated immune responses, and all antibodies are
b b b b b b b b b b
made by B lymphocytes and no other cell type.
b b b b b b b b b
